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2015 | 87 | 6 | 283-289
Tytuł artykułu

The “biological chamber” method – use of autologous platelet-rich plasma (PRP) in the treatment of poorly healing lower-leg ulcers of venous origin

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Wound healing is a complex pathophysiological process, in which platelets play a crucial role. Platelet alpha-granules release growth factors to the wound bed; the factors are necessary in the healing process. In chronic wounds, such as poorly healing lower-leg ulcers of venous origin, there is decreased activity of multiple growth factors, so the concept of exogenous delivery of such factors seems a logical strategy. Platelet-rich plasma therapy in patients with lower-leg ulcers of venous origin combined with conventional treatment methods (previously ineffective in these patients) seems, based on our observation, an important adjunct leading to recovery. The aim of the study was to present an original method of autologous platelet-rich plasma application through the creation of a sort of “biological chamber” containing a concentrate of growth factors. Material and methods. The described therapy was implemented in 10 patients, who had been ineffectively treated for more than one year in the outpatient setting. Patients with exacerbation of inflammatory process, signs of wound infection and ankle brachial pressure index < 0.8 were excluded from the study. After the application of platelet-rich plasma, further treatment was continued with the use of moist therapy and compression therapy according to a uniform regimen. Results. Complete healing was achieved within 4-10 weeks from the beginning of the product administration in all patients. Conclusion. The presented method seems technically simple, effective and relatively inexpensive
Wydawca
Rocznik
Tom
87
Numer
6
Strony
283-289
Opis fizyczny
Daty
wydano
2015-06-01
otrzymano
2015-05-19
online
2015-08-04
Twórcy
  • Institute of Surgical Propaedeutics, Department of General, Colorectal and Multiorgan Trauma Surgery, Faculty of Health Sciences, Silesian Medical University in Katowice1 Kierownik: dr n. med. D. Waniczek , dariusz_waniczek@interia.pl
  • Institute of Surgical Propaedeutics, Department of General, Colorectal and Multiorgan Trauma Surgery, Faculty of Health Sciences, Silesian Medical University in Katowice
  • Department of Physiological-Medical Sciences, Faculty of Physical Education, Academy of Physical Education in Katowice2
  • Department of General, Colorectal and Multiple-Organ Surgery, Faculty of Health Sciences, Silesian Medical University in Katowice
  • Department of General, Colorectal and Multiple-Organ Surgery, Faculty of Health Sciences, Silesian Medical University in Katowice
  • Department and Clinic of Craniomaxillofacial Surgery, Silesian Medical University in Katowice
Bibliografia
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  • 6. Lacci KM, Dardik A: Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med 2010; 83: 1‑9.
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  • 8. Li GY, Yin JM, Ding H et al.: Efficacy of leukocyte - and platelet rich plasma gel (L-PRP gel) in treating osteomyelitis in a rabbit model. J Orthop Res 2012 Dec 31. doi: 10.1002/jor.22299.
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  • 10. Everts PA, Hoffmann J, Weibrich G et al.: Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med 2006; 16(5): 363‑68.
  • 11. Slesaczeck T, Paetzold H, Nanning T et al.: Autologous derived, platelet-rich plasma gel in the treatment of nonhealing diabetic foot ulcer: a case report Ther Adv Endocrinol Metab 2012 April; 3(2): 75‑78. doi: 10.1177/2042018812438213
  • 12. Frykberg RG., Driver VR., Carman D et al.: Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage 2010; 56: 36‑44.
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  • 14. de Leon JM, Driver VR, Fylling CP et al.: The clinical relevance of treating chronic wounds with an enhanced near-physiological concentration of platelet-rich plasma gel. Adv Skin Wound Care 2011 Aug; 24(8): 357‑68. doi: 0.1097/01.ASW.0000403249.85131.6f.
  • 15. Anitua E, Andia I, Ardanza B et al.: Autologus platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91: 4‑15.
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  • 18. Scimeca, C, Bharara M, Fisher T et al.: Novel Use of Platelet-Rich Plasma to Augment Curative Diabetic Foot Surgery. J Diabetes Sci Technol 2010; 4: 1121‑26.
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  • 20. Knighton DR, Ciresi KF, Fiegel VD et al.: Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF).Ann Surg 1986; 204(3): 322‑30.
  • 21. Krupski WC, Reilly LM, Perez S et al.: A prospective randomized trial of autologous platelet-derived wound healing factors for treatment of chronic nonhealing wounds: a preliminary report. J Vasc Surg 1991; 14(4): 526‑32; discussion 532‑36.
  • 22. Waniczek D, Kozowicz A, Muc-Wierzgoń M et al.: Adjunct methods of the standard diabetic foot ulceration therapy. Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine (2013) Article ID 243568, 12 pages.
  • 23. Driver VR, Hanft J, Fylling CP: Autologel Diabetic Foot Ulcer Study GroupA prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers.Ostomy Wound Manage 2006 Jun; 52(6): 68‑70, 72, 74 passim.
  • 24. Margolis DJ, Kantor J, Santanna J et al.: Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2001 Mar; 24(3): 483‑88.
  • 25. Saldalamacchia G, Lapice E, Cuomo V et al.: A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers. Nutr Metab Cardiovasc Dis 2004 Dec; 14(6): 395‑96.
  • 26. Villela DL, Santos VL: Evidence on the use of platelet-rich plasma for diabetic ulcer: a systematic review. Growth Factors. 2010 Apr; 28(2): 111‑16. doi: 10.3109/08977190903468185.
  • 27. Dougherty EJ: An Evidence-Based Model Comparing the Cost-effectiveness of Platelet-Rich Plasma Gel to Alternative Therapies for Patients with Nonhealing Diabetic Foot Ulcers. Adv Skin Wound Care 2008; 21(12): 568‑75.
  • 28. O’Connell SM, Impeduglia T, Hessler K et al.: Autologus platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers.Wound Rep Reg 2008; 16: 749‑56.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_pjs-2015-0055
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