PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 1 | 1 |
Tytuł artykułu

An Orchestrated Response To Tumor Signals By Macrophages and Mesenchymal Stem Cells Potentiates Interleukin-6 Secretion In Glioblastoma

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The tumor microenvironment plays a critical role in the survival, growth, invasion, and metastasis of solid tumors. However, the mechanisms by which it influences these aspects of tumor progression remain incompletely characterized. In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). Macrophages and MSCs respond to tumor-secreted factors by increasing the release of interleukin-6 (IL-6) and this response is potentiated when macrophages and MSCs are combined in co-culture. In glioblastoma, IL-6 has been associated with tumor cell invasion, angiogenesis, tumor cell proliferation, immune suppression, and poor prognosis. Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors.
Wydawca
Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2014-08-25
zaakceptowano
2014-10-06
online
2014-12-10
Twórcy
autor
  • Departments of Pharmacology, The Cancer Institute
    of New Jersey, Robert Wood Johnson Medical School, University of
    Medicine and Dentistry of New Jersey, New Brunswick, NJ USA
autor
  • Departments of Pediatrics and
    Pharmacology, The Cancer Institute of New Jersey, Robert Wood
    Johnson Medical School, University of Medicine and Dentistry of
    New Jersey
  • Pediatric Oncology Branch, National Cancer Institute,
    Bethesda
Bibliografia
  • [1] Wheeler SE, Shi H, Lin F et al. Enhancement of head andneck squamous cell carcinoma proliferation, invasion, andmetastasis by tumor-associated fibroblasts in preclinicalmodels. Head Neck. 2013.
  • [2] Anton K, Glod J. Targeting the tumor stroma in cancer therapy.Curr Pharm Biotechnol. 2009;10:185-191.[WoS][Crossref]
  • [3] Horimoto Y, Polanska UM, Takahashi Y et al. Emerging roles ofthe tumor-associated stroma in promoting tumor metastasis.Cell Adh Migr. 2012;6:193-202.[Crossref][WoS]
  • [4] Rossi ML, Hughes JT, Esiri MM et al. Immunohistological studyof mononuclear cell infiltrate in malignant gliomas. ActaNeuropathol. 1987;74:269-277.[Crossref]
  • [5] Frei K, Piani D, Malipiero UV et al. Granulocyte-macrophagecolony-stimulating factor (GM-CSF) production by glioblastomacells. Despite the presence of inducing signals GM-CSF is notexpressed in vivo. J Immunol. 1992;148:3140-3146.
  • [6] Nishie A, Ono M, Shono T et al. Macrophage infiltration andheme oxygenase-1 expression correlate with angiogenesis inhuman gliomas. Clin Cancer Res. 1999;5:1107-1113.
  • [7] Gouon-Evans V, Lin EY, Pollard JW. Requirement of macrophagesand eosinophils and their cytokines/chemokines for mammarygland development. Breast Cancer Res. 2002;4:155-164.[Crossref]
  • [8] Zhang BC, Gao J, Wang J et al. Tumor-associated macrophagesinfiltration is associated with peritumoral lymphangiogenesisand poor prognosis in lung adenocarcinoma. Med Oncol.2011;28:1447-1452.[Crossref][WoS]
  • [9] Luo Y, Zhou H, Krueger J et al. Targeting tumor-associatedmacrophages as a novel strategy against breast cancer. J ClinInvest. 2006;116:2132-2141.[Crossref]
  • [10] Sierra JR, Corso S, Caione L et al. Tumor angiogenesis andprogression are enhanced by Sema4D produced by tumorassociatedmacrophages. J Exp Med. 2008;205:1673-1685.[WoS]
  • [11] Mills CD, Kincaid K, Alt JM et al. M-1/M-2 macrophages and theTh1/Th2 paradigm. J Immunol. 2000;164:6166-6173.
  • [12] Laoui D, Van Overmeire E, De Baetselier P et al. FunctionalRelationship between Tumor-Associated Macrophages andMacrophage Colony-Stimulating Factor as Contributors toCancer Progression. Frontiers in immunology. 2014;5:489.
