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Tytuł artykułu

MicroRNAs: emerging regulators for development of pancreatic islet lineages

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
MicroRNAs belong to a family of small (-23 nt) non-coding RNAs that mediate posttranscriptional gene silencing. They are emerging as important new regulators of differentiation and development. Knowledge of their role in pancreas and islet development, may help in developing a regenerative therapy for diabetes mellitus, a metabolic disorder affecting hundreds of millions of people worldwide. In this minireview, we summarize the latest evidence of the role these new regulators play in islet lineage development, aiming to attract more research into this important developmental regulators.
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Wydawca

Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
wydano
2014-07-01
otrzymano
2012-11-05
zaakceptowano
2012-11-28
online
2014-07-26
Twórcy
  • Centre for Diabetes Research, Western Australian Institute for Medical Research, and Centre for Medical Research, The University of Western Australia, Perth 6000, Australia
  • Centre for Diabetes Research, Western Australian Institute for Medical Research, and Centre for Medical Research, The University of Western Australia, Perth 6000, Australia
Bibliografia
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  • [10] Dumortier O, Van Obberghen E (2012) MicroRNAs in pancreas development. Diabetes Obes Metab 14 Suppl 3: 22-28.[WoS][Crossref][PubMed]
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  • [40] Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, et al. (2009) The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells. Islets 1: 137-147.[WoS]
  • [41] Tang X, Muniappan L, Tang G, Ozcan S (2009) Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA 15: 287-293.[Crossref][WoS]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_micrnado-2013-0002
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