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2015 | 28 | 3 | 204-207
Tytuł artykułu

Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.
Wydawca

Rocznik
Tom
28
Numer
3
Strony
204-207
Opis fizyczny
Daty
wydano
2015-09-01
otrzymano
2015-07-02
zaakceptowano
2015-08-20
online
2015-11-26
Twórcy
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland, jarogniew.luszczki@gmail.com
  • Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
Bibliografia
  • 1. Barton M.E. et al.: Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res., 47, 217, 2001.
  • 2. Deckers C.L.P. et al.: Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia, 41, 1364, 2000.
  • 3. Dooley D.J., Taylor C.P., Donevan S., Feltner D.: Ca2+ channel alpha2delta ligands: novel modulators of neurotransmission. Trends Pharmacol. Sci., 28, 75, 2007. Erratum in: Trends Pharmacol. Sci., 28, 151, 2007.
  • 4. Dudra-Jastrzebska M. et al.: Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. Eur. J. Pharmacol., 605, 87, 2009.[WoS]
  • 5. Fisher R.S. et al.: ILAE official report: a practical clinical definition of epilepsy. Epilepsia, 55, 475, 2014.[WoS]
  • 6. Florek-Łuszczki M., Wlaź A., Łuszczki J.J.: Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and vigabatrin in the mouse 6Hz psychomotor seizure model - A type II isobolographic analysis. Eur. J. Pharmacol., 723, 410, 2014.[WoS]
  • 7. Kwan P., Brodie M.J.: Combination therapy in epilepsy: when and what to use. Drugs, 66, 1817, 2006.
  • 8. Litchfield J.T., Wilcoxon F.: A simplified method of evaluating doseeffect experiments. J. Pharmacol. Exp. Ther., 96, 99, 1949.
  • 9. Łuszczki J.J., Czuczwar S.J.: Preclinical profile of combinations of some second-generation antiepileptic drugs: an isobolographic analysis. Epilepsia, 45, 895, 2004.
  • 10. Łuszczki J.J. et al.: Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model - an isobolographic analysis. Curr. Issues Pharm. Med. Sci., 26, 82, 2013.
  • 11. Łuszczki J.J. et al.: Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis. J. Pre-Clin. Clin. Res., 8, 76, 2014.
  • 12. Łuszczki J.J. et al.: Isobolographic characterization of interaction of levetiracetam with clobazam in the mouse 6 Hz psychomotor seizure model. J. Pre-Clin. Clin. Res., 6, 25, 2012.
  • 13. Lynch B.A. et al.: The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. USA, 101, 9861, 2004.
  • 14. Perucca E.: Pharmacological principles as a basis for polytherapy. Acta Neurol. Scand., Suppl. 162, 31, 1995.
  • 15. Shandra A. et al.: Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice. Epilepsia, 54, 1167, 2013.
  • 16. Tallarida R.J., (2000). Drug synergism and dose-effect data analysis. Chapman & Hall/CRC, Boca Raton.
  • 17. Wojda E. et al.: Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. Epilepsy Res., 86, 163, 2009. [WoS]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0073
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