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2014 | 1 | 1 |
Tytuł artykułu

Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures

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Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the effciency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages of the proposed method over the passive loading, especially when the difference between the dimensions of loaded materials and the pore diameter is small, an increase of up to 20-fold can be observed. The technique described in this study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical applications.
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  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
  • Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
  • Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
  • Houston Methodist Research Institute, Department of Nanomedicine, 6670 Bertner Ave, R7-122, Houston, TX 77030. Tel: 713-441-7329, Fax: 713-441-7438, Email:
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