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2014 | 10 | 1 |
Tytuł artykułu

Differences of plasma IL-1 and TNF-α in healthy Chinese Population

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Ple iotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). Following the cytokine blockade as a successful clinical therapy for autoimm une diseases such as rheumatoid arthritis, the patients are more susceptible to a variety of opportunistic infections. IL-1 and TNF-α may be useful predictive biomarkers of diseases and offer potential targets for therapeutic intervention of inflammatory diseases. However, our results showed that the plasma IL-1 level was significantly higher in women compared to men (69.5 ± 19.8 pg/ ml in men and 80.1 ± 19.5 pg/ml in women, respectively); the plasma levels of TNF-α were higher in men than women (20.8 ± 4.9 pg/ml and 18.7 ± 7.1 pg/ml, respectively). The significant gender difference of plasma interleukin-1 (IL-1) and TNF-α levels present in healthy adults in Jiangsu Province, China (P=0.002 and P=0.015, respectively), and may be as a hint for sex differences of susceptibility to many diseases and elementary immune response.
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2014-05-04
zaakceptowano
2015-05-13
online
2015-06-09
Twórcy
autor
  • Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
  • Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
autor
  • Danyang Blood Center of Jiangsu Province, Danyang, Jiangsu 212300, China
autor
  • Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
  • Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
  • Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
  • Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
autor
  • Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
  • Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0044
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