Dissolution behavior and cell compatibility of alkali-free MgO-CaO-SrO-TiO₂-P₂O₅glasses for biomedical applications

• Autorzy: Sungho Lee , Akiko Obata , Delia S. Brauer , Toshihiro Kasuga
• Języki publikacji: EN

Abstrakty

EN

Owing to their controlled solubility, phosphate invert glasses are of interest for use as temporary implant materials or tissue engineering scaffolds for controlled ion release.MgO-CaO-SrO-TiO2-P2O5 invert glasses were prepared and their dissolution behavior and cell response were examined.MgO addition to the phosphate invert glass system improved glass formation, owing to the relatively large field strength of Mg2+ ions. In osteoblastlike MC3T3-E1 cell culture tests, cell numbers on the invert glasses were significantly larger compared with the control, possibly caused by the release of Mg2+ ions promoting enhanced cell adhesion and proliferation. Alkaline phosphatase (ALP) activity varied with glass composition, with higher strontium for calcium substitution (33 to 100%) showing highest ALP activity. This effect may be caused by the release of strontium ions from the glasses.

Słowa kluczowe

EN

Phosphate glass; magnesium; calcium; strontium; ion release; cell response; MC3T3-E1

• Czasopismo: Biomedical glasses
• Rocznik: 2015
• Tom: 1
• Numer: 1

Daty

otrzymano

2015-08-04

zaakceptowano

2015-10-02

online

2015-12-18

Twórcy

autor

Sungho Lee

• Department of Frontier Materials, Graduate
  School of Engineering, Nagoya Institute of Technology, Gokisocho,
  Showa-ku, Nagoya 466-8555, Japan

autor

Akiko Obata

• Department of Frontier Materials, Graduate
  School of Engineering, Nagoya Institute of Technology, Gokisocho,
  Showa-ku, Nagoya 466-8555, Japan

autor

Delia S. Brauer

• Otto Schott Institute of Materials Research,
  Friedrich Schiller University Jena, Fraunhoferstr. 6, 07743 Jena,
  Germany

autor

Toshihiro Kasuga

• Department of Frontier Materials, Graduate
  School of Engineering, Nagoya Institute of Technology, Gokisocho,
  Showa-ku, Nagoya 466-8555, Japan

