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2014 | 10 | 1 |
Tytuł artykułu

Endometrial cancer and microsatellite instability status

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid type adenocarcinoma. Material and methods: MSI status of endometrial cancer was examined by employing the Promega MSI Analysis System. This system uses 5 mononucleotide markers to identify MSI in tumour and normal tissue DNA (BAT-25, BAT-26, NR-21, NR-24, and MONO-27), and 2 pentanucleotide markers (Penta C and Penta D) for specimen identification. In this study, we investigated MSI status in 109 endometrial carcinomas. Results and conclusions: One hundred (92%) of 109 endometrial cancers showed endometrioid type histology and only 9 (8%) non-endometrioid type. MSI-high was found in 17% (17/100) of endometrioid type adenocarcinomas, in 0% (0/9) of non-endometrioid carcinomas. Selected clinicopathologic parameters for endometrioid type adenocarcinomas were compared to the MSI status which was separated into two groups – MSI-high and MSI stable. The results showed that MSI-high status was related to clinicopathologic parameters such as deep myometrial invasion and higher histologic grade in endometrioid type adenocarcinomas.
Wydawca

Czasopismo
Rocznik
Tom
10
Numer
1
Opis fizyczny
Daty
otrzymano
2013-11-13
zaakceptowano
2014-08-29
online
2014-11-11
Twórcy
  • Out Patient Clinic, National
    cancer institute, Santariskiu 1, LT-08660, Vilnius, Lithuania
  • Promega Corporation, Madison WI, USA
  • Radiotherapy and Drug Therapy
    Center, National cancer institute, Santariskiu 1, LT-08660, Vilnius,
    Lithuania
  • Scientific Research Center, National cancer institute,
    Santariskiu 1, LT-08660, Vilnius, Lithuania
  • Scientific Research Center, National cancer institute,
    Santariskiu 1, LT-08660, Vilnius, Lithuania
autor
  • Promega Corporation, Madison WI, USA
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_med-2015-0005
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