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2015 | 23 | 1 | 25-37
Tytuł artykułu

Variations in cognitive functioning in genetic generalized epilepsy: four case studies

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Introduction. The traditional view of cognition in idiopathic or genetic generalized epilepsy (GGE) is that “one size fits all” i.e. only very mild generalized impairment might be detected, if any. This paper describes four case studies of cognitive functioning in GGE patients with photosensitivity and reflexive seizures. Aim. The aim was to discover whether each individual’s set of cognitive deficits varied in accordance with his/her other clinical phenomena such as photosensitivity and kinds of reflexive seizures. Method. Neurological and cognitive performance was assessed by comprehensive evaluation of each patient based on interviews, neurologist’s EEG reports and neuropsychological tests. Assessment of cognitive domains included estimated pre-morbid I.Q. based on reading ability and demographic norms, current I.Q., attention factors, verbal memory, visual memory and executive functions. Results. Clinical signs and investigative studies indicated that two cases typically began reflexive seizure episodes with facial myoclonia which evolved into tonic-clonic convulsions or generalized myoclonic seizures. These patients had widespread attention and working memory deficits, some severe, together with lowered intelligence scores. In contrast, two other cases (with no history of myoclonus) had generalized reflexive seizures originating in the occipital lobes, very mild localized visual dysfunction and high intelligence. Conclusions. The systematic variation in extent and nature of cognitive dysfunction illustrated in these cases with reflexive seizures (preceded by myoclonia or visual phenomena) would be explained by a more recent conceptualization of GGE as encompassing regional differences in variable hyperexcitability located at cortical levels or functional neural networks.
Wydawca
Rocznik
Tom
23
Numer
1
Strony
25-37
Opis fizyczny
Daty
wydano
2015-06-01
otrzymano
2015-01-20
zaakceptowano
2015-03-16
online
2015-05-16
Twórcy
  • Department of Psychology, College of Healthcare Sciences, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia , evangelina.ballini@my.jcu.edu.au
  • Department of Psychology, College of Healthcare Sciences, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia
  • University of Cincinnati, Cincinnati, OH, USA
Bibliografia
  • Archer J.S., Warren A.E.L., Jackson G. D., Abbott D.F.:Conceptualizing Lennox-Gastaut syndrome as a secondary network epilepsy. Frontiers in Neurology, 2014a, 5: 225.[Crossref]
  • Archer J.S., Warren A.E.L., Stagnitti M.R., Masterton R.A.J., Abbott D.F., Jackson G.D.:Lennox-Gastaut syndrome and phenotype: Secondary network epilepsies. Epilepsia, 2014b, 55: 1245–1254. doi: 10.1111/epi.12682[WoS][Crossref]
  • Avanzini G., Manganotti P., Meletti S., Moshé S.L., Panzica F., Wolf P., Capovilla G.:The system epilepsies: a pathophysiological hypothesis. Epilepsia, 2012, 53: 771–778. doi: 10.1111/j.1528–1167.2012.03462.x[Crossref][PubMed][WoS]
  • Barton J.J.S. and Caplan L.R.:Cerebral visual dysfunction. In: J. Bogousslavsky, L.R. Caplan (Eds.), Stroke Syndromes (2nd ed.). Cambridge University Press, Cambridge 2001.
  • Bilgiç B., Baykan B., Gürses C., Gökyiğit A.:Perioral myoclonia with absence seizures: A rare epileptic syndrome. Epileptic Disorders, 2001, 3: 23–27.
  • Black L.C., Schefft B.K., Howe S.R., Szaflarski J.P., Yeh H., Privitera M.D.:The effect of seizures on working memory and executive functioning performance. Epilepsy and Behavior, 2010, 17: 412–419. doi: 10.1016/j.yebeh.2010.01.006[Crossref][PubMed]
  • Capovilla G., Striano P., Gambardella A., Beccaria F., Hirsch E., Casellato S. et al.:Eyelid fluttering, typical EEG pattern, and impaired intellectual function: a homogeneous epileptic condition among the patients presenting with eyelid myoclonia. Epilepsia, 2009, 50: 1536–1541. doi: 10.1111/j.1528–1167.2008.02002.x[PubMed][Crossref][WoS]
  • Covanis A.:Photosensitivity in idiopathic generalized epilepsies. Epilepsia, 2005, 46, Suppl. 9: 67–72. doi: 10.1111/j.1528–1167.2005.00315.x[Crossref][PubMed]
  • Destina Yalçin A., Forta H., Kilic E.:Overlap cases of eyelid myoclonia with absences and juvenile myoclonic epilepsy. Seizure, 2006, 15: 359–365.[WoS][Crossref][PubMed]
  • Destina Yalçin A., Kaymaz A., Forta H.:Reflex occipital lobe epilepsy. Seizure, 2000, 9: 436–441. doi: 10.1053/seiz.2000.0424[Crossref][WoS]
  • Devinsky O., Gershengorn J., Brown E., Perrine K., Vazquez B., Luciano D.:Frontal functions in juvenile myoclonic epilepsy. Neuropsychiatry, Neuropsychol. Behav. Neurol., 1997, 10: 243–246.
