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2014 | 41 | 1 | 107-111
Tytuł artykułu

Changes in Urinary 8-Hydroxydeoxyguanosine Levels During Heptathlon Race in Professional Female Athletes

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Acute strenuous exercise can induce a state of oxidative stress affecting the involved muscles. Heptathlon is a multi-event exercise of two days duration and can be considered an acute, intensive endurance exercise. The purpose of this study is to compare the oxidative stress response to heptathlon events day by day and to determine the impact of this type of exercise on oxidative stress biomarkers. The study subjects included eight heptathlon athletes who participated in the National First Class Republic competition in Egypt (October 19-21, 2011). Blood samples were collected at rest after exercise for two successive days and analyzed for malondialdehyde (MDA). Morning urine samples were collected one hour after exercise for each day and were analyzed for 8-hydroxydeoxyguanosine (8-OHdG). Results revealed a significant increase (p<0.05) in both plasma MDA and urine 8-OHdG levels after exercise regardless of the day. We concluded that exercise generates higher MDA levels compared to DNA strand breaks and oxidative DNA damage in athletes with antioxidant supplementation.
Wydawca

Rocznik
Tom
41
Numer
1
Strony
107-111
Opis fizyczny
Daty
zaakceptowano
2013-12-01
online
2014-07-08
Twórcy
  • Faculty of medicine, Al Azhar University, Cairo, Egypt.
Bibliografia
  • Alessio M, Goldfarb AH, Cao G. Exercise-induced oxidative stress before and after vitamin C supplementation. Int J Sport Nutr,1997; 7(1): 1-9 Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med. Sci. Sports Exerc,2000; 32: 1576-1581
  • Banerjee AK, Mandal A, Chanda D, Chakraborti S. Oxidant, antioxidant and physical exercise. Mol Cell Biochem,2003; 253(1-2): 307-312
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  • Hartmann A, Pfuhler S, Dennog C, Germadnik D, Pilger A, Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2-deoxyguanosine or induction of micronuclei. Free Radic Biol Med,1998; 24(2): 245-251
  • Inoue T, Mu Z, Sumikawa K, Adachi K, Okochi T. Effect of physical exercise on the content of 8-hydroxydeoxyguanosine in nuclear DNA prepared from human lymphocytes. Japanese Journal ofCancer Research,1993; 84: 725-750
  • Martarelli D, Pompei P. Oxidative stress and antioxidant changes during a 24-hours mountain bike endurance exercise in master athletes. J. Sports Med. Phys. Fitness,2009; 49: 122-127
  • Powers SK, Jackson MJ. Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production. Physiol Rev,2008; 88: 1243-1276[WoS][PubMed][Crossref]
  • Radak Z, Taylor AW, Ohno H, Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev,2001; 7: 90-107[PubMed]
  • Sumida S, Doi TT, Sakurai M, Yoshioka Y, Okamura K. Effect of a single bout of exercise and beta-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans. Free Radic Res, 1997; 27: 607-618
  • Fisher-Wellman K, Bel HK, Bloomer RJ. Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders. Oxidative Medicine and Cellular Longevity, 2009; 2: 43-51
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_hukin-2014-0038
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