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2015 | 2 | 1 |
Tytuł artykułu

Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer’s disease

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The endoplasmic reticulum (ER) is an organelle that plays a crucial role in protein quality control such as protein folding. Evidence to indicate the involvement of ER in maintaining cellular homeostasis is increasing. However, when cells are exposed to stressful conditions, which perturb ER function, unfolded proteins accumulate leading to ER stress. Cells then activate the unfolded protein response (UPR) to cope with this stressful condition. In the present review, we will discuss and summarize recent advances in research on the basic mechanisms of the UPR. We also discuss the possible involvement of ER stress in the pathogenesis of Alzheimer’s disease (AD). Potential therapeutic opportunities for diseases targeting ER stress is also described.
Wydawca
Rocznik
Tom
2
Numer
1
Opis fizyczny
Daty
otrzymano
2015-06-30
zaakceptowano
2015-09-01
online
2015-10-19
Twórcy
autor
  • Department of Pharmacotherapy,
    Graduate School of Biomedical and Health Sciences, Hiroshima
    University, Hiroshima 734-8553, Japan
autor
  • Department of Biomedical Research, Graduate School
    of Biomedical and Health Sciences, Hiroshima University, Hiroshima
    734-8553, Japan
  • Department of Pharmacotherapy,
    Graduate School of Biomedical and Health Sciences, Hiroshima
    University, Hiroshima 734-8553, Japan
  • Department of
    Pharmacology, Kurume University School of Medicine, Kurume,
    Fukuoka 830-0011, Japan
  • Department of
    Pharmacology, Kurume University School of Medicine, Kurume,
    Fukuoka 830-0011, Japan
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_ersc-2015-0008
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