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2015 | 87 | 2 | 83-85
Tytuł artykułu

The Role of the XPF Gene Polymorphism (Xrcc4) Ser835ser in the Risk of Malignant Transformation of Cells in the Colorectal Cancer

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Participation of DNA repair systems in the pathogenesis of cancer has been a suspected phenomenon for a long time. Decreased efficiency in DNA repair translates to their ability to fix and consequently leads to mutations and the process of carcinogenesis. Linking individual polymorphisms of DNA repair systems with an increased risk of colorectal cancer will allow the classification of patients to high-risk groups and their placement under preventive program. The aim of the study was to determine the effect of XPF gene polymorphism Ser835Ser on increasing the risk of colorectal cancer in the Polish population. Material and methods. as the material blood collected from 146 patients diagnosed with colon cancer was used. The control group consisted of 149 healthy subjects. Genotyping was performed by Taq- Man method. Results. The results indicate that genotype TCC/TCT is associated with an decreased risk of colorectal cancer (OR 0.574; CI 95% 0.335-0.984; p=0.043). Conclusions. Based on these results, we conclude that the XPF gene polymorphism Ser835Ser may be associated with a decreased risk of colorectal cancer
Słowa kluczowe
Wydawca
Rocznik
Tom
87
Numer
2
Strony
83-85
Opis fizyczny
Daty
wydano
2015-02-01
otrzymano
2015-01-31
online
2015-07-03
Twórcy
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź
Bibliografia
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  • 2. Eshleman JR, Markowitz SD: Mismatch repair defects in human carcinogenesis. Human molecular genetics 5 1996, Supplement, 1489-94.
  • 3. Sanyal S, Festa F, Sakano S et al. Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis 2004; 25 (5): 729-34.
  • 4. López-Cima MF, Gonzales-Arriaga P, Garcia- Castro L et al.: Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain.” BMC cancer 2007; 7 (1): 162.
  • 5. Försti A, Angelinis S, Festa F et al.: Single nucleotide polymorphisms in breast cancer.” Oncology reports 2004; 11(4): 917-22.
  • 6. Shen H, Sturgis KM, Khan SG et al.: An Intronic Poly (AT) Polymorphism of the DNA Repair Gene XPC and Risk of Squamous Cell Carcinoma of the Head and Neck A Case-Control Study.” Cancer research 2001; 61 (8): 3321-25.
  • 7. Butkiewicz D, Rusin M, Enewold L et al.: Genetic polymorphisms in DNA repair genes and risk of lung cancer.” Carcinogenesis 2001; 22(4): 593-97.
  • 8. Chikako Kiyohara, Kouichi Yoshimasu: Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis. International J Med Scien 2007; 4(2): 59.
  • 9. Smith TR , Levine EA , Perrier ND et al.: DNArepair genetic polymorphisms and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2003; 12(11): 1200-04.
  • 10. Mort R, Mo L, McEwan C, Melton DW: Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. Br J Cancer 2003; 89(2): 333-37.
  • 11. Goode EJ., Ulrich CM, Potter JD: Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiology Biomarkers & Prevention 2002; 11(12): 1513-30.
  • 12. Chen J, Ma J, Stampfer MJ et al.: Linkage disequilibrium between the 677C> T and 1298A> C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics and Genomics 2002; 12(4): 339-42.
  • 13. Schabath MB, Spitz MR, Hong WK et al.: A myeloperoxidase polymorphism associated with reduced risk of lung cancer. Lung cancer 2002; 37(1): 35-40.
  • 14. Turnbull C, Seal S, Renwick A et al.: Gene-gene interactions in breast cancer susceptibility. Human molecular genetics 2011; ddr525.
  • 15. Cordell HJ: Detecting gene-gene interactions that underlie human diseases. Nature Reviews Genetics 2009; 10(6): 392-04.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_pjs-2015-0023
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