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2014 | 27 | 3 | 159-164
Tytuł artykułu

Association between concentration of melatonin, and lipoproteins, LPO, hsCRP, NTproBNP in chronic heart failure patients

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the study was to examine concentrations and relationships between melatonin levels assessed at 0:200 hrs and 0:700 hrs, lipid hydroperoxide (LPO) assessed at 0:200 hrs and 0:700 hrs, and apolipoprotein (apo)AI, apoAII, apoB, high sensitivity C-reactive protein (hsCRP) and NT-proBNP, in 27 patients with chronic heart failure (CHF) (17 patients - with NYHA class II and 10 - with NYHA class III). In the study, Lipoproteins apoAI, apoAII, apoB, high sensitivity C-reactive protein (hsCRP) levels were determined by way of immunonephelometric methods, serum melatonin concentration was measured by using a competitive enzyme immunoassay technique, while serum LPO concentration was measured by using Cayman’s Lipid Hydroperoxide Assay Kit. In the study, CHF patients without acute inflammatory response demonstrated a decreased concentration of high density lipoprotein cholesterol (HDL-C), apoAI, apoAII levels, but an increased concentration of NT-proBNP, hsCRP and LPO at night, and LPO at daytime; however, the concentration of LPO at 0:700 was lower than at 0:200. Pearson’s correlation test and multiple ridge stepwise regression showed that melatonin administered at night exerts an effect on the composition of apoAI and apoAII of HDL particles, and induces decreased LPO at 0:700, but has no effect upon NT-proBNP levels in patients with NYHA class II. However, in patients with NYHA class III, melatonin administered at night induces an increase in the content of apoAII and apoAI, which further decreases hsCRP, and this, together with the administered melatonin, brings about daytime decreases in NT-proBNP and hsCRP levels. The results indicated that the content of apoAII and apoAI in HDL particles and melatonin demonstrate an anti-oxidative and anti-inflammatory effect, and together, have a cardio-protective effect on patients with advanced CHF. Hence, the results support melatonin being a cardio-protective agent. These relationships, however, need to be confirmed in further studies.
Wydawca

