Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
Background: To evaluate whether salivary lead can be used as a surrogate for blood lead, and if so, over what concentration range. Methodology: Three saliva devices were evaluated and one chosen to undertake this project. Paired saliva and blood samples were collected from 89 UK lead workers. Lead concentrations were determined using ICP-MS. In addition, haemoglobin and ZPP levels were determined in the blood samples and albumin was determined in the saliva samples to investigate standardisation using protein adjustments. Results: The chosen saliva device gave low but consistent recoveries for lead in saliva and the blank levels were low. The mean +/- SD blood lead level was 19.9 +/- 14 μg/dl; the mean +/- SD saliva lead level was 19.1 +/- 32.5 μg/l for 89 workers. Log10-transformed data showed correlation of r=0.69. The protein adjustments did not improve the blood-saliva correlation. Conclusions: This study has demonstrated that salivary lead measurement is feasible and correlated with blood lead levels, at least at occupational exposure levels, and may have value as a screening technique. Correlation may improve at environmental levels where exposures are generally more consistent and chronic, although this needs to be demonstrated in a genuine environmental population.
Czasopismo
Rocznik
Tom
Numer
Opis fizyczny
Daty
otrzymano
2014-06-19
zaakceptowano
2014-09-11
online
2014-10-03
Twórcy
autor
-
Health and Safety
Laboratory, Harpur Hill, Buxton, SK17 9JN, UK, jackie.morton@hsl.gsi.gov.uk
autor
-
Health and Safety
Laboratory, Harpur Hill, Buxton, SK17 9JN, UK
autor
-
Health and Safety
Laboratory, Harpur Hill, Buxton, SK17 9JN, UK
autor
-
Health and Safety
Laboratory, Harpur Hill, Buxton, SK17 9JN, UK
autor
-
Public Health England, Centre for Radiation Chemical
and Environmental Hazards, Didcot, OX11 0RQ
Bibliografia
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- [13] Koh D., Ng V., Chua L.H., Yang Y., Ong H.Y., Chia S.E., Cansalivary lead be used for biological monitoring of lead exposedindividuals?, J Occup Environ Med, 2003, 60, 696-8.
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- [15] Barbosa Jr F., Rodrigues M.H.C., Buzalaf M.R., Krug F.J., GerlachR.F., Tanus-Santos J.E. Evaluation of the use of salivary leadlevels as a surrogate of blood lead or plasma lead levels in leadexposed subjects, Arch Toxicol, 2006, 80, 633-637.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_bimo-2014-0008