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2015 | 28 | 3 | 200-203
Tytuł artykułu

Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Non-selective cyclooxygenase (COX) inhibitors, commonly referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are among the most taken pharmaceuticals. In adults, they can have a series of side effects, including especially gastroenterotoxicity, hepatotoxicity, nephrotoxicity, chondrotoxicity, and neurotoxicity, and they can induce allergic reactions. Any exacerbation of symptoms depends on the chemical structure of the drug, its dosage and duration of exposure, individual sensitivity, comorbidities and the degree of inhibition of basic COX isoenzymes - the constitutive (COX-2) and induced (COX-1) expressions. However, data on prenatal toxicity are inconsistent. Classic nonselective COX inhibitors do not result in an increase in the risk of developing significant congenital defects; however, if used in the late-pregnancy period, they can have an adverse effect on the foetus, by inducing the premature closure of the ductus arteriosus and by producing a tocolytic effect. Individual reports also indicate the increased risk of developing heart and anterior abdominal wall defects, as well as hypospadias.
Wydawca

Rocznik
Tom
28
Numer
3
Strony
200-203
Opis fizyczny
Daty
wydano
2015-09-01
otrzymano
2015-07-09
zaakceptowano
2015-08-26
online
2015-11-26
Twórcy
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Chair and Department of Rehabilitation and Orthopaedics, Medical University of Lublin, Jaczewskiego 8, 20-950 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
autor
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
autor
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland, wojciech686@wp.pl
Bibliografia
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  • 6. Burdan F. et al.: Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors. Braz. J. Med. Biol. Res., 39, 925-934, 2006.
  • 7. Burdan F. et al.: Immuno-expression of the constitutive and inducible cyclo-oxygenase isoforms in maternal and fetal rat lungs. Ann. Univ. Mariae Curie Sklodowska Med. [Sectio D], 61, 330-334, 2006.
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  • 9. Burdan F. et al.: Prenatal effects of DuP-697 - the irreversible, highly selective cyclo-oxygenase-2 inhibitor. Reprod. Toxicol., 17, 413-419, 2003.
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  • 39. Torfs C.P. et al.: Maternal medications and environmental exposures as risk factors for gastroschisis. Teratology, 54, 84-92, 1996.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0072
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