Research on the treatment of Pseudomonas aeruginosa pneumonia in children by macrolide antibiotics

• Autorzy: Xu-qiang Huang , Li Deng , Gen Lu , Chun-hui He , Pei-qiong Wu , Zhi-wei Xie , Muhammad Aqeel Ashraf
• Języki publikacji: EN

Abstrakty

EN

To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases of children with Pseudomonas aeruginosa pneumonia were randomly divided into an observation group (n=30) and a control group (n=24). The observation group was treated with macrolide antibiotics and cefoperazone/sulbactam. The control group was treated with cefoperazone/ sulbactam during a course of 10-14 days. The total effective rate was 93.3% in the observation group, and 58.3% in the control group, and results in the observation group were superior to the control group notably (P>0.05). There were no significant differences in bacterial clearance rate, adverse reaction rate between two groups (P>0.05). The combined application of cefoperazone/sulbactam with macrolide antibiotics to treat Pseudomonas aeruginosa pneumonia in children would be a more effective clinical method.

Słowa kluczowe

EN

Pseudomonas Aeruginosa Pneumonia; Macrolide Antibiotics

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

wydano

2015-01-01

otrzymano

2015-07-10

zaakceptowano

2015-11-09

online

2015-12-17

Twórcy

autor

Xu-qiang Huang

• Department of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, 510120, China

autor

Li Deng

• Department of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, 510120, China,

autor

Gen Lu

• Department of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, 510120, China

autor

Chun-hui He

• Department of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, 510120, China

autor

Pei-qiong Wu

• Department of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, 510120, China

autor

Zhi-wei Xie

• Department of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, 510120, China

autor

Muhammad Aqeel Ashraf

• Faculty of Science & Natural Resources, Universiti Malaysia Sabah 88400 Kota Kinabalu Sabah Malaysia

Bibliografia

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• [3] Hongbing C., Chunjiang Z., Hui W., et al., The common pathogens resistance analysis of nosocomial infections in 13 teaching hospitals in china in 2011, Chinese Journal of Internal Medicine, 2013, 52(3), 203-212
• [4] Gaynes R., Edwards J.R., Overview of nosocomial infections caused by gram-negative bacilli, Clin. Infect. Dis., 2005, 41(6), 848-854[Crossref]
• [5] Demei Z., Fu W., Fupin H., et al., 2010 CHINET surveillance of bacterial resistance in China, Chinese Journal of Infection and Chemotherapy, 2011, 11(5), 321-329
• [6] Robert A., Bonomo R.A., Szabo D., Mechanisms of multidrug resistance in Acinetobacter Species and Pseudomonas aeruginosa, Clin. Infect. Dis., 2006, 43, (2), S49-56
• [7] Ning F.G., Zhao X.Z., Bian J., et al., Large-area burns with pandrug- resistant Pseudomonas aeruginosa infection and respiratory failure, Chin. Med. J. (Engl)., 2011, 124(3), 359-363
• [8] Chen X., Jin Y., Tang G., New pharmacology, Beijing, People’s Health Publishing House, 2011, 95-107
• [9] Li H., Li H.P., The mechanism study progress for the macrolide drug treatment of diffuse pan-bronchiolitis, Journal of Clinical Internal Medicine, 2011, 28(7), 500-502

Identyfikatory

DOI

10.1515/med-2015-0082