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2015 | 2 | 1 |
Tytuł artykułu

Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Amyotrophic Lateral Sclerosis (ALS) has often been associated with improper/altered metal metabolism. Analysis of thiophylic metals in serum from a small and geographically restricted cohort of ALS patients indicates contents of Pb and Ni much higher in patients than in controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in the patients’ group, which has instead lower As levels than controls. Thiophylic metals may impair biogenesis of FeS clusters or substitute for iron, even in folded proteins; Se may non-functionally replace S. Thus, improper assembly/ function of FeS proteins could represent another possible issue to be considered in ALS pathogenesis.
Wydawca

Czasopismo
Rocznik
Tom
2
Numer
1
Opis fizyczny
Daty
otrzymano
2015-07-28
zaakceptowano
2015-10-16
online
2016-01-20
Twórcy
  • Department of Food, Environmental
    and Nutritional Sciences (DeFENS), University of Milan,
    20133 Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • Department of Agricultural and Environmental
    Sciences (DiSAA), University of Milan, 20133 Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • NEuroMuscular Omnicentre (NEMO), Fondazione
    Serena Onlus, Niguarda Ca’ Granda Hospital, 20169, Milan, Italy
  • DeFENS, University of
    Milan, Via Celoria 2, 20133, Milan, Italy
  • Proteomics and Protein Structure Study Group,
    Division of Pharmacological Sciences, Department of Pharmacological
    and Biomolecular Sciences (DiSFeB), University of Milan, 20133
    Milano, Italy
  • Department of Food, Environmental
    and Nutritional Sciences (DeFENS), University of Milan,
    20133 Milan, Italy
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_ped-2015-0004
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