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2014 | 27 | 4 | 240-242
Tytuł artykułu

Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.
Wydawca

Rocznik
Tom
27
Numer
4
Strony
240-242
Opis fizyczny
Daty
wydano
2014-12-01
otrzymano
2014-11-07
zaakceptowano
2014-12-12
online
2015-03-03
Twórcy
autor
  • Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine, ogerush@mail.ru
  • National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine
  • National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine
  • National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine
autor
  • Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine
Bibliografia
  • 1. Kamyshnikov V.S. (2000). Reference book on clinical-biochemical laboratory diagnostics: in two volumes. Minsk: Belarus. V.1.; 495 p.
  • 2. Kamyshnikov V.S. (2000). Reference book on clinical-biochemical laboratory diagnostics: in two volumes. Minsk: Belarus. V.1.; 463 p.
  • 3. Kilham C. The herbal future. C. Kilham. Nutraceuticals world. 20, 7-8, 68-72, 2004.
  • 4. Kim H. Anti-inflammatory plant flavonoids and cellular action mechanisms. H. Kim, K. H. Son, H. W. Chang et al. Journal of pharmacological sciences. 96, 3, 229-245, 2004.
  • 5. Kobzar A.Y. (2007). Pharmacognosy in medicine. Educational manual. Кyiv: Medicine.; 544 p.
  • 6. Masevich Ts.G., Sitkin S.I.: Chronic hepatitis. Tactics of treatment depending on etiology. Aqua Vitae., 23-26, 2000.
  • 7. Mayer K.P. (2000). Hepatitis and consequences of hepatitis: practical guidance. Translation from German; edited by A.A.Sheptulin. Мoscow: Geotar Medicine.; P.157-310.
  • 8. Rybolovlev Yu.R., Rybolovlev R.S. Dosage of substances for mammals by the constants of biological activity. Reports of AS USSR 9. V. 247, No 6, P. 1513-1516, 1979.
  • 9. Stefanov O.V. (2001). Preclinical examinations of medical means (methodical recommendations): Kyiv: Avicenna; 528 p.
  • 10. Stenton G. (1999). Medical-biological statistics: Мoscow: Practice; 459 p.
  • 11. Yakovleva L.V., Gladkova L.V., Tomashevska Yu.O. Examination of membrane stabilizing action of “Phytovenol” capsules on the pattern of spontaneous hemolysis of erythrocytes. 4th National Congress “The Man and Medicines of Ukraine”, 134-135, 2001.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0024
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