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2013 | 21 | 2 | 79-87
Tytuł artykułu

Effect of plant polyphenols on seizures – animal studies

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Introduction. Flavonoids are a large group of natural compounds that have been considered to be beneficial in ameliorating some age-dependent disorders. However, a potential use of these compounds in epilepsy treatment has not been systematically reviewed. Aim. This review describes the pharmacological activity of some polyphenols (flavonoids) in different animal models of seizures e.g. pentylenetetrazole-induced seizures, kainate-induced seizures and pentylenetetrazole kindling in rats. Method and Discussion. A literature review was conducted using PubMed from 1963 to October 2013 relating effects of flavonoids on experimentally-induced seizures in rodents. Articles chosen for references were queried with the following prompts: “flavonoids and epilepsy”, “flavonoids and seizures”, “plant polyphenols and epilepsy”, and “plant polyphenols and seizures”. Out of 84 reports 32 pharmacological studies with chemically well-defined flavonoids and using widely accepted animal models of seizures have been taken into account in this review. No clinical data on the antiepileptic effect of flavonoids have been reported so far. Conclusion. The reviewed data suggest the possible benefits of some chemically well-defined polyphenolic compounds of plant origin in antiepileptic treatment. Among flavonoids, resveratrol, baicalein, quercetin and rutin showed significant antiseizure activity. The ability of flavonoids to prevent brain excitability and to protect the brain against oxidative stress-induced damage suggests a potential use of some flavonoids at least as adjunctive therapy for the treatment of epilepsy.
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Opis fizyczny
  • Institute of Pharmacology PAS, Krakow, Poland
  • Abbasi E., Nassiri-Asl M., Shafeei M., Sheikhi M.:Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. Chem. Biol. Drug Des., 2012, 80: 274–278.[WoS]
  • Abd El Mohsen M.M., Kuhnle G., Rechner A.R., Schroeter H., Rose S., Jenner P., Rice-Evans C.A.:Uptake and metabolism of epicatechin and its access to the brain after oral ingestion.Free. Radic. Biol. Med., 2002, 33: 1693–1702.[Crossref]
  • Andres-Lacueva C., Shukitt-Hale B., Galli R.L., Jauregui O., Lamuela-Raventos R.M., Joseph J.A.:Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr. Neurosci., 2005, 8: 111–120.[Crossref]
  • Beking K. and Vieira A.:Flavonoid intake and disabilityadjusted life years due to Alzheimer's and related dementias: a population-based study involving twenty-three developed countries. Public Health Nutr., 2010, 13: 1403–1409.[WoS][Crossref]
  • Commenges D., Scotet V., Renaud S., Jacqmin-Gadda H., Barberger-Gateau P., Dartigues J.F.:Intake of flavonoids and risk of dementia. Eur. J. Epidemiol., 2000, 16: 357–363.[Crossref][PubMed]
  • Crozier A., Jaganath I.B., Clifford M.N.:Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep., 2009, 26: 1001–1043.[PubMed][Crossref][WoS]
  • de Carvalho R.S., Duarte F.S., de Lima T.C.:Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice. Behav. Brain Res., 2011, 221: 75–82.[WoS]
  • Dimpfel W.:Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro. J. Pharm. Pharmacol., 2006, 58: 375–379.[Crossref]
  • Du X.M., Sun N.Y., Takizawa N., Guo Y.T., Shoyama Y.:Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana. Phytother. Res., 2002, 16: 261–263.[PubMed][Crossref]
  • Faria A., Pestana D., Teixeira D., Couraud P.O., Romero I., Weksler B. et al.:Insights into the putative catechin and epicatechin transport across blood-brain barrier. Food Funct., 2011, 2: 39–44.[Crossref][PubMed][WoS]
  • Fernández S.P., Wasowski C., Loscalzo L.M., Granger R.E., Johnston G.A., Paladini A.C., Marder M.:Central nervous system depressant action of flavonoid glycosides. Eur. J. Pharmacol., 2006, 539: 168–176.
