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2015 | 13 | 1 |
Tytuł artykułu

Application of QuEChERS - High Performance Liquid Chromatography with Postcolumn Fluorescence Derivatization (HPLC-FLD) method to analyze Eprinomectin B1a residues from apour-onconditioning in bovine edible tissues

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A QuEChERS in house method for determining the marker residue of eprinomectin (eprinomectin B1a) by HPLC-FLD in bovine tissues and milk provided from treated animals was developed and applied. Briefly: all samples were extracted with acetonitrile using a dispersive SPE purification stage. The ascertained detection limits were 1 μg kg-1 and the quantification limits 2 μg kg-1. Recoveries on tissue samples fortified in the range of 10 μg kg-1 to 200 μg kg-1 were from 80.0% to 87.2%, with variation coefficients between 2.7% to 10.6%. The confirmation of residues in the purified extracts was made by LC-MS/MS after separation on an XTerra MS C18 (10 cm × 2.1 mm, 3.5 μm) column with a mobile phase of acetonitrile / formic acid 0.1% (97:3, v/v) at a flow rate of 0.2 mL min-1 and MRM monitoring of three characteristic ions (m/z 896.1, m/z 467.9 and m/z 329.9), resulting from the fragmentation of molecular ions [M-H]+ (m/z 914.6) of eprinomectin and the comparison of the abundance ratio of fragmented ions was obtained in the booth, sample and standard at comparative concentrations. In conclusion, this method has proven its advantage and versatility as a routine drug residues analysis method.
EN
Wydawca
Czasopismo
Rocznik
Tom
13
Numer
1
Opis fizyczny
Daty
otrzymano
2014-10-29
zaakceptowano
2015-01-16
online
2015-02-12
Twórcy
autor
  • N.S. Pasteur Institute, Bucharest Romania
  • Banat’s University
    of Agriculture and Veterinary Medicine “King Michael I of Romania”
    from Timisoara (BUAMVT), 119, Calea Aradului, 300645, Timisoara,
    Romania. Department of Pharmacology and Pharmacy
  • Banat’s University
    of Agriculture and Veterinary Medicine “King Michael I of Romania”
    from Timisoara (BUAMVT), 119, Calea Aradului, 300645, Timisoara,
    Romania. Department of Pharmacology and Pharmacy
  • BUAMVT, Romania, Faculty of Veterinary Medicine,
    Department of Toxicology
  • BUAMVT, Romania, Faculty of Food
    Technology, Food control and expertise Dept.
  • BUAMVT, Romania, Chemistry and Biochemistry
    Depts.
autor
  • BUAMVT, Romania, Faculty of Food
    Technology, Food control and expertise Dept.
Bibliografia
  • [1] Inchem WHO Food Additives Series 41: eprinomectin.,The 50th meeting of the Joint FAO/WHO Expert Committee onFood Additives (JECFA) Geneva, 1998, http://www.inchem.org/documents/jecfa/jecmono/v041je02.htm
  • [2] Wells R.G., Eprinomectin, In: Residues of Some Veterinary Drugsin Animals and Food: Monographs prepared by the FiftiethMeeting Joint FAO/WHO Expert Committee on Food Additives(JECFA) Meeting, Rome, 17-26 February 1998, 41, 31, 1999,http://books.google.ro/books?id=jMCHWPfDYf4C&printsec=frontcover&hl=ro&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
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  • [4] EMEA/MRL/114/96 Final, Eprinomectin – Summary Report,http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500014177.pdf
  • [5] Commission Regulation (EU) No 37/2010 on pharmacologicallyactive substances and their classification regarding maximumresidue limits in foodstuffs of animal origin, http://ec.europa.eu/health/files/mrl/mrl_20101212_consol.pdf
  • [6] Shoop W., Soll M., Ivermectin, abamectin and eprinomectin,In: J. Vercruysse and R.S. Rew, (Eds.), Macrocyclic lactones inantiparasitic therapy, CABI Publishing, Oxon, U.K., 2002.
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  • [25] Directive 2004/9/EC of the European parliament and of theCouncil of 11 February 2004 on the inspection and verification ofgood laboratory practice (GLP), http://ec.europa.eu/enterprise/sectors/chemicals/documents/specific-chemicals/laboratorypractice/index_en.htm
  • [26] Directive 2004/10/EC of the European parliament and of theCouncil of 11 February 2004 on the harmonisation of laws,regulations and administrative provisions relating to theapplication of the principles of good laboratory practice and theverification of their applications for tests on chemical substances,http://ec.europa.eu/enterprise/sectors/chemicals/documents/specific-chemicals/laboratory-practice/index_en.htm
  • [27] Commission Decision 2002/657/EC implementing CouncilDirective 96/23/EC concerning the performance of analyticalmethods and the interpretation of results.
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  • [31] Ordin nr. 187 din 31 octombrie 2007, pentru aprobarea Normeisanitare veterinare privind Codul produselor medicinaleveterinare (In Romanian), 2007, http://www.ansvsa.ro/documente/Ordin_187_2007_Codul_produselor_medicinale_veterinare_262ro.pdf
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_chem-2015-0097
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