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2015 | 87 | 2 | 59-64
Tytuł artykułu

Expression of the PLS3 Gene in Circulating Cells in Patients with Colorectal Cancer

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Circulating tumor cells (CTC) are cells in circulating blood that have the antigen and gene features of tumor cells of a specific type. Since they can be potentially used in diagnostics and monitoring of treatment of many tumors, they have been attracting attention of researchers worldwide. Plastin-3 (PL S3) is one of such markers of CTC. The aim of the study was to assess expression of PL S3 in CTC in patients with colorectal cancer, to conduct a statistical analysis and to demonstrate a link between expression of PL S3 and progress of the disease, level of CEA and Ca19-9 markers, gender and age of the patients. Material and methods. A group of 85 patients of the Department of General and Colorectal Surgery of the Medical University in Łódź were enrolled in this study. Circulating tumor cells were isolated from whole blood of patients with colorectal cancer and an analysis of PL S3 gene expression in CTC was conducted. The next step was to conduct a statistical analysis and to demonstrate a link between expression of PL S3 in patients’ CTC and progress of the disease, level of CEA and Ca19-9 markers, gender and age of the patients. Results. PL S3 is a marker which can be potentially used in prediction and monitoring of colorectal cancer. A link between expression of PL S3 in CTC of patients with colorectal cancer and metastasis to lymph nodes has been demonstrated. It may be of key importance how PL S3 could impact the qualification to supplementary cancer treatment in patients with stage II colorectal cancer. A link between expression of PL S3 gene in CTC and gender requires further in-depth studies. It is beyond doubt that PL S3 must be further investigated to determine its role in diagnostics, prediction, treatment and monitoring of treatment of colorectal cancer
Słowa kluczowe
Wydawca
Rocznik
Tom
87
Numer
2
Strony
59-64
Opis fizyczny
Daty
wydano
2015-02-01
online
2015-07-03
Twórcy
  • Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki , ryszard.kujawski@gmail.com
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź Kierownik: prof. dr hab. I. Majsterek
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź1 Kierownik: prof. dr hab. A. Dziki
  • Department of General and Colorectal Surgery, Medical University in Łódź1 Kierownik: prof. dr hab. A. Dziki
  • Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki
  • Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź Kierownik: prof. dr hab. I. Majsterek
autor
  • Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki
Bibliografia
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  • 3. Paterlini-Brechot P, Benali NL : Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett 2007; 253: 180-204.
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  • 6. Gurtowska N, Bajek A, Olkowska J et al.: Identification of circulating tumor cells as a promising method of genitourinary cancer diagnosis. Postepy Hig Med Dosw (Online). 2012; 66: 983-90.
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  • 15. Sastre J, Maestro ML, Puente J et al.: Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables. Ann Oncol 2008; 19: 935-38.
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  • 19. Yokobori T, Iinuma H, Shimamura T et al.: Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. Cancer Res 2013; 73(7): 2059-69.
  • 20. Ning Y, Gerger A, Zhang W et al.: Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy. Mol Cancer Ther 2014; 13(2): 528-39.
  • 21. Szkandera J, Winder T, Stotz M et al.: A common gene variant in PLS3 predicts colon cancer recurrence in women. Tumour Biol 2013: 34(4): 2183-88.
  • 22. Sugimachi K, Yokobori T, Iinuma H et al.: Aberrant expression of plastin-3 via copy number gain induces the epithelial-mesenchymal transition in circulating colorectal cancer cells. Ann Surg Oncol 2014: 21(11): 3680-90.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_pjs-2015-0020
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