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2015 | 13 | 1 |
Tytuł artykułu

Evaluation of absorbed dose in Gadolinium neutron capture therapy

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Gadolinium neutron capture therapy (GdNCT) is used for treatment of radioresistant malignant tumors. The absorbed dose in GdNCT can be divided into four primary dose components: thermal neutron, fast neutron, photon and natural gadolinium doses. The most significant is the dose created by natural gadolinium. The amount of gadolinium at the irradiated region is changeable and depends on the gadolinium delivery agent and on the structure of the location where the agent is injected. To de- fine the time dependence of the gadolinium concentration ρ(t) in the irradiated region the pharmacokinetics of gadolinium delivery agent (Magnevist) was studied at intratumoral injection in mice and intramuscular injection in rats. A polynomial approximation was applied to the experimental data and the influence of ρ(t) on the relative change of the absorbed dose of gadolinium was studied.
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
13
Numer
1
Opis fizyczny
Daty
otrzymano
2014-06-20
zaakceptowano
2015-01-01
online
2015-02-27
Twórcy
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
autor
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
autor
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
  • Institute
    of Nuclear Physics Uz AS, Tashkent, Uzbekistan
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_phys-2015-0022
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