Bibliografia

• [1] Hench L.L., Polak J.M., Third-Generation Biomedical Materials,Science 2002, 295, 1014–1017
• [2] Xynos I.D., Edgar A.J., Buttery L.D.K., Hench L.L., Polak J.M.,Ionic Products of Bioactive Glass Dissolution Increase Proliferationof Human Osteoblasts and Induce Insulin-Like Growth FactorII mRNA Expression and Protein Synthesis, J. Biomed.Mater.Res. 2000, 276, 461–465
• [3] Jones J.R., Tsigkow O., Coates E.E., Stevens M.M., Polak J.M.,Hench L.L., Extracellular Matrix Formation and Mineralizationon a Phosphate-Free Porous Bioactive Glasses Scaffold UsingPrimary Human Osteoblasts (HOB) Cells, Biomaterials 2007, 28,1653–1663[WoS][Crossref]
• [4] Takeichi M., Okada T.S., Role ofMagnesiumAnd CalciumIons inCell-To-Substrate Adhesion, Exptl. Cell Res. 1972, 74, 51–60
• [5] Yamasaki Y., Yoshida Y., Okazaki M., Shimazu A., Uchida T.,Kudo T., et al., Synthesis of Functionally Graded MgCO3 ApatiteAccelerating Osteoblast Adhesion, J. Biomed. Res. 2002, 62,99–105
• [6] Wolf F.I., Cittadini A., Magnesium in Cell Proliferation and Differentiation,Front. Biosci. 1999, 4, d607–617[WoS][Crossref]
• [7] Saboori A., Rabiee M., Moztarzadeh F., Sheikhi M., Tahriri M.,Karimi M., Synthesis, Characterization and in Vitro Bioactivity ofSol-Gel-Derived SiO2-CaO-P2O5-MgO Bioglass,Mater. Sci. Eng.C 2009, 29, 335–340[Crossref]
• [8] Marie P.J., Ammann P., Boivin G., Ray C., Mechanisms of Actionand Therapeutic Potential of Strontium in Bone, Calcif. TissueInt. 2001, 69, 121–129
• [9] Marie P.J., StrontiumRanelate: A Physiological Approach for OptimizingBone Formation and Resorption, Bone 2006, 38, S10–S14[Crossref]
• [10] Marie P.J., Strontium Ranelate: New Insights into Its Dual Modeof Action, Bone 2007, 40, S5–S8[Crossref]
• [11] Kasuga T., Abe Y., Calcium Phosphate Invert Glasses with Sodaand Titania, J. Non-Cryst. Solids 1999, 243, 70–74
• [12] Kasuga T., Hosoi Y., Nogami M., Apatite Formation on CalciumPhosphate Invert Glasses in Simulated Body Fluid, J. Am. Ceram.Soc. 2001, 84, 450–452
• [13] Kasuga T., Hattori T., Niinomi M., Phosphate Glasses and Glass-Ceramics for Biomedical Applications, Phosphorus Res. Bull.2012, 26, 8–15
• [14] Lee S., Obata A., Kasuga T., Ion-release from SrO-CaO-TiO2-P2O5 Glasses in Tris Buffer Solution, J. Ceram. Soc. Jpn. 2009,117, 935–938
• [15] Gentleman E., Fredholm Y.C., Jell G., Lotfibakhshaiesh N.,O’Donnell M.D., Hill R.G., Stevens M.M., The Effects ofStrontium-Substituted Bioactive Glasses on Osteoblasts andOsteoclasts in vitro, Biomaterials 2010, 31, 3949–3956[Crossref][WoS]
• [16] Mandlule A., Döhler F., Wüllen L.van, Kasuga T., Brauer D.S.,Changes in Structure and Thermal Properties with PhosphateContent of Ternary Calcium Sodium Phosphate Glasses, J. Non-Cryst. Solids 2014, 392–393, 31–38
• [17] Lee S., Obata A., Kasuga T., Ion Releasing Abilities of PhosphateInvert Glasses Containing MgO, CaO or SrO in Tris Buffer Solution,Bioceram. Dev. Appl. 2010, 1, DOI: 10.4303/bda/D110148[Crossref]
• [18] Morikawa H., Lee S., Kasuga T., Brauer D.S., Effects of MagnesiumforCalciumSubstitution in P2O5-CaO-TiO2 Glasses, J. Non-Cryst. Solids 2013, 380, 53–59
• [19] Walter G., Vogel J., Hoppe U., Hartmann P., The Structure ofCaO–Na2O–MgO–P2O5 Invert Glass, J. Non-Cryst. Solids 2001,296, 212–223
• [20] Ouchetto M., Elouadi B., Parke S., Study of Lanthanide ZincPhosphate Glasses by Differential Thermal Analysis, Phys.Chem. Glasses 1991, 32, 22–28
