PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2015 | 52 | 3 | 71-73
Tytuł artykułu

Autophagy - Adaptive Molecular Mechanisms in Condition of Starvation

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Autophagy is an extremely old process during which long-lived proteins and cellular organelles are removed by means of lysosomes. Autophagy may be caused by cellular stress mechanisms. Research has proven that autophagy plays a key role in obtaining nutrients and adapting to the conditions of starvation. Owing to this, it takes part in maintaining homeostasis in cytoplasm and cell nucleus. This objective may be achieved through a number of ways. Depending on the manner in which a substrate connects with the lysosome, we can talk about macroautophagy and microautophagy. Additionally, some authors also distinguish a chaperone-mediated autophagy. The article presented below describes molecular mechanisms of each type of autophagy and focuses particularly on macroautophagy, which is the best understood of all the autophagy types.
Słowa kluczowe
Wydawca
Rocznik
Tom
52
Numer
3
Strony
71-73
Opis fizyczny
Daty
wydano
2015-09-01
otrzymano
2015-06-05
zaakceptowano
2015-07-20
online
2015-12-30
Twórcy
  • Departament of Histology and Embryology Medical University in Lublin ul. Radziwiłłowska 11 20-080, Lublin, Poland , apw4@wp.pl
  • Departament of Histology and Embryology Medical University in Lublin, Poland
  • Departament of Histology and Embryology Medical University in Lublin, Poland
Bibliografia
  • 1. Allyson L., Anding, Eric H. Baehrecke.: Autophagy in Cell Life and Cell Death. www.sciencedirect.com/science/article/pii/S0070215315000484, 2015
  • 2. Baran P.: Death types analysis of liver hepatocytes in pregnant female rats induced by the preeclampsia imposed on the nephrotic syndrome. Doctoral thesis 2013
  • 3. Clausen T.H., Lamark T., Isakson P., Finley K., Larsen K.B., Brech A., Overvatn A., Stenmark H., Bjorkoy G., Simonsen A., Johansen T.: p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy, 6: 330-344; 2010: [WoS][Crossref]
  • 4. Dunlop E.A, Tee A.R. :.mTOR and autophagy: A dynamic relationship governed by nutrients and energy. Semin Cell Dev Biol, 36: 121-129; 2014: [WoS][Crossref]
  • 5. Kamada Y., Funakoshi T., Shintani T., NeganoK., Oshumi M., Oshumi Y.: Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol. , 150: 1507-1513; 2000:
  • 6. Ketteler R., Seed B.: Quantitation of autophagy by luciferase release assay. Autophagy, 4: 801-806; 2008: [Crossref][WoS]
  • 7. Klionsky D.J.: Autophagy revisited: a conversation with Christian de Duve. Autophagy. 4: 740-743; 2008: [Crossref]
  • 8. Klionsky D., Gregg J., Dunn W., Emr S., Sakai Y., Sandoval I., Sibirny A., Subramani S., Thumm M., Veenhuis M.: A unified nomenclature for yeast autophagy-related genes. Dev Cell. 5: 539-545,2003[Crossref]
  • 9. Lamparska-Przybysz M., Motyl T.: Autophagy: a tool for survival or death of a tumour cell. Post Biol Kom. 32: 13-22; 2005:
  • 10. Luneman JD., Munz C.: Autophagy in CD4+ T-cell immunity and tolerance. Cell death different.16: 79-85; 2009:
  • 11. Ohsumi Y.: Mollecular dissection of autophagy:two ubiquitin-like systems. Nat.Rev.Mol. Cell. Biol., 2:211-216, 2001[Crossref]
  • 12. Ostrowski K; Histologia ed. II 667-669,1995
  • 13. Papinski D., Schusching M., Reiter W., Wilhelm L., Barnes C. A., Maiolica A., et.all: Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Mol Cell, 53: 471-483; 2014: [WoS][Crossref]
  • 14. Polewska J.: Autophagy- molecular mechanizm, apoptosis and cancer. Post Hig Med Dosw; 66: 921-936; 2012:
  • 15. Reggiori F., KilionskyD.J.: Autophagy in the Eukaryotic Cell. Eucaryotic Cell. 1: 11-21; 2002:
  • 16. Rudnicka K.W., Szczęsna E., Miszczyk E., Mikołajczyk-Chmiela M.: Apoptosis and Autophagy - mechanisms and methods of detection. Post Biol Komórki 38: 247-265; 2006:
  • 17. Świderek E, Strządała L.: Autophagy and the BNIP3 protein in neoplasms. Advances in Hygiene and Experimental Medicine, 67: 363-370; 2013
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_phr-2015-0018
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.