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2014 | 10 | 1 |
Tytuł artykułu

Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Based on the pivotal trial showing no clinicallyrelevant differences between pegylated interferon α-2b (Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin for treatment of chronic hepatitis C virus (HCV) genotype 1 infection in Ukraine, a cost-minimization analysis was performed using a 1 year time horizon and both a health care and patients’ perspective. A decision tree reflects treatment pathways. Drug costs were based on drug labeling and adjusted to the average body mass in Ukraine. Subgroup analysis was applied to deal with heterogeneity of patient’s weight causing dose changes. A break-even price of Peg-α-2a and Peg-α-2b (based on the average dose) was calculated. Univariate sensitivity analyses and probabilistic sensitivity analysis were carried out to reflect decision uncertainty. For an average body weight, total medical costs per patient differ from US$9220 for Peg-α-2b to US$9513 for Peg-α-2a from a health care perspective, and from US$15,212 to US$15,696 from a patients’ perspective. Sensitivity analyses show these results are robust. With average body weight, the break-even price of Peg-α-2b may be 7.3% higher than Peg-α-2a to have similar total costs.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
wydano
2015-01-01
otrzymano
2013-04-28
zaakceptowano
2014-01-08
online
2014-10-08
Twórcy
  • Institute of Health Policy &
    Management, Erasmus University Rotterdam, P.O. Box 1738, 3000
    DR Rotterdam, the Netherlands
autor
  • Dutch Health Care Insurance Board, PO Box 320.,
    1110 AH Diemen, the Netherlands; Institute of Health Policy & Management,
    Erasmus University Rotterdam, P.O. Box 1738, 3000 DR
    Rotterdam, the Netherlands
  • O. Bogomolets National Medical University, Shevchenko
    av. 13., 01601 Kyiv, Ukraine
  • P.L. Shupyk National Medical Academy of Postgraduate
    Education, Dorohozhyts’ka str. 9., 04112 Kyiv, Ukraine
autor
  • O. Bogomolets National Medical University, Shevchenko
    av. 13., 01601 Kyiv, Ukraine
  • L. Gromashevskyi Institute of Epidemiology
    and Infectious Diseases, Amosova str. 5., 03038 Kyiv, Ukraine
  • Danylo Halytsky Lviv National Medical University,
    Pekarska St. 69, 79010 Lviv, Ukraine
  • Institute of Health Policy & Management, Erasmus
    University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, the
    Netherlands, Institute of Medical Technology Assessment (iMTA),
    Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam,
    the Netherlands
Bibliografia
  • [1] Lawn SD, Wilkinson RJ, Lipman MCI, Wood R. Immune reconstitution and “unmasking” of tuberculosis during antiretroviral therapy. Am. J. Respir. Crit. Care Med. 2008 Apr 1;177(7):680-685[WoS]
  • [2] Cheng VCC, Ho PL, Lee RA, Chan KS, Chan KK, Woo PCY, et al. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. Eur. J. Clin. Microbiol. Infect. Dis. 2002 Nov;21(11):803-809[Crossref]
  • [3] Melboucy-Belkhir S, Flexor G, Stirnemann J, Morin A-S, Boukari L, Polliand C, et al. Prolonged paradoxical response to anti-tuberculous treatment after infliximab. Int. J. Infect. Dis. 2010 Sep;14 Suppl 3:e333-334[Crossref]
  • [4] Yoon YK, Kim JY, Sohn JW, Kim MJ, Koo JS, Choi JH, et al. Paradoxical response during antituberculous therapy in a patient discontinuing infliximab: a case report. J Med Case Reports. 2009;3:6673
  • [5] Garcia Vidal C, Rodríguez Fernández S, Martínez Lacasa J, Salavert M, Vidal R, Rodríguez Carballeira M, et al. Paradoxical response to antituberculous therapy in infliximab-treated patients with disseminated tuberculosis. Clin. Infect. Dis. 2005 Mar 1;40(5):756-759
  • [6] Hess S, Hospach T, Nossal R, et al. Life- threatening disseminated tuberculosis as a complication of TNF- a blockade in an adolescent. Eur J Pediatr. Volume 170, Number 10, 1337-1342
  • [7] Wallis RS (2008) Tumour necrosis factor antagonists: structure, function, and tuberculosis risks. Lancet Infect Dis 8: 601-611[Crossref][WoS]
  • [8] Brassard P, Kezouh A, Suissa S (2006) Antirheumatic drugs and the risk of tuberculosis. Clin Infect Dis 43: 717-722[WoS][Crossref]
  • [9] Wallis RS (2009) Infectious complications of tumor necrosis factor blockade. Curr Opin Infect Dis 22: 403-409[Crossref][WoS]
  • [10] Wallis RS, Broder MS, Wong JY et al (2004) Granulomatous infectious diseases associated with TNF antagonists. Clin Infect Dis 38: 1261-1265[Crossref]
  • [11] Wallis RS, Broder MS, Wong JY et al (2004) Granulomatous infections due to tumor necrosis factor blockade: correction. Clin Infect Dis 39: 1254-1256[Crossref]
  • [12] Meintjes G, Wilkinson RJ, Morroni C et al (2010) Randomized placebo- controlled trial of prednisone for paradoxical tuberculosis- associated immune reconstitution inflammatory syndrome. AIDS 24: 2381-2390[WoS]
  • [13] Wallis RS, Van Vuuren C, Potgieter S. Adalimumab treatment of life- threatening tuberculosis. Clin. Infect. Dis. 2009 May 15; 48 (10): 1429-1432
  • [14] Blackmore TK, Manning L, Taylor WJ, et al. Therapeutic use of infliximab in tuberculosis to control severe paradoxical reaction of the brain and lymph nodes. Clin. Infect. Dis. 2008 Nov 15; 47 (10): e 83-85
  • [15] Jurisic V, Stojacic- Djenic S, Colovic N and Konjevic G. The role of cytokine in regulation of the natural killer cell activity. Srp Arh Celok Lek. 2008 Jul-Aug;136(7-8):423-429
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0006
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