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2014 | 10 | 1 |
Tytuł artykułu

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Background: In some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy). Methods: 36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apoli- poproteins A-I, B, and hsCRP immunoturbidimetrically. Results: The postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-choles- terol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy. Conclusion: In men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2013-10-20
zaakceptowano
2014-03-31
online
2015-02-03
Twórcy
  • Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0025
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