Rocznik
Tom
27
Numer
3
Strony
159-164
Opis fizyczny
Daty
wydano
2014-09-01
otrzymano
2014-10-23
zaakceptowano
2014-11-04
online
2015-03-03
Twórcy
  • Department of Laboratory Diagnostics, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland, elzbieta.kimak@wp.pl
  • Department of Internal Diseases, Medical University of Lublin
autor
  • Department of Laboratory Diagnostics, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Department of Internal Diseases, Medical University of Lublin
  • Department of Laboratory Diagnostics, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Chair and Department of Conservative Dentistry with Endodontics, Medical University of Lublin
  • Department of Laboratory Diagnostics, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Department of Laboratory Diagnostics, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Department of Laboratory Diagnostics, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Bibliografia
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  • 2. Berrougui H., Claudia N. Momo CN., Khalil A.: Health benefits of high-density lipoproteins in preventing cardiovascular diseases. J. Clin. Lipidol. 6, 524, 2012.[Crossref][WoS]
  • 3. Birjmohun R.S., Dallinga-Thie G.M., Kuivenhoven J.A., et al.: Apolipoprotein A-II is inversely associated with risk of future coronary artery disease. Circulation, 116, 2029, 2007.[WoS]
  • 4. Dominguez-Rodriguez A.: Melatonin in cardiovascular disease. Expert. Opin. Investig., 21, 1593, 2012.[Crossref]
  • 5. Dominguez-Rodriguez A., Abreu-Gonzalez P., Avanzas P.: The role of melatonin in acute myocardial infarction. Front. Biosci., 17, 2433, 2012.[WoS][Crossref]
  • 6. Dzida G., Prystupa A., Lachowska-Kotowska P., Kardas T., Kamieński P., Kimak E., Hałabiś M., Kiciński P.: Alteration in diurnal and nocturnal melatonin serum level in patients with chronic heart failure. AAEM., 20, 745, 2013.
  • 7. Espino J., Pariente JA., Rodriguez A.B.: Oxidative stress and immunosenescence: therapeutic effects of melatonin. Oxidative Med. Cell. Longev., 2012, 6702941, 9p, 2012.[WoS]
  • 8. Friedewald W.T., Levy R.I., Friedrickson D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin. Chem., 18, 499, 1972.
  • 9. Gauthamadasa K., Vaitinadin N.S., Dressman J.L., Macha S., Homan R., Greis K.D., Silva G.D.: Apolipoprotein AII-mediated conformation changes of apolipoprotein AI in discoidal high density lipoproteins. J. Biol. Chem., 287, 7615, 2012.
  • 10. Kimak E., Bylina J., Solski J., Hałabiś M., Baranowicz-Gąszczyk I., Książek A. Association between lipids, lipoproteins composition of HDL particles and triglyceride-rich lipoproteins, and LCAT and CETP activity in post-renal transplant patients. CBB., 67, 695, 2013.[WoS]
  • 11. Kimak E., Hałabiś M., Baranowicz-Gąszczyk I., Solski J., Książek A.: Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients. JZUS-B., 12, 365, 2011.[WoS]
  • 12. Korkmaz A., Reiter R.J., Topal T., Manchester L.C., Oter S., Tan D.X.: Melatonin, an established antioxidant worthy of use in clinical trials. Mol. Med., 15, 43, 2009.[WoS]
  • 13. Maiga S.F., Kalopissis A-D., Chabert M.: Apolipoprotein AII is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes. Biochimie., 96, 56, 2014.[Crossref]
  • 14. Marchetti C., Sidahmed-Adrar N., Collin F., Jore D., Garde`s-Albert M., Bonnefont-Rousselot D.: Melatonin protects PLPC liposomes and LDL towards radical-induced oxidation. J. Pineal. Res., 51, 286, 2011.[WoS][Crossref]
  • 15. Morceli G., Honorio-Franca A.C., Fagundes D.L., Calderon I.M., Franca E.L.: Antioxidant effect of melatonin on the functional activity of colostral phagocytes in diabetic women. PloSOne 8, e56915. Epub 2013.[WoS]
  • 16. Mozaffari S., Hasani-Ranjbar S., Abdollahi M.: The mechanisms of positive effects of melatonin in dyslipidemia: a systemic review of animal and human studies. Int. J. Pharmacol., 8, 496, 2012.[Crossref]
  • 17. Ng T.W.K., Chan D.C., Hugh P., Barrett R., Watts G.F.: Effect of weight loss on HDL-apoAII kinetics in the metabolic syndrome. Clin. Sci., 118, 79, 2010.[Crossref]
  • 18. Papaharlambus C.A , Griendling K.K.: Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury. Trends Cardiovasc. Med., 17, 48, 2007.
  • 19. Podrez E. A.: Anti-oxidant properties of high-density lipoprotein and atherosclerosis. Clin. Exp. Pharmacol. Physiol., 37, 719, 2010.[WoS][Crossref]
  • 20. Reiter R. J., Tan D-X., Paredes S.D.: Beneficial effects of melatonin in cardiovascular disease. Ann. Med., 42, 276, 2010.[Crossref][WoS]
  • 21. Shuhei N., Söderlund S., Jauhiainen M., Taskinen M-R.: Effect of HDL composition and particle size on the resistance of HDL to the oxidation. Lipid Health Dis., 9, 104, 2010.
  • 22. Tamura H., Nakamura Y., Narimatsu A., Yamagata Y., Takasaki A., Reiter R.J.: Melatonin treatment in peri- and postmenopausal women elevates serum high density lipoprotein cholesterol levels without influencing total cholesterol levels. J. Pineal. Res., 45, 101, 2008.[WoS][Crossref]
  • 23. Wakatsuki A., Okatani Y., Ikenoue N., Shinohara K., Watanabe K., Fukaya T.: Melatonin protects against oxidized low-density lipoprotein-induced inhibition of nitric oxide production in human umbilical artery. J. Pineal Res., 3,: 281, 2001.[Crossref]
  • 24. Wu W.S., Chou M.T., Chao C.M., Chang C.K., Lin M.T., Chang C.P.: Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. Acta Pharmacol. Sin., 33, 775, 2012. [Crossref][WoS]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0007
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