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2015 | 60 | 3 | 489-496
Tytuł artykułu

A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of this study is the evaluation of electron dose enhancement and photon contamination production by various nanoparticles in the electron mode of a medical linac. MCNPX Monte Carlo code was used for simulation of Siemens Primus linac as well as a phantom and a tumor loaded with nanoparticles. Electron dose enhancement by Au, Ag, I and Fe2O3 nanoparticles of 7, 18 and 30 mg/ml concentrations for 8, 12 and 14 MeV electrons was calculated. The increase in photon contamination due to the presence of the nanoparticles was evaluated as well. The above effects were evaluated for 500 keV and 10 keV energy cut-offs defined for electrons and photons. For 500 keV energy cut-off, there was no significant electron dose enhancement. However, for 10 keV energy cut-off, a maximum electron dose enhancement factor of 1.08 was observed for 30 mg/ml of gold nanoparticles with 8 MeV electrons. An increase in photon contamination due to nanoparticles was also observed which existed mainly inside the tumor. A maximum photon dose increase factor of 1.07 was observed inside the tumor with Au nanoparticles. Nanoparticles can be used for the enhancement of electron dose in the electron mode of a linac. Lower energy electron beams, and nanoparticles with higher atomic number, can be of greater benefit in this field. Photons originating from nanoparticles will increase the photon dose inside the tumor, and will be an additional advantage of the use of nanoparticles in radiotherapy with electron beams.
Wydawca

Czasopismo
Rocznik
Tom
60
Numer
3
Strony
489-496
Opis fizyczny
Daty
wydano
2015-07-01
otrzymano
2014-10-29
zaakceptowano
2015-06-11
online
2015-08-06
Twórcy
  • Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Medical Physics Department, Reza Radiation Oncology Center, Azadeh No. 1, Fallahi No. 2, Fallahi Ave., Ghasem Abad, Mashhad, Iran, Tel.: +98 51 3522 5673, Fax: +98 51 3522 5671
  • Medical Physics Department, Reza Radiation Oncology Center, Azadeh No. 1, Fallahi No. 2, Fallahi Ave., Ghasem Abad, Mashhad, Iran, Tel.: +98 51 3522 5673, Fax: +98 51 3522 5671, f.akbari1@gmail.com
  • Bioinformatics Research Center, Radiology and Radiotherapy Department, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Bibliografia
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  • 3. Cho, S. (2005). Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys. Med. Biol., 50(15), 163–173. DOI: 10.1088/0031-9155/50/15/N01.[Crossref]
  • 4. Zhang, S. X., Gao, J., & Buchholz, T. A. (2009). Quantifying tumour-selective radiation dose enhancements using gold nanoparticles: a Monte Carlo simulation study. Biomed. Microdevices, 11(4), 925–933. DOI: 10.1007/s10544-009-9309-5.[WoS][Crossref]
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  • 10. Jabari, N., & Hashemi, B. (2009). An assessment of the photon contamination due to bremsstrahlung radiation in the electron beams of a Neptun 10PC linac using a Monte Carlo method. Iran. J. Med. Phys., 6(1), 21–32.
  • 11. Mahdavi, M., Mahdavi, S. R. M., & Alijanzadeh, H. (2011). Comparing the measurement value of photon contamination absorbed dose in electron beam field for Varian clinical accelerator. IUP J. Phys., 5(3), 7–11.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_nuka-2015-0087
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