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Czasopismo
2014 | 10 | 1 |
Tytuł artykułu

Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with rheumatoid arthritis

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Objectives: It has been well documented that the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) are associated with outcomes for patients with gastric cancer, non-small cell lung cancer and acute heart failure. Inflammation may be the hidden factor that explains the correlation between NLP, PLR, and these diseases. However, to date, the data concerning NLR, PLR, and its association with inflammation are lacking in patients with rheumatoid arthritis (RA), thus, our aim to discuss whether NLR and PLR are associated with RA. Methods: Patients with RA and healthy individuals were included according to the determined criteria, and laboratory indicators were measured. Results: PLR and NLR were significantly higher in RA patients compared with healthy controls (3.20±2.06 vs. 1.56±0.47, P<0.01; 192.85±101.78 vs. 103.49±28.68, P<0.01). When leukocytes, neutrophil percentage, neutrophil, lymphocyte, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) were considered as confounders (crude model), our results indicated that ESR and RF were correlated to RA. Of note, ESR, RF, and PLR were associated with RA after further adjustment based on crude model for PLR and NLR. Receiver operating characteristic (ROC) curves analysis showed that PLR values higher than >115.7 evaluated RA with a sensitivity of 82.5%, a specificity of 74.8% and area under the curve ( AUC ) of 0.847. Conclusions:Our results suggest that PLR is associated with RA, and PLR may be an underlying indicator indicating the chronic subclinical inflammation in patients with RA.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
zaakceptowano
2014-03-13
otrzymano
2014-11-27
online
2015-04-14
Twórcy
autor
  • Laboratory Medicine Diagnostic Centre, The
    First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
    China
autor
  • Laboratory Medicine Diagnostic Centre, The
    First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
    China
autor
  • Laboratory Medicine Diagnostic Centre, The
    First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
    China
  • Laboratory Medicine Diagnostic Centre, The
    First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
    China
autor
  • Department of Rheumatology, The First Affiliated Hospital,
    Xin Jiang Medical University
autor
  • Laboratory Medicine Diagnostic Centre, The
    First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
    China
autor
  • The First Affiliated Hospital,
    Xin Jiang Medical University, No.1-137, Liyushan Road, Xin’shi Region,
    Urumqi.XinJiang, China 830011
Bibliografia
  • [1] Scott D.L., Wolfe F., Huizinga T.W., Rheumatoid arthritis,Lancet., 2010,376,1094-1108
  • [2] Firestein G.S., Evolving concepts of rheumatoid arthritis,Nature.,2003,423, 356-361
  • [3] Felson D.T., Anderson J.J., Boers M., Bombardier C., ChernoffM., Fried B., The American College of Rheumatology preliminarycore set of disease activity measures for rheumatoid arthritisclinical trials, Arthritis Rheum., 1993,36,729-740
  • [4] Arruda-Olson A.M., Reeder G.S., Bell MR., Weston S.A.,Roger V.L., Neutrophilia predicts death and heart failureafter myocardial infarction: A community-based study, CircCardiovasc Qual Outcomes., 2009,2, 656-662
  • [5] Rudiger A., Burckhardt O.A., Harpes P., Muller S.A., FollathF., The relative lymphocyte count on hospital admission is arisk factor for long-term mortality in patients with acute heartfailure, Am J Emerg Med., 2006, 24, 451-454
  • [6] Tamhane U.U., Aneja S., Montgomery D., Rogers E.K., EagleK.A., Gurm H.S., Association between admission neutrophil tolymphocyte ratio and outcomes in patients with acute coronarysyndrome, Am J Cardiol., 2008,102,653-657[WoS]
  • [7] Nunez J., Nunez E., Bodi V., et al., Usefulness of the neutrophilto lymphocyte ratio in predicting long-term mortality in STsegment elevation myocardial infarction, Am J Cardiol.,2008,101,747-752.[WoS]
  • [8] Walsh S.R., Cook E.J., Goulder F., Justin T.A., Keeling N.J.,Neutrophil-lymphocyte ratio as a prognostic factor in colorectalcancer, J Surg Oncol .,2005,91,181-184
  • [9] Kaplan Z.S., Jackson S.P., The role of platelets inatherothrombosis, Hematology Am Soc Hematol EducProgram., 2011, 46, 51-61
  • [10] Huo Y., Ley K.F., Role of platelets in the development of atherosclerosis,Trends Cardiovasc Med., 2004,14,18-22[Crossref]
  • [11] İsmail Boyraz., Bünyamin Koç., Ahmet Boyacı., AhmetTutoğlu., Hakan Sarman., Hilal Özkan., Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosingspondylitis that are treating with anti-TNF, Int J Clin Exp Med.,2014,7,2912-2915
  • [12] Unal D., Eroglu C., Kurtul N., Oguz A., Tasdemir A., Areneutrophil/lymphocyte and platelet/lymphocyte rates inpatients with non-small cell lung cancer associated withtreatment response and prognosis? Asian Pac J Cancer Prev.,2013,14, 5237-5242
  • [13] Akkaya E., Gul M., Ugur M., Platelet to lymphocyte ratio: Asimple and valuable prognostic marker for acute coronarysyndrome., Int J Cardiol 28:13-15, 2014[WoS]
  • [14] Arnett F.C., Edworthy S.M., Bloch D.A., McShane D.J., FriesJ.F., Cooper NS., The American Rheumatism Association 1987revised criteria for the classification of rheumatoid arthritis,Arthritis Rheum., 1988, 31,315-324
  • [15] Stenvinkel P., Malnutrition and chronic inflmmation as riskfactors for cardiovascular disease in chronic renal failure,Blood Purif., 2001, 19,143-151[Crossref]
  • [16] Koyama H., Maeno T., Fukumoto S., et al., Platelet P-selectinexpression is associated with atherosclerotic wall thickness incarotid artery in humans, Circulation., 2003,108,524-529
  • [17] Borissoff J.I., Spronk H.M., Cate H., The hemostaticsystem as a modulator of atherosclerosis, N Engl J Med.,2013,364,1746-1760
  • [18] Turkmen K., Erdur F.M., Ozcicek F., et al., Platelet-to-lymphocyteratio better predicts inflmmation than neutrophil-tolymphocyteratio in end-stage renal disease patients, HemodialInt., 2013, 17, 391-396[Crossref]
  • [19] Klinger M.H., Jelkmann W., Role of blood platelets in infectionand inflammation, J Interferon Cytokine Res.,2002, 22,913-922
  • [20] Sierko E., Wojtukiewicz M.Z., Inhibition of platelet function:does it offer a chance of better cancer progression control?Seminars in thrombosis and hemostasis., 2007, 33,712-721
  • [21] Kushner I., C-reactive protein in rheumatology, ArthritisRheum., 1991, 35, 982-984
  • [22] Wolfe F., Comparative usefulness of C-reactive protein anderythrocyte sedimentation rate in patients with rheumatoidarthritis, J Rheumatol., 1997, 24, 1477-1485
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0037
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