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2014 | 27 | 4 | 224-228
Tytuł artykułu

Physical properties and caffeine release from creams prepared with different oils

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coconut oil, Sweet almond oil and Jojoba oil), containing 5% of caffeine, and compared the release of the substance from the obtained preparations. Initially, all of the creams were subjected to a variety of physical tests, among these being for slippage and spreadability. Furthermore, their rheological properties were evaluated. Subsequently, the creams were tested for caffeine release. In the slippage and spreadability tests, the coconut oil-based cream was revealed as having the best parameters. However, the rheological tests showed that all of the preparations had the pseudoplastic character of flowing according to the Ostwald de Waele power law model. The power low index (n) for all the preparations was from 0.2467-0.3179 at 20°C and 0.2821-0.3754 at 32°C. At 20°C, the Sesame oil-, Walnut oil-, Sweet almond oil- and Jojoba oil-based creams were thixotropic, but at 32°C, thixotropy appeared only in the Walnut oil-based creams. The release studies, conducted by way of an extracting chamber (according to Polish Pharmacoeia IX) in the Paddle Apparatus (according to Polish Pharamcopoeia IX), showed that the amount of released caffeine is the largest in the case of Jojoba oil-based cream, at 85.23% ± 0.8% (SD), and the least in the case of Coconut oil-based cream, at 62,78%± 0.87% (SD).
Słowa kluczowe
Wydawca

Rocznik
Tom
27
Numer
4
Strony
224-228
Opis fizyczny
Daty
wydano
2014-12-01
otrzymano
2014-10-15
zaakceptowano
2014-11-24
online
2015-03-03
Twórcy
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland, kgierucka@wp.pl
autor
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
autor
  • Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Bibliografia
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  • 5. Bertin et al.: A double blind evaluation of activity of an anticellulite product containing retinol, caffeine and ruscogenine by a combination of several non invasive methods. J. Cosmet. Sci. 52, 199-210, 2001.
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  • 12. Jimenez-Soriano M.M., Fresno- Contreras M.J., Selles F.: Development of a cream from a self-emulsifying base and moisturizing actives. II Farmaco, 2001, 56, 513-522.
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  • 14. Krówczyński L.: Technologia postaci leków PZWL, Warszawa, 1969.
  • 15. Omar L. et al.: Evaluation of the effects of caffeine in the microcirculation and edema on thighs and buttocks using the orthogonal polarization spectral imaging and clinical parameters. J. Cosmet. Dermatol. 6, 102-107, 2007.
  • 16. Oyedeji F., Okeke I.: Comparative analysis of moisturizing creams from vegetable oils and paraffin oil. J. App. Sci., 5, 157-160, 2010.
  • 17. Polish Pharmacopea IX, Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Bójczych. Warszawa 2011.
  • 18. Farmakopea Polska VI, PZWL, 2002
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  • 21. Wendel O.W.: Jojoba - promising liquid cosmetic wax. Cosmet and Toilet. 95, 41-54, 1980.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0020
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