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2015 | 13 | 1 |
Tytuł artykułu

Centaurea cyanusL. Polysaccharides and Polyphenols Cooperation in Achieving Strong Rat Gastric Ulcer Protection

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
This work was aimed at testing gastroprotective effects of Centaurea cyanus L. (herba) polysaccharides (P) and polyphenols (A) fractions on stress-induced rat ulcer model. Studies evaluating acute toxicity in rats and antioxidant (chemiluminescence method) and antimicrobial (on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains) activities of Centaurea cyanus L. (herba) product, which combined polysaccharides and polyphenols fractions (PA), have also been done. Accordingly, in vivo pharmacological studies revealed high influence of PA product (500 mg kg-1 of body weight) on deep, moderate and superficial gastric mucosal lesions, greater than that of chemical reference, Ranitidine. P product was proven more effective than Ranitidine in opposing the emergence of deep necrotic lesions only, suggesting the ability of polysaccharides compounds to consolidate gastric mucous layer as well as their certain tendency for cooperation with polyphenols fractions. The acute toxicity study indicated the lack of toxicity of PA product and maximum tolerated doses greater than 1875 mg kg-1 of body weight. PA product provided augmented scavenger activity and week antimicrobial activity on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains, resulting in better opportunities for valorisation of the aerial part of Centaurea cyanus L. species in order to obtain new and effective natural medicines.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
13
Numer
1
Opis fizyczny
Daty
otrzymano
2014-12-17
zaakceptowano
2015-03-01
online
2015-05-26
Twórcy
autor
  • National Institute for Chemical-
    Pharmaceutical Research and Development (ICCF), Vitan 112,
    Sector 3, Bucharest, Romania
  • National Institute for Chemical-
    Pharmaceutical Research and Development (ICCF), Vitan 112,
    Sector 3, Bucharest, Romania
  • National Institute for Chemical-
    Pharmaceutical Research and Development (ICCF), Vitan 112,
    Sector 3, Bucharest, Romania
autor
  • OVIDIUS University – Constanta,
    Mamaia 124, Constanta, Romania
  • OVIDIUS University – Constanta,
    Mamaia 124, Constanta, Romania
  • Academy of Romanian Scientists, Splaiul
    Independentei 54, Bucharest, Romania
Bibliografia
  • [1] de Kok T.M., van Breda S.G., Manson M.M., Mechanismsof combined action of different chemopreventive dietarycompounds: a review, Eur. J. Of Nutrition, 2008, 47, 51-9.
  • [2] U.S. Department of Health and Human Services, http://www.niddk.nih.gov/health-information/health-statistics.
  • [3] Pirvu L., Coprean D., Schiopu S., Colceru S., Vegetal extractswith gastroprotective activity. Part. I. Extracts obtained fromCentaurea cyanus L. raw material, Romanian BiotechnologicalLetters, 2012, 17, 7169-7176.
  • [4] Action plan for Centaurea cyanus, http://www.ukbap.org.uk/UKPlans.aspx?ID=198.
  • [5] Alec Vonica G. D., Identifying and evaluating ornamentalpotential of some Centaurea species from Transylvaniaspontaneous flora with the purpose of complimenting thecultivated assortment, PhD thesis, University of AgricultureScience and Veterinary Medicine Cluj-Napoca, Romania, 2013,http://www.usamvcluj.ro/files/teze/2013/alec.pdf.
  • [6] Monya, K., Sabau, M., Racz G., Antibiotic effect of extracts fromCentaurea, Planta Medica, 1968, 16, 58.[Crossref]
  • [7] Alexan M., Bojor F., Craciun F., Romanian phytomedicines,Ceres, Bucharest, 1988, (in Romanian).
  • [8] Pirvu C., Plant Universe, Enciclopedica, Bucharest, 1997, (inRomanian).
  • [9] Garbacki N., Gloaguen V., Damas J., Bodart P., Tits M., AngenotL., Anti-inflammatory and immunological effects of Centaureacyanus flower-heads, J. Ethnopharmacol., 1999, 68, 235-241.[Crossref]
  • [10] Litvinenko V.I., Bubenchikova V.N., Phytochemical study ofCentaurea cyanus, Chemistry of Natural Compounds, 1988, 24,672-674.
  • [11] Murav’eva D.A., Bubenchikova V.N., Phenolcarboxylic acidsof the flowers of Centaurea cyanus, Chemistry of NaturalCompounds, 2007, 22, 102.
  • [12] Wagner H., Bladt S., Plant Drug Analysis, 2nd ed., Springer,Berlin, 1996.
  • [13] Reich E., Schibli A., HPTLC for the Analysis of Medicinal Plants,Thieme, N.Y.- Stuttgart, 2008.
