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Computational Tools Applied to Enzyme Design − a review

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The protein design toolbox has been greatly improved by the addition of enzyme computational simulations. Not only do they warrant a more ambitious and thorough exploration of sequence space, but a much higher number of variants and protein-ligand systems can be analyzed in silico compared to experimental engineering methods. Modern computational tools are being used to redesign and also for de novo generation of enzymes. These approaches are contingent on a deep understanding of the reaction mechanism and the enzyme’s three-dimensional structure coordinates, but the wealth of information produced by these analyses leads to greatly improved or even totally new types of catalysis.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2015-08-11
zaakceptowano
2015-11-10
online
2016-02-02
Twórcy
  • Departamento
    de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología,
    Universidad Nacional Autónoma de México, Av. Universidad
    2001, Col. Chamilpa, CP 62210, Cuernavaca, Morelos, México
autor
  • Departamento
    de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología,
    Universidad Nacional Autónoma de México, Av. Universidad
    2001, Col. Chamilpa, CP 62210, Cuernavaca, Morelos, México
  • Departamento
    de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología,
    Universidad Nacional Autónoma de México, Av. Universidad
    2001, Col. Chamilpa, CP 62210, Cuernavaca, Morelos, México
  • Departamento
    de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología,
    Universidad Nacional Autónoma de México, Av. Universidad
    2001, Col. Chamilpa, CP 62210, Cuernavaca, Morelos, México
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_boca-2015-0009
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