  • [13] Martinez FO, Gordon S. The M1 and M2 paradigm ofmacrophage activation: time for reassessment. F1000primereports. 2014;6:13.
  • [14] Van Overmeire E, Laoui D, Keirsse J et al. Mechanisms drivingmacrophage diversity and specialization in distinct tumormicroenvironments and parallelisms with other tissues.Frontiers in immunology. 2014;5:127.[WoS]
  • [15] Mishra PJ, Humeniuk R, Medina DJ et al. Carcinoma-associatedfibroblast-like differentiation of human mesenchymal stemcells. Cancer Res. 2008;68:4331-4339.[Crossref]
  • [16] Jia CC, Wang TT, Liu W et al. Cancer-associated fibroblasts fromhepatocellular carcinoma promote malignant cell proliferationby HGF secretion. PLoS One. 2013;8:e63243.
  • [17] Kim SH, Choe C, Shin YS et al. Human lung cancer-associatedfibroblasts enhance motility of non-small cell lung cancer cellsin co-culture. Anticancer Res. 2013;33:2001-2009.
  • [18] Yu B, Chen X, Li J et al. Stromal fibroblasts in the microenvironmentof gastric carcinomas promote tumor metastasis viaupregulating TAGLN expression. BMC Cell Biol. 2013;14:17.[Crossref][WoS]
  • [19] Bababeygy SR, Cheshier SH, Hou LC et al. Hematopoietic stemcell-derived pericytic cells in brain tumor angio-architecture.Stem Cells Dev. 2008;17:11-18.[Crossref][WoS]
  • [20] Comito G, Giannoni E, Segura CP et al. Cancer-associatedfibroblasts and M2-polarized macrophages synergize duringprostate carcinoma progression. Oncogene. 2013.[WoS]
  • [21] Anton K, Banerjee D, Glod J. Macrophage-AssociatedMesenchymal Stem Cells Assume an Activated, Migratory,Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10Secretion. PLoS One. 2012;7:e35036.
  • [22] Komohara Y, Ohnishi K, Kuratsu J et al. Possible involvement ofthe M2 anti-inflammatory macrophage phenotype in growth ofhuman gliomas. J Pathol. 2008;216:15-24.[WoS]
  • [23] Pyonteck SM, Akkari L, Schuhmacher AJ et al. CSF-1R inhibitionalters macrophage polarization and blocks glioma progression.Nat Med. 2013;19:1264-1272.[Crossref][WoS]
  • [24] Balyasnikova IV, Ferguson SD, Sengupta S et al. Mesenchymalstem cells modified with a single-chain antibody againstEGFRvIII successfully inhibit the growth of human xenograftmalignant glioma. PLoS One. 2010;5:e9750.
  • [25] Roger M, Clavreul A, Venier-Julienne MC et al. Mesenchymalstem cells as cellular vehicles for delivery of nanoparticles tobrain tumors. Biomaterials. 2010;31:8393-8401.[WoS][Crossref]
  • [26] Hai C, Jin YM, Jin WB et al. Application of mesenchymal stemcells as a vehicle to deliver replication-competent adenovirusfor the treatment of malignant glioma. Chin J Cancer. 2012.[WoS]
  • [27] Chang CY, Li MC, Liao SL et al. Prognostic and clinicalimplication of IL-6 expression in glioblastoma multiforme. J ClinNeurosci. 2005;12:930-933.
  • [28] Kudo M, Jono H, Shinriki S et al. Antitumor effect of humanizedanti-interleukin-6 receptor antibody (tocilizumab) on gliomacell proliferation. Laboratory investigation. J Neurosurg.2009;111:219-225.[WoS]
  • [29] Wang H, Lathia JD, Wu Q et al. Targeting interleukin 6 signalingsuppresses glioma stem cell survival and tumor growth. StemCells. 2009;27:2393-2404.[WoS]
  • [30] Mishra PJ, Banerjee D. Activation and differentiation ofmesenchymal stem cells. Methods Mol Biol. 2011;717:245-253.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_cdth-2014-0001
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.