  • [14] Romanian Pharmacopoeia, 10th ed., Medicala, Bucharest, 1993,(in Romanian).
  • [15] Iftimie N., Giurginca M., Meghea A., Oxidative stressquantification in biosystems (in Romanian)”, Rev. Chim.Bucharest, 2004, 55, 359 – 362.
  • [16] Ramesh B., Pugalendi K.V., Antioxidant role of Umbelliferone inSTZ-diabetic rats, Life Sci., 2006, 79, 306-10.[Crossref]
  • [17] Rajbir S., Bikram S., Sukhpreet S., Neeraj K., Subodh K., Saroj A.,Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats, Food Chemistry,2010, 120, 825-34.
  • [18] Revathi R., Manju V., Effects of Umbelliferone on lipidperoxidation and antioxidant status in diethylnitrosamineinduced hepatocellular carcinoma, Journal of Acute Medicine,2013, 3, 73-82.
  • [19] John-Africa L.B., Yahaya T.A., Isimi C.Y., Anti-ulcer and woundhealing activities of Sida corymbosa in rats, Afr J TraditComplement Altern Med., 2013, 11, 87-92.
  • [20] Monforte M.T., Lanuzza F., Pergolizzi S., Mondello F., Tzakou O.,Galati E.M., Protective effect of Calamintha officinalis Moenchleaves against alcohol-induced gastric mucosa injury in rats.Macroscopic, histologic and phytochemical analysis, PhytotherRes., 2012, 26, 839-44.[Crossref]
  • [21] Borrelli F., Izzo A.A., The plant kingdom as a source of anti-ulcerremedies, Phytother Res., 2000, 14, 581-91.[Crossref]
  • [22] Alarcón de la Lastra C., Martín M.J., Motilva V., Antiulcer andgastroprotective effects of quercetin: a gross and histologicstudy, Pharmacology, 1994, 48, 56-62.[Crossref]
  • [23] Martín M.J. La-Casa C., Alarcón de la Lastra C., Cabeza J.,Villegas I., Motilva V., Anti-oxidant mechanisms involved ingastroprotective effects of quercetin, Z Naturforsch C., 1988, 53,82-8.
  • [24] Parmar N.S., The gastric anti-ulcer activity of naringenin, aspecific histidine decarboxylase inhibitor, Int J Tissue React.,1983, 5, 415-20.
  • [25] Martín M.J., Marhuenda E., Pérez-Guerrero C., Franco J.M.,Antiulcer effect of naringin on gastric lesions induced by ethanolin rats, Pharmacology, 1994, 49, 144-50.[Crossref]
  • [26] Motilva V., Alarcón de la Lastra C., Martín M.J., Effects ofnaringenin on gastric lesions induced by ethanol in rat: roleof endogenous prostaglandins, J Pharm Pharmacol., 1994, 46,91-94.[Crossref]
  • [27] Parmar N.S., Ghosh M.N., Gastric anti-ulcer activity of (+)cyanidanol-3, a histidine decarboxylase inhibitor, Eur JPharmacol., 1981, 69, 25-32.
  • [28] Reyes M., Martín C., Alarcón de la Lastra C., Lastra C., Trujillo J.,Toro M.V., et al., Antiulcerogenicity of the flavonoid fraction fromErica andevalensis Cabezudo-Rivera, Z Naturforsch C., 1996, 51,563-9.
  • [29] Fraisse D., Felgines C., Texier O., Lamaison J.L., CaffeoylDerivatives: Major Antioxidant Compounds of Some Wild Herbsof the Asteraceae Family, Food and Nutrition Sciences, 2011, 2,181-192.
  • [30] Schmidgall J., Schnetz E., Hensel A., Evidence for bioadhesiveeffects of polysaccharides and polysaccharide-containing herbsin an ex vivo bioadhesion assay on buccal membranes, PlantaMed., 2000, 66, 48-53.[Crossref]
  • [31] Kasinadhuni V.R.R, Rajashekhar G., Anti-ulcer potential ofHaldinia cordifolia, Fitoterapia, 1999, 70, 93-95.[Crossref]
  • [32] Suvitayavat W., Sumrongkit, C., Thirawarapan S.S.,Bunyapraphatsara N., Effects of Aloe preparation on thehistamine-induced gastric secretion in rats, J. Ethnopharmacol,2004, 90, 239-247.[Crossref]
  • [33] Sun X.B., Matsumoto T., Cytoprotective activity of pecticpolysaccharides from the root of panax ginseng, J.Ethnopharmacol., 1991, 31, 101-7.[Crossref]
  • [34] Sun X.B., Matsumoto T., Yamada H., Anti-ulcer activity andmode of action of the polysaccharides fraction from the leavesof Panax ginseng, Planta Med., 1992, 58, 432-5.[Crossref]
  • [35] Nascimento A.M., de Souza L.M., Baggio C.H., Werner M.F.,Maria-Ferreira D., da Silva L.M., et al., Gastroprotective effectand structure of a rhamnogalacturonan from Acmella oleracea,Phytochemistry, 2013, 85, 137-42.[Crossref]
  • [36] Maria-Ferreira D., da Silva L.M., Mendes D.A.G.B., deAlmeida Cabrini D., Nascimento A.M., Iacomini M., et al.,Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen:Gastroprotective and Ulcer Healing Properties in Rats, PLoSONE, 2014, 9: e84762. doi:10.1371/journal.pone.0084762A.
