An Orchestrated Response To Tumor Signals By Macrophages and Mesenchymal Stem Cells Potentiates Interleukin-6 Secretion In Glioblastoma

• Autorzy: Kevin Anton , John Glod
• Języki publikacji: EN

Abstrakty

EN

The tumor microenvironment plays a critical role in the survival, growth, invasion, and metastasis of solid tumors. However, the mechanisms by which it influences these aspects of tumor progression remain incompletely characterized. In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). Macrophages and MSCs respond to tumor-secreted factors by increasing the release of interleukin-6 (IL-6) and this response is potentiated when macrophages and MSCs are combined in co-culture. In glioblastoma, IL-6 has been associated with tumor cell invasion, angiogenesis, tumor cell proliferation, immune suppression, and poor prognosis. Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors.

Słowa kluczowe

EN

Mesenchymal stem cell (MSC); Macrophage; Interleukin-6 (IL-6); Inflammatory; Microenvironment; Chemotaxis

• Czasopismo: Cell death in therapy
• Rocznik: 2014
• Tom: 1
• Numer: 1

Daty

otrzymano

2014-08-25

zaakceptowano

2014-10-06

online

2014-12-10

Twórcy

autor

Kevin Anton

• Departments of Pharmacology, The Cancer Institute
  of New Jersey, Robert Wood Johnson Medical School, University of
  Medicine and Dentistry of New Jersey, New Brunswick, NJ USA

autor

John Glod

• Departments of Pediatrics and
  Pharmacology, The Cancer Institute of New Jersey, Robert Wood
  Johnson Medical School, University of Medicine and Dentistry of
  New Jersey
• Pediatric Oncology Branch, National Cancer Institute,
  Bethesda

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Identyfikatory

DOI

10.2478/cdth-2014-0001