Efficacy of mistletoe for chemical pleurodesis in rats without malignancy

• Autorzy: Hyo Yeong Ahn , Jeong Su Cho , Yeong Dae Kim , Hoseok I , Yeon Ji Kim , Ahrong Kim , Chang Hun Lee
• Języki publikacji: EN

Abstrakty

EN

Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague- Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME.

Słowa kluczowe

EN

chemical pleurodesis; mistletoe extraction; animals

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

otrzymano

2015-02-09

zaakceptowano

2015-08-13

online

2015-09-04

Twórcy

autor

Hyo Yeong Ahn

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

autor

Jeong Su Cho

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

autor

Yeong Dae Kim

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

autor

Hoseok I

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

autor

Yeon Ji Kim

• Department of Thoracic and Cardiovascular Surgery,
  Pusan National University Yangsan Hospital, Yangsan, Republic of
  Korea

autor

Ahrong Kim

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

autor

Chang Hun Lee

• Department of Pathology, Pusan National
  University Hospital, Biomedical Research Institution, Busan,
  Republic of Korea

Bibliografia

• [1] Cho HJ, Na KJ, Kim do W, Choi YE, Ma JS, Jeong IS. Chemicalpleurodesis using a Viscum album extract in infants withcongenital chylothorax. Eur J Pediatr. 2014; 173: 823-826[WoS]
• [2] Zarogoulidis K, Zarogoulidis P, Darwiche K, et al. Malignantpleural effusion and algorithm management. J Thorac Dis.2013; 5: 413-419[WoS]
• [3] Suárez PM, Gilart JL. Pleurodesis in the treatment ofpneumothorax and pleural effusion. Monaldi Arch Chest Dis.2013; 79: 81-86
• [4] How CH, Tsai TM, Kuo SW, et al. Chemical pleurodesis forprolonged postoperative air leak in primary spontaneouspneumothorax. J Formos Med Assoc. 2014; 113: 284-290[WoS]
• [5] Agarwal R, Khan A, Aggarwal AN, Gupta D. Efficacy &safety of iodopovidone pleurodesis: a systematic review &meta-analysis. Indian J Med Res. 2012; 135: 297-304
• [6] Xia H, Wang XJ, Zhou Q, Shi HZ, Tong ZH. Efficacy andsafety of talc pleurodesis for malignant pleural effusion: ameta-analysis. PLoS One. 2014; 9: e87060
• [7] Kalomenidis I. Beyond talc pleurodesis: Do we really need newmethods?. Respirology 2011; 16: 1020-1022[Crossref][WoS]
• [8] Muta F, Takamori S, Matsuo T, Iwasaki Y, Yoshiyama K, ShirouzuK. Changes in the pleural cavity by pleurodesis using Talc orOK-432: An Experimental Study Surg Today. 2011; 41: 111-114[WoS]
• [9] Rossi VF, Vargas FS, Marchi E, et al. Acute inflammatoryresponse secondary to intrapleural administration of two typesof talc. Eur Respir J 2010; 35: 396-401[WoS]
• [10] Marchi E, Vargas FS, Teixeira LR, et al. Light Comparison ofnitrogen mustard, cytarabine and dacarbazine as pleuralsclerosing agents in rabbits. Eur Respir J 1997; 10: 598-602
• [11] Alper Gözübüyük, Berkant Özpolat, Ali Fuat Çiçek, et al.Comparison of side effects of oxytetracycline and talcpleurodesis: an experimental study. Journal of CardiothoracicSurgery. 2010; 5: 128[WoS][Crossref]
• [12] Georg Salzer. Pleural carcinosis. Cytomorphologicalfindings with the mistletoe preparation iscador and otherpharmaceuticas. Oncology. 1986;43:66-70
• [13] C. Stumpf, A. Bussing. Stimulation of antitumour immunityby intrapleural instillation of a viscum album L. extract.Anti-cancer Drugs.1997;8:23-26
• [14] Kim JJ, Lee SK, Im J, Choi H. Viscum Album therapy inmalignant pleural effusion. Korean J Thorac Cardiovasc Surg.2004;37:978-982
• [15] Margaret EL. Mistletoe. The Longwood Herbal Task Force andThe Center for Holistic Pediatric Education and Research. 1999http://www.longwoodherbal.org/mistletoe/mistletoe.pdf
• [16] Werebe EC, Pazetti R, Milanez de Campos JR, et al. Systemicdistribution of talc after intrapleural administration in rats.Chest. 1999; 115: 190-193[Crossref]
• [17] Fraticelli A, Robaglia-Schlupp A, Riera H, Monjanel-MouterdeS, Cau P, Astoul P. Distribution of calibrated talc afterintrapleural administration: an experimental study in rats.Chest. 2002; 122: 1737-1741
• [18] Janssen JP, Collier G, Astoul P, et al. Safety of pleurodesis withtalc poudrage in malignant pleural effusion: a prospectivecohort study. Lancet. 2007; 369: 1535-1539[WoS]
• [19] Gaafar R, Abdel Rahman AR, Aboulkasem F, El Bastawisy A.Mistletoe preparation (Viscum Fraxini-2) as palliative treatmentfor malignant pleural effusion: a feasibility study withcomparison to bleomycin. Ecancermedicalscience. 2014; 8: 424
• [20] Stan RL, Hangan AC, Dican L, et al. Comparative studyconcerning mistletoe viscotoxins antitumor activity. Acta BiolHung. 2013; 64: 279-288[WoS]

Identyfikatory

DOI

10.1515/med-2015-0051