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2014 | 10 | 1 |
Tytuł artykułu

Profile of adult acute cholinesterase inhibitors substances poisoning – a 30 years analysis

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Objectives: The objective of this study was to assess the pattern and outcome of acute cholinesterase inhibitors substances (CIS) poisoning cases, in a cohort from a regional tertiary care hospital. Methods: cases admitted in the Toxicology Clinic of “Sf. Spiridon” Emergency Clinic Hospital Iasi, Romania between 1983 and 2013 were studied. Results: a total number of 606 patients were included. The reason for exposures was intentional in 70% of cases and the commonest route of poisoning was oral in 92.2%. The highest percent of cases was females (56.4), the age group 20-29 (25.4%) and the majority (66.7%) coming from rural areas, 28.2% being agricultural workers. 36.6% of cases were severe clinical forms. Overall mortality rates were 3.8%, more than half of the death patients (65.2%) had concomitant alcohol intake. It was a significant statistical association between decrease level of serum cholinesterase on admittance and severe forms (p 0.000) and between survival and deaths groups (p 0.000). The pattern of poisoning described by our retrospective study suggests that CIS poisoning are mainly preventable. The main effective goals for prevention are restriction in free accessibility to toxic pesticides, together with sustained efforts in education concerning the life-threatening danger of pesticide poisoning.
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2014-09-18
zaakceptowano
2015-03-31
online
2015-05-08
Twórcy
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • Pharmacology – Toxicology Department,
    Faculty of Medicine, „Gr. T. Popa” University of Medicine
    and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • Pharmacology – Toxicology Department,
    Faculty of Medicine, „Gr. T. Popa” University of Medicine
    and Pharmacy, Iasi, Romania
  • Physiopathology Department, Faculty of Medicine,
    „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
Bibliografia
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  • [4] Eddleston M, Sudarshan K, Senthilkumaran M, Reginald K,Karalliedde L, Senarathna L, de Silva D, Rezvi Sheriff MH,Buckley NA, Gunnell DJ. Patterns of hospital transfer forself-poisoned patients in rural Sri Lanka: implications forestimating the incidence of self-poisoning in the developingworld. Bull World Health Organ 2006; 84: 276-282[Crossref]
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  • [19] Banerjee I, SK Tripathi, Roy AS. Clinico-EpidemiologicalCharacteristics of Patients Presenting with OrganophosphorusPoisoning. N Am J Med Sci. 2012; 4(3): 147-150[Crossref]
  • [20] Rehiman S, Lohani SP, Bhattarai MC. Correlation of serumcholinesterase level, clinical score at presentation and severityof organophosphorous poisoning. J Nepal Med Assoc.2008;47:47-52
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  • [22] Sorodoc V, Jaba IM, Lionte C, Mungiu OC, Sorodoc L.Epidemiology of acute drug poisoning in a tertiary center fromIași county, Romania. Hum Exp Toxicol 2011; 30(12):1896-1903[Crossref]
  • [23] Eddleston M, Buckley NA, Konradsen F. Identification ofstrategies to prevent death after pesticide self-poisoning usingHaddon matrix. Inj Prev 2006; 12(5):333-337[Crossref]
  • [24] Risal A, Sharma PP, Karkib R. Psychiatric Illnesses among thePatients Admitted for Self-poisoning in a Tertiary Care Hospitalof Nepal. Journal of Advances in Internal Medicine 2013;02(01):10-3
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  • [27] Eddleston M, Eyer P, Worek F, Sheriff M, Buckley NA. Predictingoutcome using butyrylcholinesterase activity in organophosphoruspesticide self poisoning. QJM 2008; 101:467-474[WoS][Crossref]
  • [28] Li Y, Tse ML, Gawarammana I, Buckley N, Eddleston M.Systematic review of controlled clinical trials of gastric lavagein acute organophosphorus pesticide poisoning. Clin Toxicol(Phila) 2009; 47:179-192[WoS][Crossref]
  • [29] Eddleston M, Haggalla S, Reginald K, Sudarshan K, SenthilkumaranM, Karalliedde L, Ariaratnam A, Sheriff MHR, WarrellDA, Buckley NA. The hazards of gastric lavage for intentionalself-poisoning in a resource poor location. Clinical Toxicology2007; 45:136-143[WoS][Crossref]
  • [30] Naderi S, Sud P, Acerra J, Pardo S, D Amore JZ, Ward MF,Mathias M, Miele K, Bose RA, Alagappan K. The Use of GastricLavage in India for Poisoned Patients. J Clin Toxicol 2012; 2:118[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0041
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