  • Friedman L.K., Goldstein B., Rafiuddin A., Roblejo P., Friedman S.:Lack of resveratrol neuroprotection in developing rats treated with kainic acid. Neuroscience, 2013, 230: 39–49.[WoS]
  • Garg S.K., Kumar N., Bhargava V.K., Prabhakar S.K.:Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin. Pharmacol. Ther., 1998, 64: 286–288.[Crossref][PubMed]
  • Golechha M., Chaudhry U., Bhatia J., Saluja D., Arya D.S.:Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol. Pharm. Bull., 2011, 34: 360–365.[Crossref][WoS][PubMed]
  • Griebel G., Perrault G., Tan S., Schoemaker H., Sanger D.J.:Pharmacological studies on synthetic flavonoids: comparison with diazepam. Neuropharmacology, 1999, 38: 965–977.[Crossref][PubMed]
  • Gupta Y.K., Briyal S., Chaudhary G.:Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats. Pharmacol. Biochem. Behav., 2002b, 71: 245–249.
  • Gupta Y.K., Chaudhary G., Sinha K., Srivastava A.K.:Protective effect of resveratrol against intracortical FeCl3-induced model of posttraumatic seizures in rats. Methods Find. Exp. Clin. Pharmacol., 2001, 23: 241–244.[Crossref]
  • Gupta Y.K., Chaudhary G., Srivastava A.K.:Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. Pharmacology, 2002a, 65: 170–174.[Crossref][PubMed]
  • Hamada H., Hiramatsu M., Edamatsu R., Mori A.:Free radical scavenging action of baicalein. Arch. Biochem. Biophys., 1993, 306: 261–266.
  • Han J.Y., Ahn S.Y., Kim C.S., Yoo S.K., Kim S.K., Kim H.C. et al.:Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. Biol. Pharm. Bull., 2012, 35: 1440–1446.[Crossref][PubMed]
  • Hu K., Li S.Y., Xiao B., Bi F.F., Lu X.Q., Wu X.M.:Protective effects of quercetin against status epilepticus induced hippocampal neuronal injury in rats: involvement of X-linked inhibitor of apoptosis protein. Acta Neurol. Belg., 2011, 111: 205–212.
  • Joshi D., Naidu P.S., Singh A., Kulkarni S.K.:Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions. J. Med. Food, 2005, 8: 392–396.[Crossref]
  • Kabuto H., Yokoi I., Mori A.:Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins. Neurochem Res., 1992, 17: 585–590.[Crossref][PubMed]
  • Kavvadias D., Sand P., Youdim K.A., Qaiser M.Z., Rice-Evans C., Baur R. et al.:The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br. J. Pharmacol., 2004, 142: 811–820.
  • Kim H.J., Kim I.K., Song W., Lee J., Park S.:The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice. Neurochem Res., 2013, 38: 117–122.[PubMed][WoS][Crossref]
  • Kumar A., Lalitha S., Mishra J.:Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice. Epilepsy Behav., 2013, 29: 103–111.[Crossref][WoS][PubMed]
  • Lin T.Y., Lu C.W., Wang C.C., Lu J.F., Wang S.J.:Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. Toxicol. Appl. Pharmacol., 2012, 263: 233–243.[WoS]
  • Liu Y.F., Gao F., Li X.W., Jia R.H., Meng X.D., Zhao R., Jing Y.Y. et al.:The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. Neurochem. Res., 2012, 37: 1670–1680.[Crossref][PubMed][WoS]
  • Majkowski J.:Epileptogenesis – the role of oxygen stress. Epileptologia, 2007, 15: 225–240.