  • [37] Yamada H., Sun X.B., Matsumoto T., Purification of anti-ulcerpolysaccharides from the roots of Bupleurum falcatum, PlantaMed., 1991, 57, 555-9.[Crossref]
  • [38] Matsumoto T., Moringuchi R., Yamada H., Role ofpolymorphonuclear leucocytes and oxygen-derived free radicalsin the formation of gastric lesions induced by HCl/ethanol, and apossible mechanism of protection by anti-ulcer polysaccharide,J. Pharmacol., 1993, 45, 535-9.
  • [39] Kameoka S., Leavitt P., Chang C., Kuo S.M., Expression ofantioxidant proteins in human intestinal Caco-2 cells treatedwith dietary flavonoids, Cancer Lett., 1999, 146, 161-7.[Crossref]
  • [40] Aboobaker V.S., Balgi A.D., Bhattacharya R.K., In vivo effect ofdietary factors on the molecular action of aflatoxin B1: role ofnon-nutrient phenolic compounds on the catalytic activity ofliver fractions, In Vivo, 1994, 8, 1095-8.
  • [41] de la Lastra A. C., Martin M.J., Motilva V., Antiulcer andgastroprotective effects of quercetin: a gross and histologicstudy, Pharmacology, 1994, 48, 56-62.[Crossref]
  • [42] Hope W.C., Welton A.F., Fielder-Nagy C., Batula-BernardoC., Coffey J.W., In vitro inhibition of the biosynthesis of slowreacting substance of anaphylaxis (SRS-A) and lipoxygenaseactivity by quercetin, Biochem, Pharmacol., 1983, 32, 367-371.
  • [43] Saija A., Scalese M., Lanza M., Flavonoids as antioxidant agents:importance of their interaction with biomembranes, Free RadicBiol Med., 1995, 19, 481-6.
  • [44] Beil W., Birkholz C., Sewing K.F., Effects of flavonoids on parietalcell acid secretion, gastric mucosal prostaglandin production and Helicobacter pylori growth, Arzneimittelforschung, 1995,45, 697-700.
  • [45] Bae E.A., Han M.J., Kim D.H., In vitro anti-Helicobacter pyloriactivity of some flavonoids and their metabolites, Planta Med.,1999, 65, 442-3.[Crossref]
  • [46] Bae E.A, Han M.J., Kim D.H., In vitro anti-Helicobacter pyloriactivity of some flavonoids and their metabolites, Planta Med.,1999, 65, 442-3.[Crossref]
  • [47] Yoshida T., Hatano T., Ito H., Chemistry and function of vegetablepolyphenols with high molecular weights, Biofactors, 2000, 13,121-5.[Crossref]
  • [48] Yanagawa Y., Yamamoto Y., Hara Y., Shimamura T., A combinationeffect of epigallocatechin gallate, a major compound of greentea catechins, with antibiotics on Helicobacter pylori growth invitro, Curr Microbiol., 2003, 47, 244-9.[Crossref]
  • [49] Yee Y.K., Koo M.W., Anti-Helicobacter pylori activity of Chinesetea: in vitro study, Aliment Pharmacol Ther., 2000, 14, 635-8.[Crossref]
  • [50] Bae E.A., Han M.J., Kim N.J., Kim D.H., Anti-Helicobacter pyloriactivity of herbal medicines, Biol Pharm Bull., 1998, 21, 990-2.[Crossref]
  • [51] Manicheva O.A., Barnaulov O.D., Effect of plant drugs on thenucleic acid content of gastric tissues during ulcerogenesis,Rastit. Resur., 1984, 20, 256-264.
  • [52] Barnaulov O.D., Manicheva O.A, Yasinov R.K., Yakovlev G.P.,Evaluation of the Effects of Flavonoids from the Aerial Parts ofAstragalus Quisqualis Bunge and A. Floccosifolius Sumn. on theDevelopment of Experiemntal Lesions in the Mouse Stomach,Rastit. Resur., 1985, 21, 85-90.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_chem-2015-0102
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