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2014 | 22 | 2 | 99-108
Tytuł artykułu

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Introduction. Epilepsy that is associated with neurocutaneous disorders seriously deteriorates quality of life and cognitive outcome of affected children. Recent advances in epilepsy pathophysiology raise hopes for better treatment results in this difficult group of patients. Aim. The aim of this review is to present recent treatment recommendations as well as current research progress in the most frequent neurocutaneous disorders. Material and methods. We analyzed PubMed database to select the most prominent and recent (up to 2014 year) publications on the treatment and mechanisms of epilepsy in selected neurocutaneous disorders. We aimed to emphasize evidence-based medicine recommendations as well as basic experimental studies dealing with molecular mechanisms of epileptogenesis. Discussion and conclusions. Recent advances in disease-modifying treatment options such as mTOR inhibitors in patients with tuberous sclerosis complex open up new perspectives for neurologists. Traditional resective surgery has still a major role as a treatment of choice in carefully selected cases.
Wydawca

Rocznik
Tom
22
Numer
2
Strony
99-108
Opis fizyczny
Daty
wydano
2014-12-01
otrzymano
2014-07-24
zaakceptowano
2014-10-03
online
2015-03-01
Twórcy
  • Department of Neurology and Epileptology, The Children's Memorial Health Institute, Warsaw
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_joepi-2015-0017
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