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2016 | 3 | 1 |
Tytuł artykułu

Differences in basal DNA damage in blood cells from men and women

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We have recently shown that inhabitants of two polluted areas in Kosovo display more DNA damage (strand breaks in blood cell DNA) than do residents of a cleaner area. Here, we present additional analyses of these data and discuss additional data sets from Kosovo. Based on our data as well as the available data from other authors, age and sex-related differences in DNA damage or in susceptibility to DNA-damaging agents in the environment should be carefully considered when designing biomonitoring studies and when carrying out statistical analysis of the data.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
3
Numer
1
Opis fizyczny
Daty
otrzymano
2016-02-04
zaakceptowano
2016-02-22
online
2016-03-17
Twórcy
  • Department of Biology, University
    of Prishtina, Xhorxh Bush, n.n.,10000, Prishtina, Kosovo
  • Department of Nutrition, Institute of Basic
    Medical Sciences, University of Oslo, PB 1046 Blindern, 0316 Oslo,
    Norway.
  • Faculty of Medicine, University of Prishtina,
    Xhorxh Bush Street, n.n.,10000, Prishtina, Kosovo
  • Department of Biology, University
    of Prishtina, Xhorxh Bush, n.n.,10000, Prishtina, Kosovo
  • Department of Biology, University
    of Prishtina, Xhorxh Bush, n.n.,10000, Prishtina, Kosovo
  • Department of Cell Biology, University
    of Salzburg, Hellbrunnerstr. 34, A-5020 Salzburg, Austria
  • Department of Cell Biology, University
    of Salzburg, Hellbrunnerstr. 34, A-5020 Salzburg, Austria
Bibliografia
  • [1] Dusinska M, Collins AR: The comet assay in humanbiomonitoring: gene–environment interactions. Mutagenesis.2008; 23(3): 191-205.[WoS][Crossref]
  • [2] Collins AR, Azqueta A: Single-cell gel electrophoresis combinedwith lesion-specific enzymes to measure oxidative damage to DNA. In P.M.Conn (ed.), Laboratory Methods in Cell Biology,2012, pp. 69-92, Elsevier Inc.[WoS]
  • [3] Azqueta A, Collins AR: The essential comet assay: a comprehensiveguide to measuring DNA damage and repair. ArchToxicol. 2013; 87(6): 949-968.[WoS]
  • [4] Collins A, Koppen G, Valdiglesias V, Dusinska M, KruszewskiM, Møller P, Rojas E, Dhawan A, Benzie I, Coskun E, MorettiM, Speit G, Bonassi S, ComNet project: The comet assay as a tool for human biomonitoring studies: the ComNet project,Mutat Res Rev Mutat Res. 2014; 759: 27-39.[WoS]
  • [5] Møller P, Knudsen LE, Loft S, Wallin H: The Comet Assay asa Rapid Test in Biomonitoring Occupational Exposure toDNA-damaging Agents and Effect of Confounding Factors.Cancer Epidemiol Biomarkers Prev. 2000; 9 (10): 1005-1015.
  • [6] Faust F, Kassie, F, Knasmüller S, Boedecker RH, Mann M, Mersch-Sundermann V: The use of the alkaline comet assay withlymphocytes in human biomonitoring studies. Mutat Res.2004; 566 (3): 209–229.
  • [7] Alija AJ, Asllani F, Bajraktari ID, Collins AR, Dreshaj S, BresgenN, Eck PM: Atmospheric pollution in Kosovo is associatedwith increased DNA damage in the human population.Biomonitoring. 2015; 2 (1): 35-41.
  • [8] Møller P: Assessment of reference values for DNA damagedetected by the comet assay in human blood cell DNA. MutatRes. 2006; 612 (2): 84-104.
  • [9] Kruszewski M, Wojewódzka M, Iwanen̄ko T, Collins AR, SzumielI: Application of the comet assay for monitoring DNA damagein workers exposed to chronic low-dose irradiation: II. Basedamage. Mutat Res. 1998; 416 (1-2): 37–57.
  • [10] Pérez-Cadahía B, Méndez J, Pásaro E, Lafuente A, CabaleiroT, Laffon B: Biomonitoring of Human Exposure to Prestige Oil: Effects on DNA and Endocrine Parameters. Environ HealthInsights. 2008; 2: 83–92.
  • [11] Betti C, Davini T, Giannessi L, Loprieno N, Barale R: Microgelelectrophoresis assay (comet test) and SCE analysis in humanlymphocytes from 100 normal subjects. Mutat Res. 1994; 307(1): 323-333.
  • [12] Wojewódzka M, Kruszewski M, Iwaneñko T, Collins AR, SzumielI: Application of the comet assay for monitoring DNA damagein workers exposed to chronic low-dose irradiation. I. Strandbreakage. Mutat Res. 1998; 416 (1-2): 21-35.
  • [13] Bajpayee M, Dhawan A, Parmar P, Pandey AK, Mathur N,Seth PK: Gender-related differences in basal DNA damage inlymphocytes of a healthy Indian population using the alkalineComet assay. Mutat Res. 2002; 520 (1-2): 83–91.
  • [14] Garaj-Vrhovac V, Kopjar N: The alkaline Comet assay asbiomarker in assessment of DNA damage in medical personneloccupationally exposed to ionizing radiation. Mutagenesis.2003; 18 (3): 265–271.[Crossref]
  • [15] Zhu CQ, Lam TH, Jiang CQ, Wei BX, Lou X, Liu WW, Lao XQ, ChenYH: Lymphocyte DNA damage in cigarette factory workers measured by the Comet assay, Mutat Res., 1999; 444 (1) 1-6.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_1515_bimo-2016-0001
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