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2004 | 2 | 4 | 696-702
Tytuł artykułu

QSAR studies of 2-substituted 2,3-dihydro-1h-naphtho[1,8-de]-1,3,2-diazaphosphorine 2-oxides and sulphides

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A quantitative structure activity relationship (QSAR) study of 2-substituted 2,3-dihydro-1H-naphtho[1,8,de]-1,3,2-diazaphosphorine 2-oxides and sulphides (DND), examines the extent of the contribution by various physicochemical parameters with respect to their antimicrobial activity. Simple bivariant regression analysis, based on the least squares method, is applied in order to predict models. The predicted models reveal that the steric factor, MR, is the major contributor influencing antimicrobial activity. Bulky groups at the C-19 (C=0 group) position positively influence the potency of the compounds
Wydawca

Czasopismo
Rocznik
Tom
2
Numer
4
Strony
696-702
Opis fizyczny
Daty
wydano
2004-12-01
online
2004-12-01
Twórcy
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India
autor
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India
autor
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India, umavuruputuri@yahoo.co.in
Bibliografia
  • [1] O.M. Freidman, E. Boger, V. Gublianskar and H. Sommer: “Synthesis of N-Phoshorylated Derivatives of Nitrogen Mustards with latent cytotoxicity”,Journal of Medicinal Chemistry, Vol. 6, (1963), pp. 50. http://dx.doi.org/10.1021/jm00337a012[Crossref]
  • [2] H. Zimmer and A. Sill: “Potential Anticancer Agents (iv) Heterocyclic Phospharamide Nitrogen-Mustards”,Arzneimittel Forschung Drug Research (Progressive Drug Research), Vol. 5, (1964), pp. 150.
  • [3] H. Arnold and F. Bourseaux: “Synthesis Und Abbau Cytoststisch Wirksamer Cyclischer N-phosphamidester des Bis-(ß-Chloräthyl)-Amins”,Angewante Chemie, Vol. 70, (1958), pp. 539.
  • [4] R.I. Zhadanov, W.A. Buina, N.A. Kapitnova and I.A. Nuretdinov: “Biologically Active Stable Radicals XV: Spin-labeled Alkyl Carbamate-N-Phosphori Acid Aziridides,” Sysnthesis, Vol. 1, (1979), pp. 269. http://dx.doi.org/10.1055/s-1979-28640[Crossref]
  • [5] C. Fest and K.J. Schmidt: “Reactivity, Synthesis, Mode of action, Toxicology”, In: The Chemistry of Organophosphorus Pesticides, Springer Verlag, New York, 1973, pp. 12.
  • [6] M.S. Bhatia and P. Jit: “Phosphorous-Containing Heterocycles as Fungicides: Synthesis of 2,2'-Dyphenylene Chlorophosphonate and 2,2-DiphenyleneChlorothiophosphonate,” Experientia, Vol. 32, (1976), pp. 1111. http://dx.doi.org/10.1007/BF01927572[Crossref]
  • [7] R. Ismail: “Benzocondensed 1,3,2 Dioxaphosphacycloalkanes,” German patents, 1 543 539, (1975)
  • [8] A.V. Kirsanov: “Chlorides of Iscocynatophosphoric Acid,” Zhur Obshchei Khim, Vol. 24, (1954), pp. 1033.
  • [9] A.V. Kirsanov and I.N. Zhumrova: “Reaction of Phosphorus Pentachloride with Amides of Phosphoric Acid”,Zhur Obshchei Khim, Vol. 28 (1958), pp. 2478.
  • [10] A.V. Kirsanov and M.S. Marenets: “Esters of Urethanphosphoric Acids,” Zhur Obshchei Khim, Vol. 29, (1959), pp. 2256.
  • [11] H. Arnold, F. Bourseaux and N. Brock: “Chemotherapeutic Action of a Cyclic Nitrogen Mustard Phosphamide Ester (B 518-ASTA) in Experimental Tumours ofthe Rat”,Nature, Vol. 181, (1958), pp. 931. http://dx.doi.org/10.1038/181931a0[Crossref]
  • [12] S.M. Ludeman and G. Zon: “Synthesis and antitumour Activity of Cyclophosphomide Analogs. 1. Benzo Annulated Cyclophosphamide and Related Systems”,Journal of Medicinal Chemistry, Vol. 18, (1975), pp. 251. http://dx.doi.org/10.1021/jm00246a017[Crossref]
  • [13] C.M. Thompson, J.A. Frick and D.L.C. Green: “Synthesis, Configuration and Chemical Shift Correlations of Chiral 1,3,2-Oxazophospholidin-2-one Derived from l-Serine”,Journal of Organic Chemistry, Vol. 55, (1990), pp. 111. http://dx.doi.org/10.1021/jo00288a023[Crossref]
  • [14] R. Martino, V. Gillard, M.M. Martino, U. Neimayer and J. Phol: “Chemical Stability and Fate of the Cytostatic Drug Ifosfamide and its N-Dechloroethylated Metabolites in Acidic Aqueous Solutions”,Journal of Medicinal Chemistry, Vol. 42 (1999), pp. 2542. http://dx.doi.org/10.1021/jm980587g[Crossref]
  • [15] M. Venugopal, C. Devendranath Reddy and M. Bavaji: “Sysnthesis and Antimicrobial activity of “2-Substituted-2,3-Dihydro-1H-Naptho-[1,8-de]-1,3,2-Diazaphosphorine 2-Oxides/Sulphides”,Indian Journal of Chemistry, Vol. 40B, (2001), pp. 822–827.
  • [16] ChemSW Inc: MolecularModelingPro, version 3.24, 420F Executive Ct.North, Fairfeild, CA 94585; http://www.Chemsw.com.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_BF02482732
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