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2014 | 10 | 1 |
Tytuł artykułu

Trefoil factor 3 as a marker of intestinal cell damage during sepsis

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Objective: Gastrointestinal dysfunction or gut failure frequently occurs in seriously ill patients and can be responsible for multi-organ failure. Trefoil factor 3 (TFF3) was characterized for its role in reconstitution of an epithelial barrier after mucosal injury in the jejunum. The aims of our study was an analysis of TFF3 levels dynamics in patients with sepsis and the correlation of TFF3 with severity of sepsis and mortality. Methods: Prospective observational study, a ten days evaluation period in children aged 0-19 years with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of TFF3 were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis. Results: Analysis of dynamics revealed steady levels of TFF3 during the 10 day period evaluated. TFF3 levels could not differentiate between various septic conditions in patients until a marked organ dysfunction developed. Higher Area Under Curve was noticed between control group and patients with sepsis. We could not make any strong conclusions based on mortality model. Conclusions: Levels of TFF3 are elevated in paediatric patients with sepsis through organ dysfunction.
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Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2013-08-28
zaakceptowano
2014-12-11
online
2015-04-24
Twórcy
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
autor
  • Faculty of Medicine, Masaryk University, Černopolní 9,
    Brno, 62500, Czech Republic
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
Bibliografia
  • [1] Derikx J.P., Poeze M., van Bijnen A.A., Buurman W.A., HeinemanE., Evidence for intestinal and liver epithelial cell injury in theearly phase of sepsis, Shock, 2007, 28, 544-548[WoS]
  • [2] Azzopardi N., Fenech M., Piscopo T., Sepsis, the Liver and theGut, Sepsis–An Ongoing and Significant Challenge, InTech,2012
  • [3] Puleo F., Arvanitakis M., Van Gossum A., Preiser J.C., Gut failurein the ICU, Semin Respir Crit Care Med., 2011, 32, 626-638[WoS]
  • [4] Mammen J.M.V.M., Matthews J.B.M., Mucosal repair in thegastrointestinal tract, Critical Care Medicine Healing Responsesin Critical Illness, 2003,31,S532-S537
  • [5] Thim L., A new family of growth factor-like peptides: ‘trefoil’disulphide loop structures as a common feature in breastcancer associated peptide (pS2), pancreatic spasmolyticpolypeptide (PSP) and frog skin peptides (spasmolysins), FEBSLett., 1989, 250, 85-90
  • [6] Hauser F., Poulsom R., Chinery R., Rogers L.A., HanbyA.M., Wright N.A., et al., hP1.B, a human P-domain peptidehomologous with rat intestinal trefoil factor, is expressed alsoin the ulcer-associated cell lineage and the uterus, Proc. Natl.Acad. Sci. USA, 1993, 90, 6961-6965
  • [7] Xian C.J., Howarth G.S., Mardell C.E., Cool J.C., Familari M.,Read L.C., et al., Temporal changes in TFF3 expression andjejunal morphology during methotrexate-induced damage andrepair, Am J Physiol, 1999,277, G785-G795
  • [8] Babyatsky M.W., deBeaumont M., Thim L., Podolsky D.K., Oraltrefoil peptides protect against ethanol- and indomethacininducedgastric injury in rats, Gastroenterology, 1996,110,489-497
  • [9] Schwarzberg H., Kalbacher H., Hoffmann W., Differentialbehavioral effects of TFF peptides: Injections of syntheticTFF3 into the ratamygdala, Pharmacol BiochemBehav,1999,62,173-178
  • [10] Goldstein B., Giroir B., Randolph A., International pediatricsepsis consensus conference: Definitions for sepsis and organdysfunction in pediatrics, Pediatr Crit Care Med, 2005, 6, 2-8[Crossref]
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  • [12] Ng E.W., Poon T.C., Lam H.S., Cheung H.M., Ma T.P., Chan K.Y.,et al., Gut-Associated Biomarkers L-FABP, I-FABP, and TFF3 andLIT Score for Diagnosis of Surgical Necrotizing Enterocolitis inPreterm Infants, Ann Surg. , 2013, 258, 1111-1118
  • [13] Vestergaard E.M., Poulsen S.S., Grønbaek H., LarsenR., Nielsen A.M., Ejskjaer K., et al., Development andevaluation of an ELISA for human trefoil factor 3, Clin Chem.,2002,48,1689-1695
  • [14] Moran P., Beasley H., Gorrell A., Martin E., Gribling P., Fuchs H.,et al., Human recombinant soluble decay accelerating factorinhibits complement activation in vitro and in vivo, J. Immunol.,1992, 149, 1736-1743
  • [15] Heeger P.S., Lalli P.N., Lin F., Valujskikh A., Liu J., Muqim N.,et al., Decay-accelerating factor modulates induction of T cellimmunity, J. Exp. Med., 2005, 201, 1523-1530
  • [16] Fink M.P., Delude R.L., Epithelial barrier dysfunction: aunifying theme to explain the pathogenesis of multiple organdysfunction at the cellular level, Crit Care Clin 2005, 2, 177-196
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0020
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