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Tytuł artykułu

ATP-binding peptide-hydrogel composite synthesized by molecular imprinting on beads

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Molecular imprinting has been recognized as a useful technique to produce synthetic mimics of functional proteins, such as antibodies and enzymes. However, only a few studies have examined peptides as starting materials for synthesizing molecularly imprinted polymers in spite of the expectation that peptides would be suitable materials for realizing water-compatibility and proteinlike functions. In this study, molecular imprinting was performed using a vinyl-end-capped on-beads-peptide as functional monomer to produce an on-beads-peptide hydrogel composite selective for ATP; the on-beadspeptide peptide, of which sequence was designed to possess both an adenine-recognition site and phosphate recognition site, was co-polymerized with NIPAM and BIS in the presence of ATP as a template species. The resultant ATP-imprinted composite showed 14-times higher affinity and an enhanced selectivity towards ATP, suggesting that the peptide conformation, i.e. a mutual orientation of the two binding sites, was pre-organized and immobilized in a manner where the ATP binding is more favored.
Słowa kluczowe
EN
peptide   hydrogel   ATP  
Wydawca

Rocznik
Tom
2
Numer
1
Opis fizyczny
Daty
otrzymano
2015-08-03
zaakceptowano
2015-12-28
online
2016-02-23
Twórcy
autor
  • Department of Nanobiochemistry, FIRST,
    Konan University, 7-1-20 Minatojima-minami-machi, Chuo-ku, Kobe
    650-0047, Japan
autor
  • Department of Nanobiochemistry, FIRST,
    Konan University, 7-1-20 Minatojima-minami-machi, Chuo-ku, Kobe
    650-0047, Japan
autor
  • Department of Nanobiochemistry, FIRST,
    Konan University, 7-1-20 Minatojima-minami-machi, Chuo-ku, Kobe
    650-0047, Japan
Bibliografia
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  • [2] Martín-Esteban A., Molecularly-imprinted polymers as aversatile, highly selective tool in sample preparation, TrACTrends in Analytical Chemistry, 2013, 45, 169-181.
  • [3] Sharma P.S., Iskierko Z., Pietrzyk-Le A., D’Souza F., KutnerW., Bioinspired intelligent molecularly imprinted polymersfor chemosensing: A mini review, Electrochemistry Communications,2015, 50, 81-87.[WoS]
  • [4] Tiwari M.P., Prasad A., Molecularly imprinted polymer basedenantioselective sensing devices: A review, Anal. Chim. Acta,2015, 853, 1–18.
  • [5] Wulff G., Liu J., Design of biomimetic catalysts by molecularimprinting in synthetic polymers: the role of transition statestabilization, Acc Chem Res., 2012, 45, 239-247.[WoS]
  • [6] Yoshimatsu K., Koide H., Hoshino Y., Shea K.J., Preparation ofAbiotic Polymer Nanoparticles for Sequestration and Neutralizationof a Target Peptide Toxin, Nature Prot., 2015, 10,595–604.
  • [7] Sellergren B., Molecularly imprinted polymers: man-mademimics of antibodies and their application in analyticalchemistry, Elsevier, 2000.
  • [8] Matsui J., Nagano J., Miyoshi D., Tamaki K., Sugimoto N., Anapproach to peptide-based ATP receptors by a combination ofrandom selection, rational design, and molecular imprinting,Biosens Bioelectron., 2009, 25, 563-567.[WoS]
  • [9] Matsui J., Kamitakahara Y., Nagano J., Ono Y., Komai S., MiyoshiD., Tamaki K., Sugimoto N., Molecular imprinting within asingle peptide molecule for synthesizing a water-soluble ATPreceptor, In: Ishida H., Peptide science 2006. Proceedings ofthe 43rd Japanese peptide symposium, Yokohama, November5-8, 2006, Japanese Peptide Society, 2006.
  • [10] Matsuurua, K., Rational design of self-assembled proteins andpeptides for nano- and micro-sized architectures, RSC Adv.,2014, 4, 2942-2953.
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  • [12] Shin D.S., Kim D.H., Chung W.J., Lee Y.S., Combinatorial solidphase peptide synthesis and bioassays, J. Biochem. Mol. Biol.2005, 38, 517-525.
  • [13] Matsui J., Akamatsu K., Nishiguchi S., Miyoshi D., NawafuneH., Tamaki K., Sugimoto N., Composite of Au nanoparticles andmolecularly imprinted polymer as a sensing material, Anal.Chem., 2004, 76, 1310.
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  • [15] Connors K.A., Binding constants: the measurement ofmolecular complex stability, Wiley-Interscience, 1987.
  • [16] Nakano S., Fukuda M., Tamura T., Sakaguchi R., Nakata E.,Morii T., Simultaneous Detection of ATP and GTP by CovalentlyLinked Fluorescent Ribonucleopeptide Sensors, J. Am. Chem.Soc., 2013, 135, 3465–3473.[WoS]
  • [17] Xu Z., Singh N.J., Lim J., Pan J., Kim H.N., Park S., Kim K.S., YoonJ., Unique sandwich stacking of pyrene-adenine-pyrene forselective and ratiometric fluorescent sensing of ATP at physiologicalpH, J. Am. Chem. Soc., 2009, 131, 15528–15533.
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  • [23] Hoshino Y., Ohashi R.C., Miura Y., Rational Design of SyntheticNanoparticles with a Large Reversible Shift of Acid DissociationConstants: Proton Imprinting in Stimuli Responsive NanogelParticles, Adv. Mater., 2014, 26. 3718-3723.[WoS]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_molim-2015-0008
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