PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 42 | 1 | 127-136
Tytuł artykułu

Interaction Between ACE I/D and ACTN3 R557X Polymorphisms in Polish Competitive Swimmers

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We hypothesized that the ACE ID / ACTN3 R577X genotype combination was associated with sprint and endurance performance. Therefore, the purpose of the present study was to determine the interaction between both ACE ID and ACTN3 R577X polymorphisms and sprint and endurance performance in swimmers. Genomic DNA was extracted from oral epithelial cells using GenElute Mammalian Genomic DNA Miniprep Kit (Sigma, Germany). All samples were genotyped using a real-time poly- merase chain reaction. The ACE I/D and the ACTN3 R577X genotype frequencies met Hardy-Weinberg expectations in both swimmers and controls. When the two swimmer groups, long distance swimmers (LDS) and short distance swimmers (SDS), were compared with control subjects in a single test, a significant association was found only for the ACE polymorphism, but not for ACTN3. Additionally, four ACE/ACTN3 combined genotypes (ID/RX, ID/XX, II/RX and II/XX) were statistically significant for the LDS versus Control comparison, but none for the SDS versus Control comparison. The ACE I/D and the ACTN3 R577X polymorphisms did not show any association with sprint swimming, taken individually or in combination. In spite of numerous previous reports of associations with athletic status or sprint performance in other sports, the ACTN3 R577X polymorphism, in contrast to ACE I/D, was not significantly associated with elite swimming status when considered individually. However, the combined analysis of the two loci suggests that the co-occurrence of the ACE I and ACTN3 X alleles may be beneficial to swimmers who compete in long distance races
Słowa kluczowe
Wydawca

