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2015 | 28 | 2 | 81-84
Tytuł artykułu

The inflluence of emulsifiers on physical properties and release parameters of creams with caffeine

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Caffeine is well known alkaloid chemical compound belonging to the methyl-xanthines group. It is an active substance that is found in many cosmetic products, as it has a stimulating action on both the central nervous system and the metabolism. Commercially available topical formulations normally contain 3% of caffeine and 7% anticellulite products. The aim of our work was to investigate the properties of four cream preparations. These consisted of 5% of caffeine and one of four different emulsifiers (GSC, Sodium polyacrylate, Emulsifying Base, MDS). In our work, we compared the physical properties (spreadability, slip and tenacity), the rheological structure of the resulting creams and the caffeine release from the obtained preparations. The results showed that the properties of these creams and their drug release depended upon the kind of the emulsifiers utilised. What is more, all preparations have a pseudoplastic character of flow and most of them have significant thixotropy. Furthermore, the amount of released caffeine is the largest from the MDS cream, and this emulsifier seems to be the most optimal in all the examined items.
Słowa kluczowe
Wydawca

Rocznik
Tom
28
Numer
2
Strony
81-84
Opis fizyczny
Daty
wydano
2015-06-01
otrzymano
2015-03-18
zaakceptowano
2015-04-30
online
2015-07-16
Twórcy
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland, dor.dwor@wp.pl
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
autor
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
autor
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
Bibliografia
  • 1. Achim M. et al.: Topical dosage forms containing fluid-extract of ruscus aculeatus: Formulation, preparation and physical characterization. Clujul Medical. 83, 99-103, 2010.
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  • 5. Davis M.G. et al.: A novel cosmetic approach to treat thinning hair. Brit.J.Derm.,65, 24-30, 2011.[Crossref]
  • 6. Erös I., Thaleb A.: Rheological studies of creams. I. Rheological functions and structure of creams. Acta Pharm. Hung., 64, 101-103, 1994.
  • 7. Erös I., Thaleb A.: Rheological studies of creams. II. Effect of water content on rheological characteristics. Acta Pharm. Hung., 66, 71-76, 1996.
  • 8. Erös I., Thaleb A.: Rheological studies of creams. III. Effect of lipophilic phase on consistency. Acta Pharm. Hung., 66, 77-81, 1996.
  • 9. Fiebig A., Janicki St., Sznitowska M.: Farmacja stosowana. PZWL, Warszawa, 2004.
  • 10. Fischer T.W.,Hipler U.C., Elsner P.: Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. Int. J. Derm., 46, 27-35, 2007.[Crossref]
  • 11. Krówczyński L.: Technologia postaci leków. PZWL, Warszawa, 1969.
  • 12. Otberg N. et al.: The role of hair follicles in the percutaneous absorption of caffeine. Br. J. Clin. Pharmacol., 65, 488-492, 2008.[WoS][Crossref]
  • 13. Polish Pharmacopea IX, Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych I Produktów Bójczych, Warszawa, 2011.
  • 14. Provost C., Kinget R., Herbots H.: The influence of emulsifiers on drug diffusion from o/w cream. Pharm. Weekbl. Sci., 18, 248-251, 1981.
  • 15. Roure R. et al.: Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, in vitro, ex vivo and in vivo studies. Int. J. Cosm. Sci., 33, 519-526, 2011.[Crossref]
  • 16. Sainio E., Rantanen T.,Kanerva L.: Ingredients and safety of cellulite creams. Eur. J. Dermatol., 10, 596-603, 2000.
  • 17. Vogelgesang B. et al.: In vitro and in vivo efficacy of sulfo-carrabiose, a sugar-based cosmetic ingredient with anti-cellulite properties. Int. J. Cosm. Sci., 33, 120-125, 2011.[Crossref]
  • 18. Wilkinson S.C. et al.: Interactions of skin thickness and physiochemical properties of test compounds in percutaneous penetration studies. Int. Archiv. Occup. Envir Health., 79, 05-413, 2006.[Crossref]
  • 19. Wojciechowska K. et al.: Physical properties and caffeine release from creams prepared with different oils. Curr. Issues Pharm. Med. Sci., 27, 224-228, 2014.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0049
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