Supercritical carbon dioxide hops extracts with antimicrobial properties

• Autorzy: Edward Rój , Vanja M. Tadić , Dušan Mišić , Irena Žižović , Ivana Arsić , Agnieszka Dobrzyńska-Inger , Dorota Kostrzewa
• Języki publikacji: EN

Abstrakty

EN

Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 μg mL-1. Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic application in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of α-acids, β-acids, iso-α-acids and xanthohumol in the samples were determined by HPLC.

EN

Słowa kluczowe

EN

supercritical hops extract; isomerized hops extract; supercritical CO2 extraction; xanthohumol; antibacterial activity

• Czasopismo: Open Chemistry
• Rocznik: 2015
• Tom: 13
• Numer: 1

Daty

otrzymano

2015-02-23

zaakceptowano

2015-07-27

online

2015-09-11

Twórcy

autor

Edward Rój

• New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland

autor

Vanja M. Tadić

• Institute for Medicinal Plant Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11000 Belgrade, Serbia

autor

Dušan Mišić

• University of Belgrade, Faculty of Veterinary Medicine, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia

autor

Irena Žižović

• University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia

autor

Ivana Arsić

• University of Niš, Faculty of Medicine, Dr Zoran Djindjić 81, 18000 Niš, Serbia

autor

Agnieszka Dobrzyńska-Inger

• New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland

autor

Dorota Kostrzewa

• New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland

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Identyfikatory

DOI

10.1515/chem-2015-0131