Rocznik
Tom
42
Numer
1
Strony
127-136
Opis fizyczny
Daty
wydano
2014-10-01
online
2014-10-10
Twórcy
autor
  • Department of Physical Education and Sport, West Pomeranian Technological University, Szczecin, Poland
  • Faculty of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland.
  • Faculty of Tourism and Recreation, Academy of Physical Education and Sport, Gdansk, Poland
  • Faculty of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland
autor
  • University of Rzeszow, Department of Physical Culture, Rzeszow, Poland.
  • Faculty of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland
  • Institute of Sport in Warsaw, Poland
Bibliografia
  • Bray MS, Hagberg JM, Pérusse L, Rankinen T, Roth SM, Wolfarth B, Bouchard C. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc, 2009; 41: 35-73
  • Bustamante-Ara N, Santiago C, Verde Z, Yvert T, Gómez-Gallego F, Rodríguez-Romo G, González-Gil P, Serra-Rexach JA, Ruiz JR, Lucia A. ACE and ACTN3 genes and muscle phenotypes in nonagenarians. Int J Sports Med, 2010; 31: 221-224[WoS][Crossref]
  • Cam S, Colakoglu M, Colakoglu S, Sekuri C, Berdeli A. ACE I/D gene polymorphism and aerobic endurance development in response to training in a non-elite female cohort. J Sports Med Phys Fitnes, 2007; 47: 234-238
  • Charbonneau DE, Hanson ED, Ludlow AT, Delmonico MJ, Hurley BF, Roth SM. ACE genotype and the muscle hypertrophic and strength responses to strength training. Med Sci Sports Exerc, 2008; 40: 677-683[WoS][Crossref][PubMed]
  • Cięszczyk P, Eider J, Ostanek M, Arczewska A, Leońska-Duniec A, Sawczyn S, Ficek K, Krupecki K. Association of the ACTN3 R577X polymorphism in Polish power-orientated athletes. J Hum Kinet, 2011; 28: 55-61
  • Clarkson PM, Hoffman EP, Zambraski E, Gordish-Dressman H, Kearns A, Hubal M, Harmon B, Devaney JM. ACTN3 and MLCK genotype associations with exertional muscle damage. J Appl Physiol, 2005; 99: 564-569[PubMed][Crossref]
  • Costa AM, Silva AJ, Garrido ND, Louro H, de Oliveira RJ, Breitenfeld L. Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol, 2009; 106: 785-790[WoS][Crossref]
  • Costa AM, Silva AJ, Garrido N, Louro H, Marinho DA, Marques MC, Breitenfeld L. Angiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletes. J Sports Sci Med, 2009; 8: 410-418[PubMed]
  • Drozdovska SB, Dosenko VE, Ahmetov II, Ilyin VN. The association of gene polymorphisms with athlete status in Ukrainians. Biol Sport, 2013; 30: 163-167.[PubMed][Crossref][WoS]
  • Eynon N, Alves AJ, Yamin C, Sagiv M, Duarte JA, Oliveira J, Ayalon M, Goldhammer E, Sagiv M, Meckel Y. Is there an ACE ID - ACTN3 R577X polymorphisms interaction that influences sprint performance? Int J Sports Med, 2009; 30: 888-891[WoS]
  • Eynon N, Duarte JA, Oliveira J, Sagiv M, Yamin C, Meckel Y, Sagiv M, Goldhammer E. ACTN3 R577X polymorphism and Israeli top-level athletes. Int J Sports Med, 2009; 30: 695-698[WoS]
  • Ginevičien V, Pranculis A, Jakaitien A, Milašius K, Kučinskas V. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas), 2011; 47: 284-290
  • Grenda A, Leońska-Duniec A, Cięszczyk P, Zmijewski P. BDKRB2 gene -9/+9 polymorphism and swimming performance. Biol Sport, 2014; 31: 109-113[Crossref]
  • Kikuchi N, Min S, Ueda D, Igawa S, Nakazato K. Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res 2012; 26: 3275-3280[Crossref][WoS]
  • Kruk J. Good scientific practice and ethical principles in scientific research and higher education. Cent Eur J Sports Sci Med, 2013; 1: 25-29
  • MacArthur DG, North KN. ACTN3: A genetic influence on muscle function and athletic performance. Exerc Sport Sci Rev, 2007; 35: 30-34[Crossref][WoS][PubMed]
  • Macarthur DG, North KN. Genes and human elite athletic performance. Hum Genet, 2005; 116: 331-339[Crossref][PubMed]
  • Mills M, Yang N, Weinberger R, Woude DLV, Beggs AH, Easteal S, North KN. Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet, 2011; 10: 1335-1346
  • Nazarov IB, Woods DR, Montgomery HE, Shneider OV, Kazakov VI, Tomilin NV, Rogozkin VA. The angiotensin converting enzyme I/D polymorphism in Russian athletes. Eur J Hum Genet, 2001; 9: 797-801[Crossref][PubMed]
  • Niemi AK, Majamaa K. Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes. Eur J Hum Genet, 2005; 13: 965-969[Crossref]
  • North KN, Yang N, Wattanasirichaigoon D, Mills M, Easteal S, Beggs AH. A common nonsense mutation results in alpha-actinin-3 deficiency in the general population. Nat Genet, 1999; 21: 353-354
  • Orysiak J, Zmijewski P, Klusiewicz A, Kaliszewski P, Malczewska-Lenczowska J, Gajewski J, Pokrywka A. The association between ACE gene variation and aerobic capacity in winter endurance disciplines. Biol Sport, 2013; 30: 249-53[Crossref][PubMed][WoS]
  • Pereira A, Costa AM, Izquierdo M, Silva AJ, Bastos E, Marques MC. ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli. Age (Dordr), 2013; 35: 1949-1959[WoS][Crossref]
  • Phillips PC. Epistasis-the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet, 2008; 9: 855-867[WoS][Crossref][PubMed]
  • Pokrywka A, Kaliszewski P, Majorczyk E, Zembroń-Łacny A. Genes in sport and doping. Biol Sport, 2013; 30: 155-61[PubMed][Crossref]
  • Rieder MJ, Taylor SL, Clark AG, Nickerson DA. Sequence variation in the human angiotensin converting enzyme. Nat Genet, 1999; 22: 59-62[Crossref][PubMed]
  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin i-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest, 1990; 86: 1343-1346[PubMed][Crossref]
  • Ruiz JR, Santiago C, Yvert T, Muniesa C, Díaz-Urena G, Bekendam N, Fiuza-Luces C, Gómez-Gallego F, Femia P, Lucia A. ACTN3 genotype in Spanish elite swimmers: no "heterozygous advantage". Scand J Med Sci Sports, 2013; 23: 162-167[WoS][Crossref]
  • Toussaint HM, Vervoorn K. Effects of specific high resistance training in the water on competitive swimmers. Int J Sports Med, 1999; 11: 228-233
  • Tsianos G, Sanders J, Dhamrait S, Humphries S, Grant S, Montgomery H. The ACE gene insertion/deletion polymorphism and elite endurance swimming. Eur J Appl Physiol, 2004; 92: 360-362[PubMed]
  • Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P, Thomis MA. ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics, 2007; 32: 58-63[WoS]
  • Wang G, Mikami E, Chiu LL, Perini ADE, Deason M, Fuku N, Miyachi M, Kaneoka K, Murakami H, Tanaka M, Hsieh LL, Hsieh SS, Caporossi D, Pigozzi F, Hilley A, Lee R, Galloway SDR, Gulbin J, Rogozkin VA, Ahmetov II, Yang N, North KN, Ploutarhos S, Montgomery HE, Bailey MES, Pitsiladis YP. Association analysis of ACE and ACTN3 in elite Caucasian and east Asian swimmers. Med Sci Sports Exerc, 2013; 45: 892-900[WoS][Crossref]
  • Woods D, Hickman M, Jamshidi Y, Brull D, Vassiliou V, Jones A, Humphries S, Montgomery H. Elite swimmers and the d allele of the ACE I/D polymorphism. Hum Genet, 2001; 108: 230-232[Crossref]
  • Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, North K. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet, 2003; 73: 627-631 [PubMed][Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_hukin-2014-0067
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.