Differences of plasma IL-1 and TNF-α in healthy Chinese Population

• Autorzy: Jintao Yuan , Lan Wang , Yijin Lin , Jianhong Chen , Jianghong Hu
• Języki publikacji: EN

Abstrakty

EN

Ple iotropic proinflammatory cytokines, interleukin- 1 (IL-1) and tumor necrosis factor-α (TNF-α), involved in the regulations of various immune responses, inflammatory processes and hematopoiesis. In the present study, the expression levels of IL-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA). Following the cytokine blockade as a successful clinical therapy for autoimm une diseases such as rheumatoid arthritis, the patients are more susceptible to a variety of opportunistic infections. IL-1 and TNF-α may be useful predictive biomarkers of diseases and offer potential targets for therapeutic intervention of inflammatory diseases. However, our results showed that the plasma IL-1 level was significantly higher in women compared to men (69.5 ± 19.8 pg/ ml in men and 80.1 ± 19.5 pg/ml in women, respectively); the plasma levels of TNF-α were higher in men than women (20.8 ± 4.9 pg/ml and 18.7 ± 7.1 pg/ml, respectively). The significant gender difference of plasma interleukin-1 (IL-1) and TNF-α levels present in healthy adults in Jiangsu Province, China (P=0.002 and P=0.015, respectively), and may be as a hint for sex differences of susceptibility to many diseases and elementary immune response.

Słowa kluczowe

EN

Proinflammatory cytokine; IL-1; TNF-α; genderdifference

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

otrzymano

2014-05-04

zaakceptowano

2015-05-13

online

2015-06-09

Twórcy

autor

Jintao Yuan

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

autor

Lan Wang

• Danyang Blood Center of Jiangsu Province, Danyang, Jiangsu 212300, China

autor

Yijin Lin

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

autor

Jianhong Chen

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

autor

Jianghong Hu

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

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Identyfikatory

DOI

10.1515/med-2015-0044