  • Ferlazzo E., Zifkin B.G., Andermann E., Andermann F.:Cortical triggers in generalized reflex seizures and epilepsies. Brain, 2005, 128: 700–710. doi: 10.1093/brain/awh446[PubMed][Crossref]
  • Goodale M.A.:Perception and action in the human visual system. In: M.A. Gazzaniga (Ed.), The new cognitive neurosciences (2nd ed.). Cambridge, MA, MIT Press 2000.
  • Guerrini R., Dravet C., Genton P., Bureau M., Bonanni P., Ferrari A.R. et al.:Idiopathic photosensitive occipital lobe epilepsy. Epilepsia, 1995, 36: 883–891. doi: 10.1111/j.1528–1157.1995.tb01631.x[PubMed][Crossref]
  • Gülgönen S., Demirbilek V., Korkmaz B., Dervent A., Townes B.D.:Neuropsychological functions in idiopathic occipital lobe epilepsy. Epilepsia, 2000, 41: 405–411. doi: 10.1111/j.1528–1157.2000.tb00181.x[PubMed][Crossref]
  • Hommet C., Sauerwein H.C., De Toffol B., Lassonde M.:Idiopathic epileptic syndromes and cognition. Neuroscience and Biobehavioral Reviews, 2006, 30: 85–96. doi: 10.1016/j.neubiorev.2005.06.004[Crossref]
  • Kent G.P., Schefft B. K., Howe S.R., Szaflarski J.P., Yeh H.-S., Privitera M.D.:The effects of duration of intractable epilepsy on memory function. Epilepsy and Behavior, 2006, 9: 469–477. doi: 10.1016/j.yebeh.2006.07.005[Crossref][PubMed]
  • Levine D.N., Warach J., Farah M.:Two visual systems in mental imagery: Dissociation of ‘what’ and ‘where’ in imagery disorder due to bilateral posterior cerebral lesions. Neurology, 1985, 35: 1010–1018.[PubMed][Crossref]
  • Mayer T.A., Schroeder F., May T.W., Wolf P.T.:Perioral reflex myoclonias: a controlled study in patients with JME and focal epilepsies. Epilepsia, 2006, 47: 1059–1067. doi: 10.1111/j.1528-1167.2006.00575.x[Crossref][PubMed]
  • Panayiotopoulos C.P.:Idiopathic generalized epilepsies: a review and modern approach. Epilepsia, 2005a, 46 Suppl. 9: 1–6. doi: 10.1111/j.1528–1167.2005.00330.x[Crossref]
  • Panayiotopoulos C.P.:Syndromes of idiopathic generalized epilepsies not recognized by the International League Against Epilepsy. Epilepsia, 2005b, 46 Suppl. 9: 57–66. doi: 10.1111/j.1528–1167.2005.00314.x[Crossref]
  • Schefft B.K., Dulay M.F., Fargo J.D., Szaflarski J.P., Yeh H.S., Privitera, M.D.:The use of self-generation procedures facilitates verbal memory in individuals with seizure disorders. Epilepsy and Behavior, 2008, 13: 162–168. doi: 10.1016/j.yebeh.2008.01.012[PubMed][Crossref]
  • Shorvon S., Walker M.:Status epilepticus in idiopathic generalized epilepsy. Epilepsia, 2005, 46 Suppl. 9: 73–79. doi: 10.1111/j.1528–1167.2005.00316.x[Crossref]
  • Szabo C.A.:Reflex Epilepsy. eMedicine Neurology, 2010.
  • Taylor I., Marini C., Johnson M.R., Turner S., Berkovic S.F., Scheffer I.E.:Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap? Brain, 2004, 127: 1878–1886. doi: 10.1093/brain/awh211[Crossref][PubMed]
  • Taylor I., Scheffer I.E., Berkovic S.F.:Occipital epilepsies: identification of specific and newly recognized syndromes. Brain, 2003, 126: 753–769. doi: 10.1093/brain/awg080[PubMed][Crossref]
  • Turnbull O.H., Carey D.P., McCarthy R.A.:The neuropsychology of object constancy. Journal of the International Neuropsychological Society, 1997, 3: 288–298.
  • Wolf P.:Historical aspects of idiopathic generalized epilepsies. Epilepsia, 2005, 46, Suppl. 9: 7–9. doi: 10.1111/j.1528–1167.2005.00308.x[PubMed][Crossref]
  • Wolf P.:Basic principles of the ILAE syndrome classification. Epilepsy research, 2006, 70: 20–26. doi: 10.1016/j.eplepsyres.2006.01.015[Crossref]
  • Wolf P. and Koepp M.:Reflex epilepsies. Handbook of Clinical Neurology, 2012, 107: 257–276. doi: 10.1016/B978–0–444–52898–8.00016–1[Crossref]
  • Zifkin B.G.:Some lessons from reflex seizures. Epilepsia, 2010, 51 Suppl. 1: 43–44. doi: 10.1111/j.1528–1167.2009.02443.x[WoS][Crossref][PubMed]
  • Zifkin B.G., Inoue Y.:Visual reflex seizures induced by complex stimuli. Epilepsia, 2004, 45 Suppl. 1: 27–29. doi: 10.1111/j.0013–9580.2004.451005.x[Crossref][PubMed]
  • Zifkin B.G., Trenite D.K.N.:Reflex epilepsy and reflex seizures of the visual system: A clinical review. Epileptic Disorders, 2000, 2: 129–136.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_joepi-2015-0024
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