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Short Peptides in Minimalistic Biocatalyst Design

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We review recent developments in the use of short peptides in the design of minimalistic biocatalysts focusing on ester hydrolysis. A number of designed peptide nanostructures are shown to have (modest) catalytic activity. Five features are discussed and illustrated by literature examples, including primary peptide sequence, nanosurfaces/scaffolds, binding pockets, multivalency and the presence of metal ions. Some of these are derived from natural enzymes, but others, such as multivalency of active sites on designed nanofibers, may give rise to new features not found in natural enzymes. Remarkably, it is shown that each of these design features give rise to similar rate enhancements in ester hydrolysis. Overall, there has been significant progress in the development of fundamental understanding of the factors that influence binding and activity in recent years, holding promise for increasingly rational design of peptide based biocatalysts.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
1
Opis fizyczny
Daty
otrzymano
2015-05-15
zaakceptowano
2015-08-05
online
2015-09-01
Twórcy
  • WestCHEM/Department of Pure
    and Applied Chemistry, University of Strathclyde, Thomas Graham
    Building, 295 Cathedral Street, Glasgow, G1 1XL, UK
  • WestCHEM/Department of Pure
    and Applied Chemistry, University of Strathclyde, Thomas Graham
    Building, 295 Cathedral Street, Glasgow, G1 1XL, UK
  • Advanced Science Research
    Center (ASRC) and Hunter College, City University of New York, 85 St
    Nicholas Terrace, New York, NY10031, USA
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_boca-2015-0005
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