Study of the Correlation between the Level of CRP and Chemerin of Serum and the Occurrence and Development of DN

• Autorzy: Yunqian Wang , Min Wang , Baoping Chen , Jun Shi
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to find the correlation between CRP and chemerin in development of DN. We choose 90 type-2 diabetic patients between February 2010 and February 2013, who were then divided into DN group and healthy control group. The results of BP showed that there is no difference in SBP and DBP of patients in the three groups. HDL-C of patients in diabetic group and DN group is lower compared with control. CRP in diabetic group and DN group is higher than that of patients in control group. Comparing the patients in DN group with that in diabeteic group, CRP was significantly higher. Chemerin level in the diabetic group and DN group is higher than control group. When comparing the patients in DN group with those in diabeteic group, serum level of chemerin was significantly higher. Serum level of chemerin is negatively correlated with HDL-C and positively correlated with FPG, HbA1c, LDL-C, BUN and Scr. Serum CRP is negatively correlated with HDL-C and positively correlated with FPG, HbA1c, LDL-C, BUN and Scr. Serum level of chemerin is positively correlated with CRP (r=0.701, P<0.05). CRP and chemerin of the DN patients rose significantly, and may participate in the occurrence and development of DN.

Słowa kluczowe

EN

CRP; chemerin; DN

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

wydano

2015-01-01

otrzymano

2015-06-30

zaakceptowano

2015-10-15

online

2015-12-17

Twórcy

autor

Yunqian Wang

• University Huaihe Hospital, 475000, China,

autor

Min Wang

• Henan University Huaihe Hospital, 475000, China

autor

Baoping Chen

• Henan University Huaihe Hospital, 475000, China

autor

Jun Shi

• Henan University Huaihe Hospital, 475000, China

Bibliografia

• [1] Zeyu L., Dong L., Study of Diabetic Nephropathy (DN) Risk Factors and Blood Pressure Control Critical Value, J. Chinese General Practice, 2014,17(20), 2325-2328
• [2] Qin Z., Yaxin B., Study of the Correlation between Hypoxiainducible Factor 1αPro582Ser Gene Polymorphism and Type-2 Diabetic Nephropathy, J. The Journal of Practical Medicine, 2014, 30(13): 2078-2080.
• [3] Hui L., Yi Q., Yaoming X., et al., Relationship between Vascular Endothelial Growth Factor and Endostatin and Type-2 Diabetic Nephropathy, J. The Journal of Practical Medicine, 2014, 30(11), 1764-1767
• [4] Guoli C., Sheng L., Kuichen Z., et al., Diabetic Nephropathy Patients Quantity Variation of Serum FGF-2, TGF-βand CD4+, CD8+T Cells, J. Chinese Journal of Cellullar and Molecular Immunology, 2014, (2), 197-199
• [5] Xiaojuan F., Ping Z., Jin Y., et al., Variations and Meaning of Serum Level of 25-hydroxylation Vitamin D and CRP Diabetic Nephropathy Patients, J. Chinese Journal of Clinical Laboratory Science, 2013, 31(11), 838-840
• [6] Yanping L., Dayu C., Study of Diabetic Nephropathy CRP, T-lymphocytes Cell Subsets and D-dimer Expression, J. Modern Preventive Medicine, 2013, 40 (5), 929-930
• [7] WeinaY., Xuan W., Qian L., et al., Clinic Epidemiological Analysis of Type-2 Diabetes and Peripheral Artery Disease, J. Journal of Xi ‘an Jiaotong University: Medicine, 2013, 34 (1), 73-76
• [8] Chunlian C., Zhicheng W., Study of the Relationship between Chemerin, C - reactive Protein and 2-Diabetes Macroangiopathy, J. China Journal of Modern Medicine, 2013, (2), 61-64
• [9] Meiliu Y., Liping S., Variations of Serum Chemerin Level in the Diabetic Nephropathy, J. Modern Preventive Medicine, 2013, 40 (8), 1500-1501
• [10] Jing L., Study Progress of the Relationship between Chemerin and Glucolipid Metabolism, J. Chinese Journal of Clinical Pharmacology, 2012, 28 (1), 72-74
• [11] Ying Z., Qian W., Kaiping H., et al., Correlation between Type-2 Diabetic Patient Chemerin Level Changes and Lower Extremity Venous Disease, J. Journal of Shandong University: Medicine, 2011, 49(8), 9-12
• [12] Chunlian C., Yufang Y., Zhicheng W., Study of the Correlation between Serum Chemerin and C-reactive Protein Levels of Type-2 Diabetic Patients and Insulin-resistance and Macroangiopathy, J. Chinese General Practice, 2013, 16 (21), 2438-2440
• [13] Lan S., (Summary); Mechanisms of Chemerin in Obesity and Type-2 Diabetes, J. Journal of Medical Postgraduates, 2013, 26 (6), 646-649
• [14] Yu P., Variations and Clinic Meaning of Serum Chemerin and C-reactive Protein Level of Diabetic Nephropathy Patients, J. Chinese General Practice, 2013, 16 (6), 612-614
• [15] Liang S., Chaoming M., Long L., et al., Study on Serum Chemerin Level of Chronic Renal Failure Patients and Its Relationship with Renal Function, J. Chinese General Practice, 2012, 15 (36), 4166-4168
• [16] Lina P., Xiaojuan Z., Jian D., Effects of Metformin on the Insulin Resistance of Rat’s Visceral Adipose Tissues Chemerin Expression, J. Chinese Journal of Endocrinology and Metabolism, 2012,28 (9), 757-760

Identyfikatory

DOI

10.1515/med-2015-0080