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Tytuł artykułu

Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the effciency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages of the proposed method over the passive loading, especially when the difference between the dimensions of loaded materials and the pore diameter is small, an increase of up to 20-fold can be observed. The technique described in this study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical applications.
Słowa kluczowe
Wydawca

Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
online
2014-05-29
Twórcy
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
  • Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
autor
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
autor
  • Houston Methodist Research Institute, Department of Nanomedicine, 6670 Bertner Ave, R7-122, Houston, TX 77030. Tel: 713-441-7329, Fax: 713-441-7438, Email:
    bgodin@houstonmethodist.org
Bibliografia
  • [1] Anglin, E.J., Cheng, L., Freeman, W.R., Sailor, M.J., 2008,Porous silicon in drug delivery devices and materials, AdvancedDrug Delivery Reviews 60, 1266-1277.[WoS][Crossref]
  • [2] Arcos, D., López-Noriega, A., Ruiz-Hernández, E., Terasaki, O.,Vallet-Regí, M., 2009, Ordered mesoporous microspheres forbone grafting and drug delivery, Chemistry of Materials 21,1000-1009.[Crossref]
  • [3] Bimbo, L.M., Sarparanta, M., Santos, H.A., Airaksinen, A.J.,Mäkilä, E., Laaksonen, T., et al., 2010, Biocompatibility ofthermally hydrocarbonized porous silicon nanoparticles andtheir biodistribution in rats, ACS Nano 4, 3023-3032.[WoS][Crossref]
  • [4] Chiappini, C., Tasciotti, E., Fakhoury, J.R., Fine, D., Pullan, L.,Wang, Y.C., et al., 2010, Tailored porous silicon microparticles:Fabrication and properties, ChemPhysChem 11, 1029-1035.[Crossref][WoS]
  • [5] Godin, B., Chiappini, C., Srinivasan, S., Alexander, J.F., Yokoi,K., Ferrari, M., et al., 2012, Discoidal porous silicon particles:Fabrication and biodistribution in breast cancer bearing mice,Advanced Functional Materials 22, 4225-4235.[WoS][Crossref]
  • [6] Godin, B., Gu, J., Serda, R.E., Bhavane, R., Tasciotti, E., Chiappini,C., et al., 2010, Tailoring the degradation kinetics ofmesoporous silicon structures through PEGylation, Journal ofBiomedical Materials Research - Part A 94, 1236-1243.[WoS]
  • [7] Godin, B., Tasciotti, E., Liu, X., Serda, R.E., Ferrari, M., 2011,Multistage nanovectors: From concept to novel imaging contrastagents and therapeutics, Accounts of Chemical Research44, 979-989.[WoS][Crossref]
  • [8] Limnell, T., Santos, H.A., Mäkilä, E., Heikkilä, T., Salonen, J.,Murzin, D.Y., et al., 2011, Drug delivery formulations of orderedand nonordered mesoporous silica: Comparison of three drugloading methods, Journal of Pharmaceutical Sciences 100,3294-3306.[WoS][Crossref]
  • [9] Liu, W., Liu, J., Yang, X., Wang, K., Wang, Q., Yang, M., et al.,2013, pH and ion strength modulated ionic species loadingin mesoporous silica nanoparticles, Nanotechnology 24,415501.[Crossref]
  • [10] Low, S.P., Williams, K.A., Canham, L.T., Voelcker, N.H., 2006,Evaluation of mammalian cell adhesion on surface-modifiedporous silicon, Biomaterials 27, 4538-4546.[Crossref]
  • [11] Mattos, C., Ringe, D., 2001, Proteins in organic solvents, CurrentOpinion in Structural Biology 11, 761-764.[PubMed][Crossref]
  • [12] Prestidge, C.A., Barnes, T.J., Lau, C.H., Barnett, C., Loni, A.,Canham, L., 2007, Mesoporous silicon: A platform for thedelivery of therapeutics, Expert Opinion on Drug Delivery 4,101-110.[WoS][Crossref]
  • [13] Salonen, J., Laitinen, L., Kaukonen, A.M., Tuura, J., Björkqvist,M., Heikkilä, T., et al., 2005, Mesoporous silicon microparticlesfor oral drug delivery: Loading and release of five modeldrugs, Journal of Controlled Release 108, 362-374.[Crossref]
  • [14] Serda, R.E., Godin, B., Blanco, E., Chiappini, C., Ferrari, M.,2011, Multi-stage delivery nano-particle systems for therapeuticapplications, Biochimica et Biophysica Acta - GeneralSubjects 1810, 317-329.[WoS]
  • [15] Srinivasan, S., Alexander, J.F., Driessen, W.H., Leonard, F.,Ye, H., Liu, X., et al., 2013, Bacteriophage associated siliconparticles: Design and characterization of a novel theranosticvector with improved payload carrying potential, Journal ofMaterials Chemistry B 1, 5218-5229.[WoS]
  • [16] Tanaka, T., Godin, B., Bhavane, R., Nieves-Alicea, R., Gu, J.,Liu, X., et al., 2010, In vivo evaluation of safety of nanoporoussilicon carriers following single and multiple dose intravenousadministrations in mice, International Journal of Pharmaceutics402, 190-197.[WoS]
  • [17] Tasciotti, E., Liu, X., Bhavane, R., Plant, K., Leonard, A.D.,Price, B.K., et al., 2008, Mesoporous silicon particles as amultistage delivery system for imaging and therapeutic applications,Nature Nanotechnology 3, 151-157.[WoS][Crossref]
  • [18] Vallet-Regí, M., Balas, F., Arcos, D., 2007, Mesoporous materialsfor drug delivery, Angewandte Chemie - InternationalEdition 46, 7548-7558.[Crossref]
  • [19] Vallet-Regi, M., Rámila, A., Del Real, R.P., Pérez-Pariente, J.,2001, A new property of MCM-41: Drug delivery system, Chemistryof Materials 13, 308-311.[Crossref]
  • [20] Zendlová, L., Hobza, P., Kabelác, M., 2007, Stability of nucleicacid base pairs in organic solvents: Molecular dynamics,molecular dynamics/quenching, and correlated ab initiostudy, Journal of Physical Chemistry B 111, 2591-2609.[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_mesbi-2014-0002
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