Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
Ple iotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). Following the cytokine blockade as a successful clinical therapy for autoimm une diseases such as rheumatoid arthritis, the patients are more susceptible to a variety of opportunistic infections. IL-1 and TNF-α may be useful predictive biomarkers of diseases and offer potential targets for therapeutic intervention of inflammatory diseases. However, our results showed that the plasma IL-1 level was significantly higher in women compared to men (69.5 ± 19.8 pg/ ml in men and 80.1 ± 19.5 pg/ml in women, respectively); the plasma levels of TNF-α were higher in men than women (20.8 ± 4.9 pg/ml and 18.7 ± 7.1 pg/ml, respectively). The significant gender difference of plasma interleukin-1 (IL-1) and TNF-α levels present in healthy adults in Jiangsu Province, China (P=0.002 and P=0.015, respectively), and may be as a hint for sex differences of susceptibility to many diseases and elementary immune response.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Numer
Opis fizyczny
Daty
otrzymano
2014-05-04
zaakceptowano
2015-05-13
online
2015-06-09
Twórcy
autor
- Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
- Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
autor
- Danyang Blood Center of Jiangsu Province, Danyang, Jiangsu 212300, China
autor
- Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
- Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
autor
- Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
- Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
autor
- Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
- Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
Bibliografia
- [1] Stanley AC, Lacy P. Pathways for cytokine secretion. Physiology2010; 25:218-229[WoS][Crossref]
- [2] Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest 2000;117:1162-1172
- [3] Dinarello CA. Biologic basis for interleukin-1 in disease. Blood1996; 87:2095-2147
- [4] Tocci MJ. Structure and function of interleukin-1 beta convertingenzyme. Vitamins and hormones 1997; 53:27-63[Crossref]
- [5] Rachal Pugh C, Fleshner M, Watkins LR, Maier SF, Rudy JW.The immune system and memory consolidation: a role for thecytokine IL-1beta. Neuroscience and biobehavioral reviews2001; 25:29-41
- [6] Shieh JH, Peterson RH, Moore MA. IL-1 modulation of cytokinereceptors on bone marrow cells. In vitro and in vivo studies.Journal of immunology 1991; 147:1273-1278
- [7] Dinarello CA, Wolff SM. The role of interleukin-1 in disease. TheNew England journal of medicine 1993; 328:106-113
- [8] Dinarello CA. The interleukin-1 family: 10 years of discovery.FASEB journal : official publication of the Federation ofAmerican Societies for Experimental Biology 1994; 8:1314-1325
- [9] Hannum CH, Wilcox CJ, Arend WP, Joslin FG, Dripps DJ, HeimdalPL, et al. Interleukin-1 receptor antagonist activity of a humaninterleukin-1 inhibitor. Nature 1990; 343:336-340
- [10] Arend WP. Interleukin 1 receptor antagonist. A new memberof the interleukin 1 family. The Journal of clinical investigation1991; 88:1445-1451
- [11] Dinarello CA, Thompson RC. Blocking IL-1: interleukin 1receptor antagonist in vivo and in vitro. Immunology today1991; 12:404-410
- [12] Eisenberg SP, Brewer MT, Verderber E, Heimdal P, BrandhuberBJ, Thompson RC. Interleukin 1 receptor antagonist is a memberof the interleukin 1 gene family: evolution of a cytokine controlmechanism. Proceedings of the National Academy of Sciencesof the United States of America 1991; 88:5232-5236
- [13] Beutler B, Cerami A. Cachectin: more than a tumor necrosisfactor. The New England journal of medicine 1987; 316:379-385
- [14] Dayer JM, Beutler B, Cerami A. Cachectin/tumor necrosis factorstimulates collagenase and prostaglandin E2 production byhuman synovial cells and dermal fibroblasts. The Journal ofexperimental medicine 1985; 162:2163-2168
- [15] Vlassara H, Brownlee M, Manogue KR, Dinarello CA, PasagianA. Cachectin/TNF and IL-1 induced by glucose-modifiedproteins: role in normal tissue remodeling. Science 1988;240:1546-1548
