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2015 | 13 | 1 |
Tytuł artykułu

Non-thermal plasma treatment induces MAPK signaling in human monocytes

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.
EN
Wydawca
Czasopismo
Rocznik
Tom
13
Numer
1
Opis fizyczny
Daty
otrzymano
2014-01-07
zaakceptowano
2014-06-24
online
2014-12-30
Twórcy
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
autor
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
  • Institute for Medical Biochemistry and Molecular
    Biology, University of Greifswald, Ferdinand-Sauerbruch-Straße /
    Klinikum DZ 7, 17489 Greifswald, Germany
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
autor
  • Leibniz Institute
    for Plasma Science and Technology (INP Greifswald e.V.), Felix-
    Hausdorff-Str. 2, 17489 Greifswald, Germany
  • Institute of Pharmacy, Department of
    Pharmaceutical Biology, University of Greifswald, Friedrich-Ludwig-
    Jahn-Str. 17, 17489 Greifswald, Germany
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_chem-2015-0071
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