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Tytuł artykułu

N-cadherin in cancer dormancy

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
N-cadherin is an adhesion protein, which is important for intercellular interaction. It is involved in cell migration and motility during embryonic development, neuronal synapsis and cancer metastasis. There are several signaling cascades affected by N-cadherin including TGF-β, Rho family. N-cadherin is associated at the cytoplasmic domain with catenins (α, β, γ and p120) to facilitate metastasis. An increase in N-cadherin with down regulation of E-cadherin occurs during epithelial mesenchymal transition. Overexpression of N-cadherin is associated with cell cycle arrest, which correlates with a similar property of cancer stem cells (CSC). Connexin expression, which is important in CSC dormancy, is regulated by N-cadherin. This review discusses the potential of N-cadherin to be involved in maintaining CSCs, and to investigate pathways in N-cadherin expression. A better understanding of the role of N-Cadherin in CSC biology may identify new targets for the treatment of cancer.
Wydawca

Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2015-04-24
zaakceptowano
2015-06-15
online
2015-08-10
Twórcy
autor
  • Dept. of Medicine, Hematology/Oncology, New Jersey
    Medicine School, Rutgers University, Newark, NJ, USA
  • Graduate School of Biomedical
    Science, Rutgers University, Newark, NJ, USA
  • Dept. of Medicine, Hematology/Oncology, New Jersey
    Medicine School, Rutgers University, Newark, NJ, USA
  • Graduate School of Biomedical
    Science, Rutgers University, Newark, NJ, USA
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_cdth-2015-0002
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