- [16] Ettehadi P, Greaves MW, Wallach D, Aderka D, Camp RD.Elevated tumour necrosis factor-alpha (TNF-alpha) biologicalactivity in psoriatic skin lesions. Clinical and experimentalimmunology 1994; 96:146-151
- [17] Krueger G, Callis K. Potential of tumor necrosis factor inhibitorsin psoriasis and psoriatic arthritis. Archives of dermatology2004; 140:218-225
- [18] Cohen J. The immunopathogenesis of sepsis. Nature 2002;420:885-891
- [19] Goodman RB, Pugin J, Lee JS, Matthay MA. Cytokine-mediatedinflammation in acute lung injury. Cytokine & growth factorreviews 2003; 14:523-535
- [20] Park WY, Goodman RB, Steinberg KP, Ruzinski JT, Radella F,2nd, Park DR, et al. Cytokine balance in the lungs of patientswith acute respiratory distress syndrome. American journal ofrespiratory and critical care medicine 2001; 164:1896-1903
- [21] Tyburski JG, Dente C, Wilson RF, Steffes C, Devlin J, Carlin AM,et al. Differences in arterial and mixed venous IL-6 levels: thelungs as a source of cytokine storm in sepsis. Surgery 2001;130:748-51; discussion 751-752
- [22] Hollenberg SM, Cunnion RE, Parrillo JE. The effect of tumornecrosis factor on vascular smooth muscle. In vitro studiesusing rat aortic rings. Chest 1991; 100:1133-1137
- [23] Desai TR, Leeper NJ, Hynes KL, Gewertz BL. Interleukin-6causes endothelial barrier dysfunction via the protein kinase Cpathway. The Journal of surgical research 2002; 104:118-123
- [24] Sedgwick JB, Menon I, Gern JE, Busse WW. Effects ofinflammatory cytokines on the permeability of human lungmicrovascular endothelial cell monolayers and differentialeosinophil transmigration. The Journal of allergy and clinicalimmunology 2002; 110:752-756
- [25] Maruo N, Morita I, Shirao M, Murota S. IL-6 increasesendothelial permeability in vitro. Endocrinology 1992;131:710-714
- [26] Plackett TP, Gamelli RL, Kovacs EJ. Gender-based differences incytokine production after burn injury: a role of interleukin-6.Journal of the American College of Surgeons 2010; 210:73-78
- [27] Sinha I, Cho BS, Roelofs KJ, Stanley JC, Henke PK, UpchurchGR, Jr. Female gender attenuates cytokine and chemokineexpression and leukocyte recruitment in experimental rodentabdominal aortic aneurysms. Annals of the New York Academyof Sciences 2006; 1085:367-379
- [28] Imahara SD, Jelacic S, Junker CE, O’Keefe GE. The influence ofgender on human innate immunity. Surgery 2005; 138:275-282
- [29] Aulock SV, Deininger S, Draing C, Gueinzius K, Dehus O,Hermann C. Gender difference in cytokine secretion on immunestimulation with LPS and LTA. Journal of interferon & cytokineresearch : the official journal of the International Society forInterferon and Cytokine Research 2006; 26:887-892
- [30] Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM,Chaudry IH. Females in proestrus state maintain splenicimmune functions and tolerate sepsis better than males.Critical care medicine 1997; 25:106-110
- [31] Wichmann MW, Muller C, Hornung HM, Lau-Werner U,Schildberg FW, Colorectal Cancer Study G. Gender differencesin long-term survival of patients with colorectal cancer. TheBritish journal of surgery 2001; 88:1092-1098
- [32] Baynam G, Khoo SK, Rowe J, Zhang G, Laing I, Hayden C, etal. Parental smoking impairs vaccine responses in childrenwith atopic genotypes. The Journal of allergy and clinicalimmunology 2007; 119:366-374
- [33] Wiertsema SP, Khoo SK, Baynam G, Veenhoven RH, Laing IA,Zielhuis GA, et al. Association of CD14 promoter polymorphismwith otitis media and pneumococcal vaccine responses. Clinicaland vaccine immunology : CVI 2006; 13:892-897
- [34] Prather AA, Carroll JE, Fury JM, McDade KK, Ross D, MarslandAL. Gender differences in stimulated cytokine productionfollowing acute psychological stress. Brain, behavior, andimmunity 2009; 23:622-628[Crossref]
- [35] Villacres MC, Longmate J, Auge C, Diamond DJ. Predominanttype 1 CMV-specific memory T-helper response in humans:evidence for gender differences in cytokine secretion. Humanimmunology 2004; 65:476-485
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0044