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2014 | 10 | 1 |
Tytuł artykułu

Is cognitive processing affected in adults with hypospadias?: P300 study

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Background: Hypospadias is a common urogenital system disorder. The frenulum, which is the most sensitive area of the glans penis, is not present in patients with hypospadias. This may lead to a failure in sexual and ejaculatory function, and cause emotional problems affecting cognitive processes. Aim: We aimed to study auditory Event Related Potentials (ERP) in patients with hypospadias to understand the status of cognitive function. Materials and Methods: Seventeen patients with hypospadias who presented to the Urology Outpatient Clinic of Çanakkale Military Hospital, and 11 healthy individuals of similar age were chosen. The auditory oddball paradigm with ERP from the Cz and Fz head regions were studied. The latency and amplitude of the P300 wave were measured. Results: Both, the study and control groups consisted of young males. Although the study group had a longer P300 latency and lower P300 amplitude when compared to control group, the results were not statistically significant (p: 0.059 and 0.346 respectively). Conclusion: Although the results are not statistically significant, our findings indicate that there may be cognitive changes in patients with hypospadias. Further studies of larger sample size and older patient cohorts are needed.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2015-01-18
zaakceptowano
2015-09-14
online
2015-10-26
Twórcy
autor
  • GATA Haydarpaşa Eğitim Hastanesi, Department of
    Neurology, Istanbul, Turkey
  • Gölcük Asker Hastanesi, Department of Urology,
    Kocaeli, Turkey
autor
  • Çanakkale Onsekiz Mart Üniversitesi,
    Department of Urology, Çanakkale, Turkey
  • Okmeydani Education
    and Research Hospital Neurology Clinic Kaptanpasa Mahallesi
    Darülaceze Street No: 25 ZIP Code: 34384, Sisli, Istanbul, Turkey
  • Okmeydanı Eğitim Araştırma Hastanesi,
    Department of Neurology, İstanbul, Turkey
autor
  • Ankara Mevki Asker Hastanesi, Department of Neurology,
    Ankara, Turkey
  • GATA Haydarpaşa Eğitim Hastanesi, Department of
    Urology, Istanbul, Turkey
  • GATA Haydarpaşa Eğitim Hastanesi, Department of
    Neurology, Istanbul, Turkey
  • Çanakkale
    Onsekiz Mart Üniversitesi, Department of Neurology., Çanakkale,
    Turkey
  • Çanakkale Onsekiz Mart Üniversitesi,
    Department of Urology, Çanakkale, Turkey
  • Çanakkale
    Onsekiz Mart Üniversitesi, Department of Neurology., Çanakkale,
    Turkey
Bibliografia
  • [1] Dodds PR, Batter SJ, Shield DE, Serels SR, Garafalo FA, MaloneyPK. Adaptation of adults to uncorrected hypospadias; Urology2008; 71: 682-685[WoS][Crossref]
  • [2] Karademir K, Akyol İ, Adayener C. Effects of hypospadias onpsychosexual functions. Bulletin of Andrology 2006 December;p308–310 (Turkish)
  • [3] Hunt N, McHale S. Psychosocial aspects of andrologic disease.Endocrinol Metab Clin N Am 2007; 36:521–531
  • [4] Oken B. Endogenous event-related potentials, in Chiappa KH(Ed): Evoked Potentials in Clinical Medicine. Philadelphia,Lippincott-Raven, 1987, pp 529–563
  • [5] Goodin DS. Event related (endogenous) potentials. In: AminoffMJ editors. Electrodiagnosis in Clinical Neurology. New York:Churchill Livingstone; 1992; p. 627–648
  • [6] Picton, T. W. and Hillyard, S. A.: Endogenous event-relatedpotentials. In: Human Event-Related Potentials. EEG Handbook,revised series. Edited by T. W. Picton. New York: Elsevier, vol. 3,1989; p. 361
  • [7] Duncan CC, Barry RJ, Connolly JF, Fischer C, Michie PT, NäätänenR et al. Event-related potentials in clinical research: guidelinesfor eliciting, recording, and quantifying mismatch negativity,P300, and N400. Clin Neurophysiol. 2009; 120(11):1883-1908[WoS]
  • [8] Maria José Santos Cóser. P300 Auditory Evoked PotentialLatency In Elderly. Braz J Otorhinolaryngol 2010;76: 287-293
  • [9] Iacono WG, McGue M. Association between P3 event-relatedbrain potential amplitude and adolescent problem behavior.Psychophysiology. 2006; 43(5):465-469[Crossref]
  • [10] Vardi Y, Sprecher E, Gruenwald I, Yarnitsky D, Gartman I,Granovsky Y. The p300 event-related potential technique forlibido assessment in women with hypoactive sexual desiredisorder. J Sex Med 2009; 6: 1688–1695[WoS][Crossref]
  • [11] Vardi Y, Volos M, Sprecher E, Granovsky Y, Gruenwald I,Yarnitsky D. A p300 event related potential technique forassessment of sexually oriented interest. The Journal ofUrology 2006; 176; 2736–2740
  • [12] Knight RT. Electrophysiological methods in behavioralneurology and neurophysychology. In: Feinberg TE, Farah MJeditor. Behavioral Neurology and Neurophysychology. NewYork: McGraw Hill; 1997; p. 101–119
  • [13] Polich J, Herbst KL. P300 as a clinical assay (rationale,evaluation, and findings). Int J Psychophysiol. 2000; 38: 3–19[Crossref]
  • [14] Ozcan C, Ozbek E, Soylu A, Yilmaz U, Guzelipek M, Balbay DM.Auditory event-related potentials in patients with prematureejaculation. The Journal of Urology 2001; 58: 1025–1029
  • [15] Maretti MB, Haddad AS, Ferreira MC, Guaré Rde O, Alonso LG.Toriello Carey syndrome: genetic, clinical, and oral considerations:a case report. Spec Care Dentist. 2011 31: 68–72
  • [16] Golabi M, James AW, Good WV, Cotter PD. Tissue-limitedmosaicism for monosomy 13. Am J Med Genet A. 2010;152A(10): 2634–2639[WoS]
  • [17] Climent Alcalá FJ, Molina Rodríguez MA, González Casado I,Osona Bris L, Salamanca Fresno L, Guerrero-Fernández J, et al.Chromosome 9P deletion: Gonadal dysgenesis associated withmental retardation and hypoplasia of the corpus callosum: Acontiguous gene syndrome? An Pediatr (Barc). 2010 Mar;72:210–214
  • [18] Hoffman LD, Polich J. P300, handedness, and corpus callosalsize: gender, modality, and task. Int J Psychophysiol. 1999; 31:163–174[Crossref]
  • [19] Polich J, Hoffman LD. P300 and handedness: on the possiblecontribution of corpus callosal size to ERPs. Psychophysiology.1998; 35: 497–507
  • [20] Nager W, Krauss JK, Heldmann M, Marco-Pallares J, CapelleHH, Lütjens G et al. Human hypothalamus shows differentialresponses to basic motivational stimuli-an invasive electrophysiologystudy. Neuroscience. 2011 25;189:330–336[WoS]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0059
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