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2015 | 28 | 2 | 120-125
Tytuł artykułu

Effect of compression pressure on mechanical and release properties of tramadol matrix tablets

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Drug delivery to the proper site of action in the body is greatly influenced by the excipients used and some processing variables such as changes in compression force. The aim of this investigation was to study the influence of changes in compression forces during tablet manufacturing on the mechanical and release properties of Tramadol matrix tablet. Hardness and friability were used as assessment parameters for mechanical properties while release properties were analysed using dissolution test. Data were analysed using One-way ANOVA at p < 0.05. Tablet hardness and friability were typically compression pressure-dependent with a significant difference in tablet hardness and friability with increase in compression pressure (p < 0.001). Drug release was best expressed by Korsmeyer-Peppas equation as the plots showed high linearity (r2) of 0.998 and 0.988 for formulations containing Xanthan gum and Sodium carboxymethylcellulose, respectively. Drug release from formulations containing Xanthan gum was mainly by diffusion while a combination of diffusion and chain relaxation was the mechanism of drug release from formulation containing Sodium Carboxymethylcellulose. The release properties of tramadol matrix tablet were not significantly influenced by compression pressure but rather by the polymer and the material properties of the drug.
Wydawca

Rocznik
Tom
28
Numer
2
Strony
120-125
Opis fizyczny
Daty
wydano
2015-06-01
otrzymano
2015-02-16
zaakceptowano
2015-04-21
online
2015-07-16
Twórcy
  • Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria, olutayoadeleye@yahoo.com
  • Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria
  • Department of Pharmaceutics And Industrial Pharmacy, University of Ibadan, Nigeria
Bibliografia
  • 1. Adeleye O.A., Femi-Oyewo M.N., Odeniyi M.A.: The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipients. Poly. Med., 44(4), 209, 2014.
  • 2. Adeleye A.O., Odeniyi M.A., Jaiyeoba K.T.: The influence of cissus gum on the mechanical and release properties of paracetamol tablets - a factorial analysis. J. Basic and Appl. Pharm. Sci., 31(2), 131, 2010.
  • 3. Adeleye A.O., Odeniyi M.A., Jaiyeoba K. T.: Evaluation of cissus gum as binder in a paracetamol tablet formulation. Farmacia, 59(1), 85, 2011.
  • 4. Banker G.S., Anderson N.R. (1986). The theory and practice of Industrial Pharmacy. Lachman L., Liebeman H. A., Kanig J. L. (editors), 2nd edition. Philadelphia: Lea and Febger; p. 293.
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  • 7. El-Bagory I. et al.: Formulation and in vitro evaluation of theophylline matrix tablets prepared by direct compression: Effect of polymer blends. Saudi Pharm. J., 20, 229-238, 2012.
  • 8. Femi-Oyewo M.N., Aremu O.I., Kehinde O.J.: Evaluation of Beilschmiedia seed gum as a tablet binder. East and Central Afr. J. Pharm. Sci., 12(2), 15, 2009.
  • 9. Garekani H.A. et al.: Effect of compression force, compression speed and particle size on the compression properties of paracetamol. Drug Dev. Ind. Pharm., 27, 935-42, 2001.[Crossref]
  • 10. Haresh T.M., Bhumin P. and Nehal J.S.: Development of pH -independent matrix type sustained release drug delivery system of propranolol hydrochloride. J. Appl. Pharm. Sci., 1(3), 83-92, 2011.
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  • 12. Ibrahim H., Rai P.P., Bangudu A. B.: Evaluation of mucilage from the stem bark of Cissus populnea. Afri. J. of Pharm. Sci., 22(1), 35, 1991.
  • 13. Johan V.E.: Tablet compression: Improving Tablet Quality with Compression to Equal Force Technology. Supplement to pharmaceutical technology, the industry’s authoritative source. An advanced star publication. Pharm. Tech., 1, 2008.
  • 14. Kalu V.D., Odeniyi M.A., Jaiyeoba K.T.: Matrix properties of a new plant gum in controlled drug delivery. Arch. Pharm. Res., 30(7), 884, 2005.[Crossref][WoS]
  • 15. Korsmeyer R.W., Gurny R., Peppas N. A.: Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm., 15, 25, 1983.[Crossref]
  • 16. Lobman K., et al.: The influence of pressure on the intrinsic dissolution rate of amorphous indomethacin. Pharmaceutics, 6, 481, 2014.[Crossref]
  • 17. Lunio R. et al.: Compressibility of gastroretentive pellets coated with Eudragit NE using a single-stroke and a rotary tablet press. Pharm. Dev. Technol., 13(4), 323-31, 2008.[Crossref][WoS]
  • 18. Marais A.F. et al: Effect of compression force, humidity and disintegrant concentration on the disintegration and dissolution of directly compressed furosemide tablets using croscarmellose sodium as disintegrant. Trop. J. Pharm. Res., 2(1), 125-135, 2003.
  • 19. Nanjwande B.K.: Effect of pressure on dissolution and solid state characterization of cefuroxime axetil. J. Anal. Bioana. Tech., 1(3), 112, 2010.
  • 20. Narang A.S. et al.: Effect of force feeder on tablet strength during compression. Int. J. Pharm., 401(1-2), 7-15, 2010.[WoS]
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  • 23. Ritschel W.A., Bauer-Brandl A. (2002). Die Tablette. Canter Verlag, Aulendorf (editors), 2nd Edition. p. 518
  • 24. Rubinstein M.H. (2000). Tablets. In: Pharmaceutics, the science of dosage form design. Aulton M.E. (editor). Churchill Livingstone, Edinburgh London Melbourne and New York. p. 305.
  • 25. Santos J.V., Batista A.E., Pina M.E.: The influence of the compression force on zidovudine release from matrix tablets. AAPS PharmSci. Tech., 11(3), 1442, 2010.[Crossref]
  • 26. Shailender M.: Compression physics of pharmaceutical powders: A review. Int. J. Sci. Res., 3(6), 1580, 2012.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0057
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