  • Medina J.H., Paladini A.C., Wolfman C., Levi de Stein M., Calvo D., Diaz L.E., Peña C.:Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem. Pharmacol., 1990, 40: 2227–2231.[Crossref]
  • Metzler M., Pfeiffer E., Schulz S.I., Dempe J.S.:Curcumin uptake and metabolism. Biofactors, 2013, 39: 14–20.[Crossref][WoS][PubMed]
  • Nassiri-Asl M., Moghbelinejad S., Abbasi E., Yonesi F., Haghighi MR., Lotfizadeh M., Bazahang P.:Effects of quercetin on oxidative stress and memory retrieval in kindled rats. Epilepsy Behav., 2013, 28: 151–155.[WoS][Crossref]
  • Nassiri-Asl M., Mortazavi S.R., Samiee-Rad F., Zangivand A.A., Safdari F., Saroukhani S., Abbasi E.:The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats. Epilepsy Behav., 2010, 18: 50–53.[WoS][Crossref]
  • Nassiri-Asl M., Shariati-Rad S., Zamansoltani F.:Anticonvulsive effects of intracerebroventricular administration of rutin in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008, 32: 989–993.[WoS][Crossref]
  • Nitsinskaia L.E., Ekimova I.V., Guzhova I.V., Feĭzulaev B.A., Pastukhov Iu F.:Effect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures. Ross. Fiziol. Zh. Im. I.M. Sechenova., 2010, 96: 283–292.
  • Nones J.E., Spohr T.C., Gomes F.C.:Hesperidin, a flavone glycoside, as mediator of neuronal survival. Neurochem. Res., 2011, 36: 1776–1784.[PubMed][WoS][Crossref]
  • Nugroho A., Lim SC., Choi J., Park H.J.:Identification and quantification of the sedative and anticonvulsant flavone glycoside from Chrysanthemum boreale. Arch Pharm Res., 2013, 36: 51–60.[WoS][Crossref][PubMed]
  • Shetty A.K.:Promise of resveratrol for easing status epilepticus and epilepsy. Pharmacol. Ther., 2011, 131: 269–286.[WoS]
  • Svenningsen A.B., Madsen K.D., Liljefors T., Stafford G.I., van Staden J., Jäger A.K.:Biflavones from Rhus species with affinity for the GABA(A)/benzodiazepine receptor. J. Ethnopharmacol., 2006, 103: 276–280.
  • Tsaryuk V.V., Potapovich A.I., Kostyuk V.A.:Protective effect of copper-rutin complex in animals with experimental epilepsy. Bull. Exp. Biol. Med., 2002, 133: 334–335.
  • Vauzour D., Vafeiadou K., Rice-Evans C., Williams R.J., Spencer J.P.:Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. J. Neurochem., 2007, 103: 1355–1367.[WoS]
  • Wang F., Xu Z., Ren L., Tsang S.Y., Xue H.:GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin. Neuropharmacology, 2008, 55: 1231–1237.[WoS][Crossref]
  • Wang S.J., Bo Q.Y., Zhao X.H., Yang X., Chi Z.F., Liu X.W.:Resveratrol pre-treatment reduces early inflammatory responses induced by status epilepticus via mTOR signaling. Brain Res., 2013, 1492: 122–129.[WoS]
  • Witkin J.M., Terry P., Menkel M., Hickey P., Pontecorvo M., Ferkany J., Katz J.L.:Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine. J. Pharmacol. Exp. Ther., 1993, 266: 473–482.
  • Wolfman C., Viola H., Marder M., Ardenghi P., Wasowski C., Schröder N. et al.:Pharmacological characterization of 6-bromo-3’-nitroflavone, a synthetic flavonoid with high affinity for the benzodiazepine receptors. Pharmacol. Biochem. Behav., 1998, 61: 239–246.[Crossref]
  • Wu Z., Xu Q., Zhang L., Kong D., Ma R., Wang L.:Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochem. Res., 2009, 34: 1393–1400.[PubMed][Crossref]
  • Xie T., Wang W.P., Mao Z.F., Qu Z.Z., Luan S.Q., Jia L.J., Kan M.C.:Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats. Neurosci. Lett., 2012, 516: 237–241.
  • Yoon S.Y., dela Peña I.C., Shin C.Y., Son K.H., Lee Y.S., Ryu J.H. et al.:Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures. Eur. J. Pharmacol., 2011, 659: 155–160.[WoS]
  • Yokoi I., Kabuto H., Akiyama K., Mori A., Ozaki M.:Tannins inhibit the occurrence of epileptic focus induced by FeCl3 injection in rats. Jpn. J. Psychiatry Neurol., 1989, 43: 552–553.
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