Retention, separation selectivity and system efficiency of selected basic psychotropic drugs on different RPLC columns

• Autorzy: Anna Petruczynik , Karol Wróblewski , Kamil Dzioba , Monika Waksmundzka-Hajnos
• Języki publikacji: EN

Abstrakty

EN

Retention parameters of psychotropic drug standards were determined on different columns, i.e., Octadecyl silica, Phenyl, Phenyl-Hexyl, Polar Reverse Phase, Pentafluorophenyl, and Cyanopropyl using aqueous eluent systems containing methanol or acetonitrile as organic modifiers, acetate buffer at pH 3.5 and addition of silanol blocker − diethylamine (DEA). The retention, separation selectivity, and sequence of elution were different when using eluents containing various organic modifiers. The significant differences were observed in retention parameters with a change of the used stationary phase. The various properties of stationary phases resulted in differences in analyte retention, peaks shape, systems efficiency and separation selectivity. The best shape of peaks were on Cyanopropyl (CN) column and the highest efficiency for most investigated psychotropic drugs were obtained on Phenyl-Hexyl and Polar RP columns.

EN

Słowa kluczowe

EN

HPLC; psychotropic drugs; silanol blockers; different stationary phases; system efficiency

• Czasopismo: Open Chemistry
• Rocznik: 2015
• Tom: 13
• Numer: 1

Daty

otrzymano

2014-12-12

zaakceptowano

2015-04-01

online

2015-06-03

Twórcy

autor

Anna Petruczynik

• Department of Inorganic Chemistry Medical University
  of Lublin,Chodźki 4a, 20-093 Lublin, Poland

autor

Karol Wróblewski

• Department of Inorganic Chemistry Medical University
  of Lublin,Chodźki 4a, 20-093 Lublin, Poland

autor

Kamil Dzioba

• Department of Inorganic Chemistry Medical University
  of Lublin,Chodźki 4a, 20-093 Lublin, Poland

autor

Monika Waksmundzka-Hajnos

• Department of Inorganic Chemistry Medical University
  of Lublin,Chodźki 4a, 20-093 Lublin, Poland

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Identyfikatory

DOI

10.1515/chem-2015-0106