• [21] Karakassides M.A., Saranti A., Koutselas I., Preparation andStructural Study of Binary Phosphate Glasseswith High Calciumand/orMagnesiumContent, J. Non-Cryst. Solids 2004, 347, 69–79
• [22] Sakka S., Miyaji F., Fukumi F., Structure of Binary K2O-TiO2 andCs2O-TiO2 Glasses, J. Non-Cryst. Solids 1989, 112, 64–68[Crossref]
• [23] Abou Neel E.A., Pickup D.M., Valappil S.P., Newport R.J.,Knowles J.C., Bioactive Functional Materials: A Perspective onPhosphate-based Glasses, J. Mater. Chem. 2009, 19, 690–701[Crossref][WoS]
• [24] Brauer D.S., Rüssel C., Kraft J., Solubility of Glasses in the SystemP2O5-CaO-MgO-Na2O-TiO2: Experimental and Modeling UsingArtificial Neural Networks, J. Non-Cryst. Solids 2007, 353,263–270[WoS]
• [25] Döhler F., Mandlule A., Wüllen L.van, Friedrich M., Brauer D.S.,31P NMR Characterisation of Phosphate Fragments During Dissolutionof CalciumSodiumPhosphate Glasses, J.Mater. Chem.B 2014, in press, DOI: 10.1039/c4tb01757a[Crossref]
• [26] Fredholm Y.C., Karpukhina N., LawR.V., Hill R.G., StrontiumContainingBioactive Glasses: Glass Structure and Physical Properties,J. Non-Cryst. Solids 2010, 356, 2546–2551[WoS]
• [27] Fredholm Y.C., Karpukhina N., Brauer D.S., Jones J.R., Law R.V.,Hill R.G., Influence of Strontium for Calcium Substitution inBioactive Glasses on Degradation, Ion Release and Apatite Formation,J. R. Soc. Interface 2012, 9, 880–889[Crossref][WoS]
• [28] Abou Neel E.A., Chrzanowski W., Pickup D.M., O’Dell L.A., MordanN.J., Newport R.J., Smith M.E., Knowles J.C., Structure andProperties of Strontium-Doped Phosphate-Based Glasses, J. R.Soc. Interface 2009, 6, 435–446[Crossref][WoS]
• [29] Dietzel A., Die Kationenfeldstärken und ihre Beziehungen zuEntglasungsvorgängen, zur Verbindungsbildung und zu denSchmelzpunkten von Silicaten, Ztschr. Elektrochem. 1942, 48,9–23
• [30] Watts S.J., Hill R.G., O’Donnell M.D., Law R.V., Influence of Magnesiaon the Structure and Properties of Bioactive Glasses, J.Non-Cryst. Solids 2010, 356, 517–524
• [31] Kishioka A., Haba M., Amagasa M., Glass Formation in MulticomponentPhosphate System Containing TiO2, Bull. Chem.Soc. Japan. 1974, 47, 2493–2496
• [32] Brauer D.S., Karpukhina N., Law R.V., Hill R.G., Effect of TiO2 Additionon Structure, Solubility and Crystallisation of Phosphate Invert Glasses for Biomedical Applications, J.Non-Cryst. Solids2010, 356, 2626–2633[WoS]
• [33] Tylkowski M., Brauer D.S., Mixed Alkali Effects in Bioglassr45S5, J.Non-Cryst. Solids 2013, 376, 175–181
• [34] Neel E.A., Ahmed I., Knowles J.C., Investigation of the Mixed AlkaliEffect in a Range of Phosphate Glasses, Key Eng. Mater.2007, 330–332, 161–164
• [35] Day D.E., Mixed Alkali Glasses - Their Properties and Uses,J.Non-Cryst. Solids 1976, 21, 343–372[Crossref]
• [36] Swenson J., Adams S., Mixed Alkali Effect in Glasses, Phys. Rev.Lett. 2003, 90, 155507-1-4.
• [37] Walter G., Vogel J., Hoppe U., Hartmann P., Structural Study ofMagnesium Polyphosphate Glasses, J. Non-Cryst. Solids 2003,320, 210–222
• [38] Walter G., Hoppe U., Kranold R., Stachel D., Structural Characterisationof Magnesium Phosphate Glasses by X-ray Diffraction,Phys. Chem. Glasses 1994, 35, 245–252
• [39] Barbara A., Delannoy P., Denis B.G., Marie P.J., Normal MatrixMineralization Induced By Strontium Ranelate in MC3T3-E1 OsteogenicCells, Metabolism 2004, 53, 532–537

Identyfikatory

DOI

10.1515/bglass-2015-0015