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2014 | 10 | 1 |
Tytuł artykułu

Carotid ultrasound for pulmonary arteriovenous malformation screening

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Języki publikacji
EN
Abstrakty
EN
Objective: In patients with hereditary hemorrhagic telangiectasia (HHT), pulmonary arteriovenous malformations (PAVMs) can cause serious neurological complications. Our aim was to evaluate the potential of contrast-enhanced Doppler ultrasound (CE-US) of the common carotid artery as a screening test for detection of PAVMs. Methods: A total of 124 consecutive patients with HHT or a positive family history underwent screening for PAVMs with CE-US and thoracic contrast-enhanced magnetic resonance angiography (CE-MRA). CE-US was performed after receiving (D)-galactose microparticulate, and CE-MRA with gadobenate dimeglumine. Twenty-five patients with confirmed PAVMs were referred to conventional pulmonary catheter angiography (PA). Findings on CE-US and CE-MRA were evaluated using contingency tables and McNemar’s test. Results: Using CE-MRA as the reference test, CE-US had a sensitivity of 100%, a specificity of 87%, and a negative predictive value of 100%. In 25 patients who underwent PA, PAVMs that had been diagnosed on CE-US and CE-MRA were confirmed. Of the PAVMs detected by CE-MRA, 24% were not identified on PA. Conclusion: CE-US is a simple, minimally invasive screening method that can easily be performed in different settings. CE-US can predict PAVMs with high probability of success. CE-US may be a simple alternative to transthoracic echocardiography in the assessment of PAVMs in certain HHT-patients.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2014-12-19
zaakceptowano
2015-04-04
online
2015-05-11
Twórcy
  • Department of Cardiology,
    Städtisches Krankenhaus Pirmasens gGmbH, Pettenkoferstr.
    22, 66955 Pirmasens, Germany
  • Medical Faculty of the Saarland University,
    66421 Homburg/Saar, Germany
  • Department of Diagnostic and Interventional
    Radiology, Saarland University Hospital, 66421 Homburg/Saar,
    Germany
  • Department of Diagnostic and Interventional
    Radiology, Saarland University Hospital, 66421 Homburg/Saar,
    Germany
  • Department of Medical Biometry, Epidemiology and
    Medical Informatics, Saarland University Hospital, 66421 Homburg/
    Saar, Germany
  • Department of Otorhinolaryngology, Essen
    University Hospital, 45147 Essen, Germany
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0040
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