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2015 | 13 | 1 |
Tytuł artykułu

The influence of Ki-67 proliferation index on Tc-99m-EDDA-HYNIC-TOC somatostatin receptor scintigraphy in patients with carcinoids

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of this paper is to determine the influence of Ki-67 proliferation index on somatostatin receptor scintigraphy (SSRS) with Tc-99m-EDDA-HYNIC-TOC (Tc-99m-Tektrotyd) somatostatin analogue in patients with carcinoid tumors. Sixty-one patients (31 female, 30 male; age range: 33-76 years) were examined: 13 patients highly suspected of having a carcinoid, and 48 patients who had undergone the surgical removal of the tumor. Whole body SSRS at 4 h postinjection, spot scintigrams and SPECT of the selected regions were obtained for all patients. Tc-99m-Tektrotyd scintigraphy was classified as true positive in 26 out of 30 and true negative in 24 out of 28 patients. The sensitivity of Tc-99mTc-Tektrotyd scintigraphy was found to be as high as 94.74% in the group of patients with low mitotic index Ki67 (<2%), and it progressively decreased in patients with higher mitotic index (77.78% for Ki67 2-15% and 20% for Ki67% >20%). The likelihood of Tc-99m-Tektrotyd scan being positive when a carcinoid is present was found to be inversely proportional to the value of Ki67 proliferation index. The results showed that Tc-99m-Tektrotyd SSRS is a sensitive method for diagnosing and staging patients with well-differentiated carcinoid tumors. However, in poorly differentiated tumors with high Ki67 proliferation index, additional analyses are necessary for precise staging.
Wydawca

Czasopismo
Rocznik
Tom
13
Numer
1
Opis fizyczny
Daty
otrzymano
2014-02-28
zaakceptowano
2014-06-30
online
2014-11-26
Twórcy
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Niš, 18000 Niš, Serbia
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Niš, 18000 Niš, Serbia
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Niš, 18000 Niš, Serbia
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Niš, 18000 Niš, Serbia
autor
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Niš, 18000 Niš, Serbia
  • Faculty of Medicine, Clinic of Physical Medicine, Rehabilitation and Prosthetics, Clinical Center Niš, 18000 Niš, Serbia
  • Faculty of Medicine, Clinic for Surgery, Clinical Center Niš, 18000 Niš, Serbia
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Kragujevac, 34000 Kragujevac, Serbia
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_chem-2015-0042
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