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2014 | 10 | 1 |
Tytuł artykułu

The association between red blood cell distribution width and acute pancreatitis associated lung injury in patients with acute pancreatitis

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
B ackground: Red blood cell distribution width (RDW) that describes red blood cell volume heterogeneity is a common laboratory test. Our aim was to focus on th e association between RDW and a c ute pancreatitis associated lung injury (APALI). Methodology: A total of 152 acute pancreatitis (AP) patients who conformed to the criteria w ere included in this study. The demographic data, medical histories and laboratory measures was obtained from each patient on admission, further, the medical histories and biological data were analyzed, retrospectively. Results: Increased RDW at admission was observed in patients with APALI compared with the non-APALI groups. Our results exhibited that RDW was an independent risk factor for APALI after adjusting leukocyte, neutrophil percentage, random blood glucose (RBG), total bilirubin (TB) and total bile acid(TBA)(Crude model) (OR=2.671;CI 95% 1.145-6.230; P=0.023), further adjustment based on Crude model for sex and age did not attenuate the significantly high risk of APALI in patients with AP, RWD still remained a ro les as an independent risk factor for APALI (OR=2.653;CI95 % 1.123-6.138; P=0.026). Conclusions: Our study demonstrate that RDW at admission is associated with APALI and should be considered as an underlying risk factor of APALI.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2014-10-30
zaakceptowano
2015-01-15
online
2015-02-10
Twórcy
autor
  • Laboratory Medicine
    Diagnostic Centre,The First Affiliated Hospital, Xin Jiang Medical University,
    No.1-137, Liyushan Road, Xin’shi Region, Urumqi. XinJiang,
    China
  • Laboratory Medicine
    Diagnostic Centre,The First Affiliated Hospital, Xin Jiang Medical University,
    No.1-137, Liyushan Road, Xin’shi Region, Urumqi. XinJiang,
    China
autor
  • Hemopathy Research Center, The First Affiliated Hospital,
    Xin Jiang Medical University, Xinjiang Urumqi, China
autor
  • Laboratory Medicine
    Diagnostic Centre,The First Affiliated Hospital, Xin Jiang Medical University,
    No.1-137, Liyushan Road, Xin’shi Region, Urumqi. XinJiang,
    China
  • Department of Gastroenterology, The First Affiliated
    Hospital of Xinjiang Medical University, Xinjiang Urumqi, China
autor
  • Laboratory Medicine
    Diagnostic Centre,The First Affiliated Hospital, Xin Jiang Medical University,
    No.1-137, Liyushan Road, Xin’shi Region, Urumqi. XinJiang,
    China
Bibliografia
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  • [2] Huo TI., Wu JC., Lin HC., et al., Evaluation of the increase inmodel for end-stage liver disease (DMELD) score over time asa prognostic predictor in patients with advanced cirrhosis:risk factor analysis and comparison with initial MELD andChild-Turcotte-Pugh score, J Hepatol., 2005, 42, 826-832[Crossref]
  • [3] Öztürk Z.A., Ünal A., Yigiter R.Y., et al., Is increased red celldistribution width (RDW) indicating the inflammation inAlzheimer’s disease (AD)? Arch Gerontol Geriatr., 2013, 56,50-54
  • [4] Ani C., Ovbiagele B., Elevated red blood cell distribution widthpredicts mortality in persons with known stroke, J Neurol Sci,2009, 277, 103-108[WoS]
  • [5] Felker G.M., Allen L.A., Pocock S., Shaw L.K., McMurray J.J.,Pfeffer M.A., Red cell distribution width as a novel prognosticmarker in heart failure:Data from the CHARM Program and theDuke Databank, J Am Coll Cardiol., 2007, 50, 40-47[Crossref]
  • [6] Hampole C.V., Mehrotra A.K., Thenappan T., Gomberg-MaitlandM., Shah S.J., Usefulness of red cell distribution width as aprognostic marker in pulmonary hypertension, Am J Cardiol.,2009,104,868-872[WoS][Crossref]
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  • [9] YesSil A., Senates E., Bayog˘lu I.V., Erdem E.D., DemirtunçR., Kurdaş Övünç AO., Red cell distribution width: A novelmarker of activity in inflammatory bowel disease, Gut., 2011, 5,460-467[Crossref][WoS]
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  • [11] Kolber W., Sporek M., Dumnicka P., et al., Acute pancreatitisand red cell distribution width (RDW)at early phase of disease,Przegl Lek., 2013,11, 916-919
  • [12] China medical association., Chinese guide of diagnosis andtreatment of acute pancreatitis (2013,Shanghai), Chin J Dig.,2013, 33, 217-222
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  • [15] Gulla A., Evans B.J., Navenot J.M., et al., Heme Oxygenase-1GenePromoter Polymorphism is Associated With theDevelopment of Necrotizing Acute Pancreatitis, Pancreas .,2014,16,125-131
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  • [19] Zhao X.H., Zhao Z.S., Xu G.M., Lung injury of the pathogenesisof acute pancreatitis complicated multiple organ dysfunction,Chin J Muh Organ Dis Elderly., 2003, 2, 70-73
  • [20] Hoyos S., Granell S., Heredia N., Bulbena O., Closa D.,Fernández-Cruz L., Influence of portal blood on thedevelopment of systemic inflammationass&-ciatedwithexperimental acute pancreatitis, Surgery., 2005, 137, 186-191
  • [21] Escobar J., Pereda J., Lopez-Rodas G., Sastre J., Redox signalingand histone acetylation in acute pancreatitis, Free Radic BiolMed., 2012, 52, 819-827
  • [22] Escobar J., Pereda J., Arduini A., et al., Cross-talk betweenoxidative stress and pro-inflammatory cytokines in acutepancreatitis: a key role for protein phosphatases, Curr PharmDes., 2009, 15, 3027-3042[Crossref]
  • [23] Ku N.S., Kim H.W., Oh H.J., et al., Red blood cell distributionwidth is an independent predictor of mortalityin patients withgram negative bacteremia, Shock 2012, 38, 123-127[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0028
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